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BIO254:Silent: Difference between revisions
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Figure 3. AMPARs are inserted during LTP in hippocampal neurons in culture. Surface-expressed AMPARs on a living cultured hippocampal neuron detected using antibodies | |||
Figure 3. AMPARs are inserted during LTP in hippocampal neurons in culture. Surface-expressed AMPARs on a living cultured hippocampal neuron detected using antibodies before (top, orange) and after (middle, purple) induction of NMDAR-dependent LTP in culture. Colocalization is shown in the bottom panel. (Isaac, 2003) | |||
After the early phase of LTP (E-LTP) in which these pre- and post-synaptic changes occur, the late phase (L-LTP) can lead to the formation of new synapses. | After the early phase of LTP (E-LTP) in which these pre- and post-synaptic changes occur, the late phase (L-LTP) can lead to the formation of new synapses. | ||
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Groc, L, Gustafsson, B, and Hanse, E. (2006) AMPA signalling in nascent glutamatergic synapses: there and not there! Trends Neurosci: 29, 132-139. | Groc, L, Gustafsson, B, and Hanse, E. (2006) AMPA signalling in nascent glutamatergic synapses: there and not there! Trends Neurosci: 29, 132-139. | ||
Isaac, JTR. (2003) Postsynaptic silent synapses: evidence and mechanisms. Neuropharmacology: 45: 450-460. | |||
Shen, W, Wu, B, Zhang, Z, et al. (2006). Neuron: 50, 401–414. | Shen, W, Wu, B, Zhang, Z, et al. (2006). Neuron: 50, 401–414. | ||
