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BIO254:Silent: Difference between revisions
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It was found that CA3-CA1 LTP requires both NMDAR and Ca<sup>2+</sup>, and involves depolarization of the postsynaptic cell, activation of NMDA receptors in that cell, the resulting influx of Ca<sup>2+</sup>, and the activation of secondary messengers by Ca<sup>2+</sup>. | It was found that CA3-CA1 LTP requires both NMDAR and Ca<sup>2+</sup>, and involves depolarization of the postsynaptic cell, activation of NMDA receptors in that cell, the resulting influx of Ca<sup>2+</sup>, and the activation of secondary messengers by Ca<sup>2+</sup>. | ||
The specific expression mechanisms of CA3-CA1 LTP are highly controversial. However, we do know that the expression of LTP is likely to involve both pre- and postsynaptic mechanisms, and that the probability of presynaptic neurotransmitter release is increased after LTP induction. At the postsynaptic cell, AMPA receptors are inserted into the cell membrane, which increases the conductance of the AMPA channel and thereby converts '''silent synapses''' into functional ones. | The specific expression mechanisms of CA3-CA1 LTP are highly controversial. However, we do know that the expression of LTP is likely to involve both pre- and postsynaptic mechanisms, and that the probability of presynaptic neurotransmitter release is increased after LTP induction. At the postsynaptic cell, AMPA receptors are inserted into the cell membrane, which increases the conductance of the AMPA channel and thereby converts '''silent synapses''' into functional ones (Figure 3). | ||
After the early phase of LTP (E-LTP) in which these pre- and post-synaptic changes occur, the late phase (L-LTP) can lead to the formation of new synapses. | After the early phase of LTP (E-LTP) in which these pre- and post-synaptic changes occur, the late phase (L-LTP) can lead to the formation of new synapses. | ||
