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BIO254:Silent: Difference between revisions
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[[Image:unsilencing.jpg]] | [[Image:unsilencing.jpg]] | ||
Figure 1. Two models for maturation of AMPA receptor signalling. (a) Glutamate synapses are born without AMPA receptors and are AMPA-silent. They acquire AMPA receptors later, when exposed to the appropriate correlated presynaptic and postsynaptic activity, and they then becomes mature with respect to AMPA signalling. (b) Alternatively, glutamate synapses are born with AMPA receptors but can easily switch between AMPA-signalling (AMPA-labile) and AMPA-silent states. The presence or absence of AMPA receptor signalling depends on the synaptic activation history. Correlated presynaptic and postsynaptic activity translates the nascent synapse from this switching behaviour and the synapse becomes mature with respect to AMPA signalling. | |||
(Groc et al., 2006) | |||
The abundance of NMDA-receptor-only synapses peaks soon after post-natal development and decreases in adults. Hence, silent synapses appear not to be a separate class of excitatory synapses that are deficient in AMPA receptors, but are seen developmentally at an early stage of glutamatergic synapse maturation. | The abundance of NMDA-receptor-only synapses peaks soon after post-natal development and decreases in adults. Hence, silent synapses appear not to be a separate class of excitatory synapses that are deficient in AMPA receptors, but are seen developmentally at an early stage of glutamatergic synapse maturation. | ||
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<div style="margin-left: 60px;">[[Image:iGluR_phases.png]]</div> | <div style="margin-left: 60px;">[[Image:iGluR_phases.png]]</div> | ||
Figure 2 | |||
==NMDA receptors (NMDAR)== | ==NMDA receptors (NMDAR)== | ||
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Gomperts, SN, Carroll, R, Malenka, RC, et al. (2000) Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses. J Neurosci: 20, 2229-37. | Gomperts, SN, Carroll, R, Malenka, RC, et al. (2000) Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses. J Neurosci: 20, 2229-37. | ||
Groc, L, Gustafsson, B, and Hanse, E. (2006) AMPA signalling in nascent glutamatergic synapses: there and not there! Trends Neurosci: 29, 132-139. | |||
Shen, W, Wu, B, Zhang, Z, et al. (2006). Neuron: 50, 401–414. | Shen, W, Wu, B, Zhang, Z, et al. (2006). Neuron: 50, 401–414. | ||
