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BIO254:Silent: Difference between revisions
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→NMDA receptors (NMDAR)
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Also unlike AMPA receptors, open NMDA receptors permit the influx of Ca<sup>2+</sup>, which plays a role in LTP (see below). | Also unlike AMPA receptors, open NMDA receptors permit the influx of Ca<sup>2+</sup>, which plays a role in LTP (see below). | ||
The inactivity of an NMDA-only synapse when the postsynaptic cell is polarized below -40 mV gives the silent synapse its name. | The inactivity of an NMDA-only synapse when the postsynaptic cell is polarized below -40 mV gives the '''silent synapse''' its name. | ||
NMDA receptors are actively inhibited by APV (R-2-amino-5-phosphonopentanoate), which can thereby regulate silent synapse activity. | NMDA receptors are actively inhibited by APV (R-2-amino-5-phosphonopentanoate), which can thereby regulate '''silent synapse''' activity. | ||
==Long-term potentiation== | ==Long-term potentiation== | ||
