Jordan T. Detamore Week 11
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Purpose
The purpose of this week was to receive feedback on our HIV project and finalize our powerpoints.
Methods/Results
- We presented our rough draft of our powerpoint
- We received complements and feedback
- We finished our background slides displaying background on HIV, dS/dN, and different amino acids
- We changed our titles to be more concise
- We finished outlining the different changes in amino acids and visualized them on the 3D structure
- Some slides were rearranged and details were added for clarification
Data/Files
HIV 1 Structure Presentation: Media:HIV_Structure_Project_Zach_And_Jordan.pdf
Scientific Conclusion
We were able to edit and finish our powerpoint. We found that there was no clear correlation between dS/dN ratio and variance in amino acids. We also found that our 6 nonconsensual sites were from the V3 loop and another area on the outside of the gp120 protein. We stated that these mutations could affect the function of the protein as these areas interact with cells.
Acknowledgments
- I worked with my partner Zach Goldstein both in class and on Monday night on our powerpoint project.
- I received instruction from Dr. Dahlquist's in class as well
- While I worked with the people noted above, this individual journal entry was completed by me and not copied from another source.
Jordan T. Detamore 23:42, 14 November 2016 (EST):
References
- Andrianov, A. M., & Anishchenko, I. V. (2009). Computational model of the HIV-1 subtype A V3 loop: Study on the conformational mobility for structure-based anti-AIDS drug design. Journal of Biomolecular Structure and Dynamics, 27(2), 179-193. DOI: 10.1080/07391102.2009.10507308
- Kwong, P. D., Wyatt, R., Robinson, J., Sweet, R. W., Sodroski, J., & Hendrickson, W. A. (1998). Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature, 393(6686), 648-659. DOI: 10.1038/31405
- Biology Workbench
- Markham, R.B., Wang, W.C., Weisstein, A.E., Wang, Z., Munoz, A., Templeton, A., Margolick, J., Vlahov, D., Quinn, T., Farzadegan, H., & Yu, X.F. (1998). Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline. Proc Natl Acad Sci U S A. 95, 12568-12573. doi: 10.1073/pnas.95.21.12568
- BIOL368/F16:Week 11
Useful links
LMU Seaver College of Science and Engineering
