Jacobs

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Welcome to the Cell and Molecular Biomechanics Lab! CMBL is part of the Department of Biomedical Engineering at Columbia University! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation. Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading. This work has applications in developing new therapies to age-related bone loss and osteoporosis. We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice. Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium. GroupPhoto2010.jpg


News

  • 1/8/2011 CMBL Graduate Students Kristen Lee and Matthew Downs awarded travel grants and Postdoctoral Fellow Julia Chen awarded Best Podium at the 29th meeting of the SPRBM

Kristen Lee presented a paper entitled "TRPV4 is required for mechanotransduction in MC3T3 osteoblasts". Matthew Downs presented a paper entitled "Modeling and analysis of primary cilia under fluid flow". Julia Chen presented a paper entitled "The effect of oscillatory fluid flow on the osteogenic differentiation of human bone marrow stromal cells" on behalf of David Hoey. Abstracts for these papers are available on the SPRBM website (http://www.sprbm.org/assets/bmessprbm2011programbook.pdf)

  • 1/16/2010 CMBL Postdoctoral Fellow David Hoey awarded Best Presentation at the 28th meeting of the SPRBM

Postdoctoral fellow David Hoey was awarded best presentation in the Postdoctoral Category at the 28th meeting of the Society of Physical Regulation in Biology and Medicine. His paper was entitled “Determining the mechanisms of primary cilia bending in response to fluid shear stress”. This paper along with fellow CMBL member, graduate student Jennifer Blundo’s paper are available on the SPRBM website (http://www.pitt.edu/~sprbm/index.html)

  • 9/1/2009 CMBL Postdoc David Hoey awarded IRCSET-Marie Curie International Mobility Fellowship in Science, Engineering and Technology

The objective of the IRCSET-Marie Curie INSPIRE co-funded Scheme is to encourage Ireland-based researchers to avail of a structured period of overseas mobility with associated career development actions, followed by a corresponding return period in Ireland. David will spend two years here in Columbia University after which he will return to Prof. O’Brien's lab in the Royal College of Surgeons in Ireland (http://www.ircset.ie/Default.aspx?tabid=240)

  • 9/1/2009 The CMBL receives New York State Stem Cell Grant

The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load. The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board (NYSTEM). You can look at the lay abstract of the project here.

Recent updates to the lab wiki

25 September 2017

     17:38  User:Oww Bot‎ (diff | hist) . . (-956). . Yar (talk | contribs) (it me)

     17:36 

(User rights log). .

[Yar‎ (13×)]

     

17:36

. . Yar (talk | contribs) changed group membership for Oww Bot from bot and administrator to bot ‎

     

17:33

. . Yar (talk | contribs) changed group membership for Yeem from administrator to (none) ‎

     

17:33

. . Yar (talk | contribs) changed group membership for Ricardo Vidal from administrator to (none) ‎

     

17:33

. . Yar (talk | contribs) changed group membership for Reshma P. Shetty from bureaucrat and administrator to (none) ‎

     

17:32

. . Yar (talk | contribs) changed group membership for Rehears from bureaucrat and administrator to (none) ‎

     

17:31

. . Yar (talk | contribs) changed group membership for Lorrie LeJeune from bureaucrat and administrator to (none) ‎

     

17:31

. . Yar (talk | contribs) changed group membership for Jeff Brock from bureaucrat, dropboxuser and administrator to dropboxuser ‎

     

17:31

. . Yar (talk | contribs) changed group membership for Jason R. Kelly from bureaucrat and administrator to (none) ‎

     

17:31

. . Yar (talk | contribs) changed group membership for Ilya from bureaucrat, developer and administrator to developer ‎

     

17:30

. . Yar (talk | contribs) changed group membership for Bill Flanagan from bureaucrat and administrator to (none) ‎

     

17:30

. . Yar (talk | contribs) changed group membership for Barry Canton from bureaucrat and administrator to (none) ‎

     

17:29

. . Yar (talk | contribs) changed group membership for Austin J. Che from bureaucrat and administrator to (none) ‎

     

17:29

. . Yar (talk | contribs) changed group membership for Administrator from bureaucrat, developer and administrator to developer ‎

     17:35  User:Yar‎ (diff | hist) . . (+26). . Yar (talk | contribs) (my name)

     17:34 

(Move log). .

[Yar‎ (5×)]

     

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. . Yar (talk | contribs) moved page User talk:Yardena Cohen to User talk:Yar(Automatically moved page while renaming the user "Yardena Cohen" to "Yar")

     

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. . Yar (talk | contribs) moved page User:Yardena Cohen/Notebook/attempt/Entry Base to User:Yar/Notebook/attempt/Entry Base(Automatically moved page while renaming the user "Yardena Cohen" to "Yar")

     

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. . Yar (talk | contribs) moved page User:Yardena Cohen/Notebook/attempt to User:Yar/Notebook/attempt(Automatically moved page while renaming the user "Yardena Cohen" to "Yar")

     

17:34

. . Yar (talk | contribs) moved page User:Yardena Cohen/Notebook to User:Yar/Notebook(Automatically moved page while renaming the user "Yardena Cohen" to "Yar")

     

17:34

. . Yar (talk | contribs) moved page User:Yardena Cohen to User:Yar(Automatically moved page while renaming the user "Yardena Cohen" to "Yar")

     17:34 (User rename log) . . Yar (talk | contribs) renamed user Yardena Cohen (108 edits) to Yar(shorter)
     17:28  OpenWetWare:Bureaucrats‎ (diff | hist) . . (-58). . Yar (talk | contribs) (it me)
     17:28  OpenWetWare:Administrators‎ (diff | hist) . . (-187). . Yar (talk | contribs) (it me)

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User:Yardena Cohen‎‎ (3 changes | history) . . (+501). . [Yar‎ (3×)]

     

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(cur | prev) . . (+84). . Yar (talk | contribs) (link to 1.13.2 announcement from 2008...)

     

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(cur | prev) . . (+4). . Yar (talk | contribs) (contact link)

     

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(cur | prev) . . (+413). . Yar (talk | contribs) (allow myself to introduce myself)

     17:17  OpenWetWare:Mailing lists‎ (diff | hist) . . (-2,426). . Yar (talk | contribs) (update)
     17:15  CONJ606:Schedule‎ (diff | hist) . . (0). . Maureen E. Hoatlin (talk | contribs) (Week-by-Week Schedule Summary)

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PrivateWikis‎‎ (2 changes | history) . . (-8). . [Yar‎ (2×)]

     

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(cur | prev) . . (+3). . Yar (talk | contribs) (23)

     

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(cur | prev) . . (-11). . Yar (talk | contribs) (new contact page)

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New server‎‎ (5 changes | history) . . (+718). . [Yar‎ (5×)]

     

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(cur | prev) . . (+26). . Yar (talk | contribs) (private wikis link)

     

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(cur | prev) . . (+157). . Yar (talk | contribs) (check spam folder)

     

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(cur | prev) . . (-17). . Yar (talk | contribs) (idk when searches will work)

     

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(cur | prev) . . (+267). . Yar (talk | contribs) (rearrange, more info on passwords & emails)

     

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(cur | prev) . . (+285). . Yar (talk | contribs) (confirm emails)

     14:28  Main Page‎ (diff | hist) . . (+75). . Yar (talk | contribs) (confirm email)

     14:09 

(User creation log). .

[Yar‎ (2×)]

     

14:09

. . User account Abhilash (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

14:09

. . User account Jrajbhandary (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     12:14 

(Upload log). .

[Trevor S. Heaton‎; Anshul Krishnan‎ (2×); Vinh T. Le‎ (3×)]

     

12:14

. . Vinh T. Le (talk | contribs) uploaded File:ZOLA9252017 3.PNG

     

12:14

. . Vinh T. Le (talk | contribs) uploaded File:ZOLA9252017 2.PNG

     

12:13

. . Vinh T. Le (talk | contribs) uploaded File:ZOLA9252017 1.PNG

     

09:18

. . Trevor S. Heaton (talk | contribs) uploaded a new version of File:Graph 1.PNG

     

06:18

. . Anshul Krishnan (talk | contribs) uploaded File:BME100TempVTrials.png

     

06:10

. . Anshul Krishnan (talk | contribs) uploaded File:BME100L3Temp.png

24 September 2017

N    22:33  MediaWiki:Tagline‎ (diff | hist) . . (+16). . Yar (talk | contribs) (less parsing)
N    22:32  MediaWiki:Pagetitle-view-mainpage‎ (diff | hist) . . (+11). . Yar (talk | contribs) (less parsing)
N    22:32  MediaWiki:Opensearch-desc‎ (diff | hist) . . (+16). . Yar (talk | contribs) (english-only?)
N    21:21  MediaWiki:Pagetitle‎ (diff | hist) . . (+16). . Yar (talk | contribs) (idk if this will help or hurt)
N    21:18  MediaWiki:Aboutsite‎ (diff | hist) . . (+17). . Yar (talk | contribs) (one less thing to parse)