# Jacobs:NYSTEM abstract

Osteoporosis is a disease where loss of bone tissue leads to increased risk of fracture at loads that would not normally be traumatic. It is a major health risk for 44 million Americans, 68% of whom are women. One out of every two women and one out or every four men over the age of 50 are predicted to experience an osteoporotic fracture in their lifetimes. Hip fractures are particularly debilitating often leading to loss of independence, institutionalization, and mortality with up to 30% of patients dying in the first year post-fracture. In fact, more women die of osteoporosis than breast cancer. National direct expenditures are estimated to be $14 billion annually and are predicted to reach$240 billion by 2040.