Karenliu: Difference between revisions

← Older edit Newer edit →

Revision as of 10:09, 13 August 2013

The Liu Lab

Department of Craniofacial Biology

Kings College London

Welcome to the Liu lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.

The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.

Recent updates to the lab wiki

List of abbreviations:

N: This edit created a new page (also see list of new pages)
m: This is a minor edit
b: This edit was performed by a bot
(±123): The page size changed by this number of bytes

2 April 2026

			19:57		(Upload log) [Xinyu Liu; David Altman (8×)]
					19:57 David Altman talk contribs uploaded File:LabPicSpring2026.jpeg
					19:57 David Altman talk contribs uploaded File:OASposterSpring2026.jpeg
					19:56 David Altman talk contribs uploaded File:OAStalkSpring2026.jpeg
					19:42 David Altman talk contribs uploaded File:Soto WUbites Spring 2026.pdf
					19:42 David Altman talk contribs uploaded File:Shipp WUbites Spring 2026.pdf
					19:42 David Altman talk contribs uploaded File:Margerum WUbites Spring 2026.pdf
					19:42 David Altman talk contribs uploaded File:Bentley WUbites Spring 2026.pdf
					19:40 David Altman talk contribs uploaded File:Bashioum WUbites Spring 2026.pdf
					09:27 Xinyu Liu talk contribs uploaded File:Small2026.jpg

19:56

Altman:Pictures diffhist +354 David Altman talk contribs

19:50

Altman diffhist −54 David Altman talk contribs (→News)

			19:40		Altman:WUbites 2 changes history +992 [David Altman (2×)]
					19:40 (cur \| prev) +40 David Altman talk contribs (→WUbites)
					19:39 (cur \| prev) +952 David Altman talk contribs (→WUbites)

18:36

CHIP:Talks diffhist −19 Gabor Balazsi talk contribs

			09:28		Gao lab:Publications 2 changes history +549 [Xinyu Liu (2×)]
					09:28 (cur \| prev) +24 Xinyu Liu talk contribs (→Publications)
					09:26 (cur \| prev) +525 Xinyu Liu talk contribs (→Publications)

1 April 2026

			11:32		Hu 2 changes history +121 [Hugangqing (2×)]
					11:32 (cur \| prev) +2 Hugangqing talk contribs
					11:32 (cur \| prev) +119 Hugangqing talk contribs