Karenliu
| The Liu Lab | Department of Craniofacial Biology | Kings College London |
| Home | Research | Publications | Protocols & Etc. | Lab Members | Contact Us | Links |
Welcome to the Liu Lab!
We are interested in signal transduction in developmental biology.
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
<wikionly>
Recent updates to the lab wiki
List of abbreviations:
- N
- This edit created a new page (also see list of new pages)
- m
- This is a minor edit
- b
- This edit was performed by a bot
- (±123)
- The page size changed by this number of bytes
30 October 2025
27 October 2025
|
|
09:43 | Template:Navbar icons 4 changes history −6 [Yar (4×)] | |||
|
|
09:43 (cur | prev) −4 Yar talk contribs (shorter) | ||||
|
|
09:22 (cur | prev) −1 Yar talk contribs (tweak names) | ||||
|
|
09:21 (cur | prev) −225 Yar talk contribs (no more small text) | ||||
|
|
09:05 (cur | prev) +224 Yar talk contribs (new lab notebook icon) | ||||
|
|
09:42 | Template:Oww blurb 4 changes history −257 [Yar (4×)] | |||
|
|
09:42 (cur | prev) −27 Yar talk contribs (shorter) | ||||
|
|
09:41 (cur | prev) +12 Yar talk contribs (fix name) | ||||
|
|
09:39 (cur | prev) −149 Yar talk contribs (shorten blurb even more) | ||||
|
|
09:34 (cur | prev) −93 Yar talk contribs (update blurb) Tag: Manual revert | ||||
|
|
09:30 | Server Updates 5 changes history +396 [Yar (5×)] | |||
|
|
09:30 (cur | prev) 0 Yar talk contribs (include date too) | ||||
|
|
09:28 (cur | prev) +131 Yar talk contribs (welcome back) | ||||
|
|
09:14 (cur | prev) −1 Yar talk contribs (less whitespace) | ||||
|
|
09:14 (cur | prev) +29 Yar talk contribs (onlyinclude) | ||||
|
|
09:11 (cur | prev) +237 Yar talk contribs (update for today) | ||||
|
|
09:29 | Main Page 3 changes history −257 [Yar (3×)] | |||
|
|
09:29 (cur | prev) +71 Yar talk contribs (see all our previous server updates) | ||||
|
|
09:24 (cur | prev) 0 Yar talk contribs (fix capital) | ||||
|
|
09:19 (cur | prev) −328 Yar talk contribs (include server updates) | ||||
| N 09:24 | Server updates diffhist +28 Yar talk contribs (capitalize) | ||||
| 09:23 | Lab Notebooks diffhist −41 Yar talk contribs (redirect) | ||||
|
|
09:08 | (Move log) [Yar (2×)] | |||
|
|
09:08 Yar talk contribs moved page Talk:New server to Talk:Server Updates | ||||
|
|
09:08 Yar talk contribs moved page New server to Server Updates | ||||
| 09:04 | Upload log Yar talk contribs uploaded File:Notebook white.png (lab notebook icon to complement the 20-year-old icons for other stuff) | ||||
| 08:24 | Deletion log Yar talk contribs deleted page User:Worcesterflan (Automatically deleted page while merging users) | ||||
|
|
08:24 | (User merge log) [Yar (2×)] | |||
|
|
08:24 Yar talk contribs deleted the user account "Worcesterflan" (19409) | ||||
|
|
08:24 Yar talk contribs merged the user account "Worcesterflan" (19409) into DeletedUser (17767) | ||||
| 08:17 | User creation log User account 127.0.0.1 talk was created by Yar talk contribs and password was sent by email | ||||
24 October 2025
|
|
23:16 | (Move log) [Yar (2×)] | |||
|
|
23:16 Yar talk contribs moved page RawHTML:TomlinsonTwitter to TomlinsonTwitter | ||||
|
|
23:16 Yar talk contribs moved page RawHTML:Tomlinsoncal to Tomlinsoncal | ||||
| N 23:16 | RawHTML:TomlinsonTwitter diffhist +30 Yar talk contribs (Yar moved page RawHTML:TomlinsonTwitter to TomlinsonTwitter) | ||||
| N 23:16 | RawHTML:Tomlinsoncal diffhist +26 Yar talk contribs (Yar moved page RawHTML:Tomlinsoncal to Tomlinsoncal) | ||||
|
|
23:15 | Tomlinsoncal 2 changes history −130 [Yar (2×)] | |||
|
|
23:15 (cur | prev) −2 Yar talk contribs (just the link) | ||||
|
|
23:15 (cur | prev) −128 Yar talk contribs (no raw html) | ||||
| 23:14 | TomlinsonTwitter diffhist −138 Yar talk contribs (no raw html) | ||||
| 22:52 | MediaWiki:Sidebar diffhist +33 Yar talk contribs (new code path for specialpages) | ||||
<nonwikionly> This page was created using Open Wetware.</nonwikionly>
