Karenliu

The Liu Lab

Department of Craniofacial Biology

Kings College London

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Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.

The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.

Recent updates to the lab wiki

List of abbreviations:

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27 September 2020

			12:51		Owen R. Dailey Week 4‎‎ 5 changes history +35,223‎ [Owen R. Dailey‎ (5×)]
					12:51 (cur \| prev) -555‎ Owen R. Dailey talk contribs →‎Part 2: Creating a phylogenetic tree with Phylogeny.fr: Added more to part 2 methods/results
					12:31 (cur \| prev) +29,605‎ Owen R. Dailey talk contribs →‎Part 2: Creating a phylogenetic tree with Phylogeny.fr: Added a large portion of the methods/results for part 2
					11:37 (cur \| prev) +4,879‎ Owen R. Dailey talk contribs →‎Methods/Results: Added part 2 protocol to edit
					11:36 (cur \| prev) +75‎ Owen R. Dailey talk contribs →‎Part 1: GenBank: Added a link to week 4 assignment page
					11:34 (cur \| prev) +1,219‎ Owen R. Dailey talk contribs →‎Part 1: GenBank: Added the Part 1 Methods/Results

26 September 2020

			13:47		Nathan R Beshai Week 4‎‎ 4 changes history +1,237‎ [Nathan R. Beshai‎ (4×)]
					13:47 (cur \| prev) +1,074‎ Nathan R. Beshai talk contribs added what Genbank says about SARS coronavirus Urbani
					13:30 (cur \| prev) +90‎ Nathan R. Beshai talk contribs added sequence for chosen pdf
					13:13 (cur \| prev) 0‎ Nathan R. Beshai talk contribs changed formatting
					13:13 (cur \| prev) +73‎ Nathan R. Beshai talk contribs added rendered phylogenetic tree

			13:25		(Upload log)‎ [Michael S Beauchamp‎; Nathan R. Beshai‎ (2×)]
					13:25 Nathan R. Beshai talk contribs uploaded File:SARS coronavirus Urbani, complete genome.pdf ‎(added chosen sequence)
					13:11 Nathan R. Beshai talk contribs uploaded File:Nathan Week4Phylogenetictree.png ‎(added phylogenetic tree)
					11:30 Michael S Beauchamp talk contribs uploaded File:Metzger et al JNeurosci 2020 v2.pdf ‎

11:28

Beauchamp:Publications‎ diffhist +3‎ Michael S Beauchamp talk contribs

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Ernesto-Perez-Rueda:Publications‎ diffhist +74‎ Ernesto Perez-Rueda talk contribs

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Renhao Li Lab:Publications‎ diffhist +66‎ Renhao Li talk contribs →‎2020

m 05:43

Forster Lab‎ diffhist +9‎ Anthony C. Forster talk contribs

25 September 2020

16:51

Min-Ho Kim Lab:Publications‎ diffhist +204‎ Min-Ho Kim talk contribs

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Qin:Lab Members‎ diffhist +1‎ Yaning talk contribs →‎Hejian Xiong

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Qin:Research‎ diffhist -10‎ Yaning talk contribs →‎Point-of-care diagnosis for infectious diseases

			m 13:20		Griffin:Nested RT-PCR‎‎ 11 changes history +2,286‎ [Korey Griffin‎ (11×)]
			m		13:20 (cur \| prev) +153‎ Korey Griffin talk contribs →‎PCR Optimization
			m		13:17 (cur \| prev) +224‎ Korey Griffin talk contribs →‎DNA Contamination
			m		12:52 (cur \| prev) 0‎ Korey Griffin talk contribs →‎PCR Optimization
			m		12:52 (cur \| prev) +102‎ Korey Griffin talk contribs →‎PCR Optimization
			m		12:51 (cur \| prev) +655‎ Korey Griffin talk contribs →‎-/+ Reverse Transcriptase
			m		12:23 (cur \| prev) +149‎ Korey Griffin talk contribs →‎DNA Contamination
			m		12:06 (cur \| prev) 0‎ Korey Griffin talk contribs →‎DNA Contamination
			m		12:06 (cur \| prev) +68‎ Korey Griffin talk contribs →‎DNA Contamination
			m		12:03 (cur \| prev) +56‎ Korey Griffin talk contribs →‎DNA Contamination
			m		12:01 (cur \| prev) +33‎ Korey Griffin talk contribs →‎DNA Contamination
			m		12:00 (cur \| prev) +846‎ Korey Griffin talk contribs →‎PCR Optimization

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CAMRI:SeminarSeries‎ diffhist +63‎ Michael S Beauchamp talk contribs

24 September 2020

N 18:18

Ian R. Wright Week 4‎ diffhist +1,119‎ BallonaBuddy talk contribs starting references

			17:33		Yaniv Maddahi Journal Week 4‎‎ 6 changes history +28,212‎ [Yaniv Maddahi‎ (6×)]
					17:33 (cur \| prev) +9,015‎ Yaniv Maddahi talk contribs Added spaces and cluster sequence
					17:23 (cur \| prev) +57‎ Yaniv Maddahi talk contribs Added phylogenetic tree
					17:18 (cur \| prev) +12‎ Yaniv Maddahi talk contribs Added template header
					17:17 (cur \| prev) -1‎ Yaniv Maddahi talk contribs fixed a space for title
					17:17 (cur \| prev) +1‎ Yaniv Maddahi talk contribs Fixed a space in it
					17:16 (cur \| prev) +19,128‎ Yaniv Maddahi talk contribs Added all spike sequences

			17:32		Macie Duran Week 4‎‎ 2 changes history +29,518‎ [Macie Duran‎ (2×)]
					17:32 (cur \| prev) +3‎ Macie Duran talk contribs →‎Clustal Alignment of Spike Protein Sequences: fixed spacing errors in sequence alignment
					17:30 (cur \| prev) +29,515‎ Macie Duran talk contribs →‎Method & Results: added aligned sequences