Karenliu

From OpenWetWare
Jump to navigationJump to search
The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links


Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


banner


The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


<wikionly>

Recent updates to the lab wiki

List of abbreviations:
N
This edit created a new page (also see list of new pages)
m
This is a minor edit
b
This edit was performed by a bot
(±123)
The page size changed by this number of bytes

23 January 2021

     20:55  Gao lab:Research‎‎ 5 changes history +62 [Gaoweiping‎ (5×)]
     
20:55 (cur | prev) 0 Gaoweiping talk contribs →‎Biomaterials
     
20:54 (cur | prev) +3 Gaoweiping talk contribs →‎Protein Engineering
     
20:54 (cur | prev) +20 Gaoweiping talk contribs →‎Research Areas
     
19:05 (cur | prev) -17 Gaoweiping talk contribs →‎Protein Engineering
     
18:51 (cur | prev) +56 Gaoweiping talk contribs
     19:41  Gao lab:Members diffhist +75 Xinyu Liu talk contribs →‎Lab Members
     19:36  Template:Gao lab diffhist +6 Xinyu Liu talk contribs
     16:37  (User creation log) [Yar‎ (2×)]
     
16:37 User account Arotelab talk contribs was created by Yar talk contribs and password was sent by email ‎
     
16:37 User account H.Rafi talk contribs was created by Yar talk contribs and password was sent by email ‎

22 January 2021

     16:32  User:Jessica A. DaMota diffhist +346 Jessica A. DaMota talk contribs →‎COVID-19 Research Project: uploaded annotated bibliography
     16:28  TMPRSS2 Lab Notebook‎‎ 27 changes history +2,526 [Adinulos‎; Jessica A. DaMota‎ (13×); Erykah I Walton‎ (13×)]
     
16:28 (cur | prev) +80 Jessica A. DaMota talk contribs →‎Data and Files: uploaded Jessica's Annotated Bibliography
     
14:41 (cur | prev) +50 Jessica A. DaMota talk contribs →‎Structural Model of TMPRSS4: linked the HHPRED model
     
14:39 (cur | prev) +637 Jessica A. DaMota talk contribs →‎Structural Model of TMPRSS4: added FASTA sequence of TMPRSS4
     
14:35 (cur | prev) +178 Jessica A. DaMota talk contribs →‎TMPRSS4: uploaded image of TMPRSS4 model from HHPRED
     
14:03 (cur | prev) -10 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of rs2070788, rs383510, rs139010197
     
13:39 (cur | prev) +4 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of rs353163
     
13:34 (cur | prev) +2 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of rs977728
     
13:33 (cur | prev) +2 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
13:29 (cur | prev) +6 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
13:29 (cur | prev) +3 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of rs75603675 G8D
     
13:27 (cur | prev) -7 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
13:26 (cur | prev) +3 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of rs61735790
     
13:24 (cur | prev) +62 Adinulos talk contribs →‎Data and Files: added written report
     
13:21 (cur | prev) +21 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of | rs201679623
     
13:21 (cur | prev) +8 Erykah I Walton talk contribs rs75603675
     
13:15 (cur | prev) +3 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of rs61735793
     
13:15 (cur | prev) +121 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
13:08 (cur | prev) +17 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 predictions of rs775603675 and rs12329760
     
13:00 (cur | prev) +279 Jessica A. DaMota talk contribs →‎TMPRSS2 SNP Predictions: added PolyPhen-2 description
     
12:59 (cur | prev) +6 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
12:57 (cur | prev) +6 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
12:56 (cur | prev) +6 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
12:55 (cur | prev) +21 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
12:51 (cur | prev) 0 Erykah I Walton talk contribs →‎TMPRSS2 SNP Predictions
     
12:50 (cur | prev) +301 Erykah I Walton talk contribs SIFT description
     
12:42 (cur | prev) +699 Erykah I Walton talk contribs added SIFT and Polyphen table
     
12:40 (cur | prev) +28 Erykah I Walton talk contribs added TMPRSS2 SNP prediction section
     16:26  (Upload log) [Mking44‎; Adinulos‎ (2×); Jessica A. DaMota‎ (3×)]
     
16:26 Jessica A. DaMota talk contribs uploaded File:Annotated Bibliography JDamota.pdf(Annotated Bibliography of COVID-19 research focused on TMPRSS2 SNPs written by Jessica DaMota.)
     
16:24 Jessica A. DaMota talk contribs uploaded File:Annotated Bibliography.pdf(Annotated Bibliography of COVID-19 research focused on TMPRSS2 SNPs.)
     
14:32 Jessica A. DaMota talk contribs uploaded File:TMPRSS4 HHPRED.png(3D visual model of TMPRS44 generated using HHPred Software)
     
13:54 Mking44 talk contribs uploaded File:King Title&AnnotatedBibliography.pdf
     
12:34 Adinulos talk contribs uploaded File:Dinulos TMPRSS2Report.pdf(added tmprss2 report)
     
11:54 Adinulos talk contribs uploaded File:Dinulos AnnotatedBib.pdf(uploaded annotated bibliography)
     13:59  User:Mking44‎‎ 4 changes history +348 [Mking44‎ (4×)]
     
13:59 (cur | prev) +47 Mking44 talk contribs →‎Capstone: added link
     
13:24 (cur | prev) +144 Mking44 talk contribs →‎Madeleine King: added capstone heading and sections
     
13:21 (cur | prev) +69 Mking44 talk contribs →‎Research: corrected research
     
13:20 (cur | prev) +88 Mking44 talk contribs →‎Upper Division Courses: added course
N    13:28  User:Catherine Channell diffhist +34 Catherine Channell talk contribs Created page with "Catherine I. Channell Lab Notebook"
     12:39  User:Adinulos diffhist +62 Adinulos talk contribs →‎TMPRSS2 Written Report: added report
     12:04 User creation log User account Catherine Channell talk contribs was created by Yar talk contribs and password was sent by email ‎
</wikionly>

<nonwikionly> This page was created using Open Wetware.</nonwikionly>