Karenliu

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The Liu Lab Department of Craniofacial Biology Kings College London
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Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


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27 September 2020

     12:51  Owen R. Dailey Week 4‎‎ 5 changes history +35,223 [Owen R. Dailey‎ (5×)]
     
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12:31 (cur | prev) +29,605 Owen R. Dailey talk contribs →‎Part 2: Creating a phylogenetic tree with Phylogeny.fr: Added a large portion of the methods/results for part 2
     
11:37 (cur | prev) +4,879 Owen R. Dailey talk contribs →‎Methods/Results: Added part 2 protocol to edit
     
11:36 (cur | prev) +75 Owen R. Dailey talk contribs →‎Part 1: GenBank: Added a link to week 4 assignment page
     
11:34 (cur | prev) +1,219 Owen R. Dailey talk contribs →‎Part 1: GenBank: Added the Part 1 Methods/Results

26 September 2020

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13:25 Nathan R. Beshai talk contribs uploaded File:SARS coronavirus Urbani, complete genome.pdf(added chosen sequence)
     
13:11 Nathan R. Beshai talk contribs uploaded File:Nathan Week4Phylogenetictree.png(added phylogenetic tree)
     
11:30 Michael S Beauchamp talk contribs uploaded File:Metzger et al JNeurosci 2020 v2.pdf
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25 September 2020

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24 September 2020

N    18:18  Ian R. Wright Week 4 diffhist +1,119 BallonaBuddy talk contribs starting references
     17:33  Yaniv Maddahi Journal Week 4‎‎ 6 changes history +28,212 [Yaniv Maddahi‎ (6×)]
     
17:33 (cur | prev) +9,015 Yaniv Maddahi talk contribs Added spaces and cluster sequence
     
17:23 (cur | prev) +57 Yaniv Maddahi talk contribs Added phylogenetic tree
     
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17:16 (cur | prev) +19,128 Yaniv Maddahi talk contribs Added all spike sequences
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17:32 (cur | prev) +3 Macie Duran talk contribs →‎Clustal Alignment of Spike Protein Sequences: fixed spacing errors in sequence alignment
     
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     17:28  Nathan R Beshai Week 4 diffhist +29,552 Nathan R. Beshai talk contribs added sequences and spaces
     17:25  (Upload log) [Yaniv Maddahi‎; Jcorrey‎]
     
17:25 Jcorrey talk contribs uploaded File:CorreyPhyloTree.JPG
     
17:23 Yaniv Maddahi talk contribs uploaded File:Maddahi phylo tree.png
     17:25  Owen R. Dailey Week 4 diffhist -1,938 Owen R. Dailey talk contribs →‎Part 1: GenBank: Added more materials/results
     17:21  BIOL368/S19 Week 4 diffhist +15 Falghane talk contribs space sequance 1
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     17:11  BIOL368/F20:Week 4 diffhist -1 Macie Duran talk contribs →‎Data & Tools
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