Karenliu

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The Liu Lab Department of Craniofacial Biology Kings College London
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Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


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Recent updates to the lab wiki

15 July 2018

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Chenlab:Recruiting‎‎ (8 changes | history) . . (-150). . [Kaifu Chen‎ (8×)]

     

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     00:45  Park Lab :Lab Members‎ (diff | hist) . . (+229). . Jeewoong Lee (talk | contribs) (Undergraduate Student)

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Park Lab :Publications‎‎ (2 changes | history) . . (+308). . [Jeewoong Lee‎ (2×)]

     

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13 July 2018

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(User creation log). .

[Yar‎ (2×)]

     

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. . User account Luca.ro20 (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

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. . User account Cecilyryan (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     17:13  BioMicroCenter:BioinfoClasses‎ (diff | hist) . . (-59). . Duanduan Ma (talk | contribs)

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Barnes:Contact‎‎ (2 changes | history) . . (+4). . [Jack R‎ (2×)]

     

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(cur | prev) . . (+2). . Jack R (talk | contribs) (Mail)

     

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(Upload log). .

[Jack R‎ (6×)]

     

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. . Jack R (talk | contribs) uploaded File:Glycerol Stocks.pdf(Protocol for setting up glycerol stocks. Used for long-term storage of bacterial strains.)

     

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. . Jack R (talk | contribs) uploaded File:Syphonstat.pdf(Operating instructions for the syphonstat.)

     

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. . Jack R (talk | contribs) uploaded File:Electrocompetent Cells.pdf(Protocol for preparing electrocompetent cells, using a glycerol-manitol step.)

     

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. . Jack R (talk | contribs) uploaded File:Electroporation.pdf(Protocol for electroporation transformation of cells.)

     

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. . Jack R (talk | contribs) uploaded File:Flow-SOP.pdf(Instructions for starting up and running flow cytometer.)

     

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. . Jack R (talk | contribs) uploaded File:Gel electrophoresis.pdf(Protocol for carrying out an agarose gel electrophoresis.)

     06:18  Lee:Publications‎ (diff | hist) . . (+213). . Wooin Lee (talk | contribs) (2018)
     01:34  Barnes:Lab Members‎ (diff | hist) . . (+6). . Jack R (talk | contribs) (Alumni)

12 July 2018

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(Upload log). .

[ChanEngr‎ (2×); Ryan E. Tomlinson‎ (3×)]

     

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. . ChanEngr (talk | contribs) uploaded File:YANGYX20182.jpg

     

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. . Ryan E. Tomlinson (talk | contribs) uploaded a new version of File:Sonya.jpg

     

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. . Ryan E. Tomlinson (talk | contribs) uploaded File:Sonya.jpg

     

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. . Ryan E. Tomlinson (talk | contribs) uploaded a new version of File:Nick.jpg

     16:23 (User creation log) . . User account Alexagarcia (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎
     14:16  Beauchamp:ROIanalysis‎ (diff | hist) . . (+298). . Meghanr (talk | contribs) (What if the FreeSurfer parcellation doesn't work)

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Beauchamp:Unwarping‎‎ (2 changes | history) . . (+6,477). . [Meghanr‎ (2×)]

     

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(cur | prev) . . (+2,172). . Meghanr (talk | contribs) (Two EPIs with different phase encode directions)

     

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Beauchamp:RestingState‎‎ (2 changes | history) . . (+766). . [Meghanr‎ (2×)]

     

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Tomlinson:Lab Members‎‎ (2 changes | history) . . (-28). . [Ryan E. Tomlinson‎ (2×)]

     

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