Gao lab:Publications

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Biomaterials & Drug Delivery Lab


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Publications

Zhaoying Yang, Qiongqiong Yao, Like Gong, Fan Zhang, Jiawei Sun, Yuanzi Sun, Weiping Gao. "A Superlong-acting Growth Hormone-polypeptide Fusion for Growth Hormone Deficiency Treatment"Advanced Healthcare Materials, 2023, 10.1002/adhm.202302507



Wenchao Huang, Longshuai Zhang, Jiawei Sun, Yuanzi Sun, Like Gong, Sisi Ge, Xunbin Wei, Weiping Gao. "Spatiotemporally-Programmed Dual-Acid-Sensitive Nanoworms of Albumin-Poly(tertiary amine)-Doxorubicin Conjugates for Enhanced Cancer Chemotherapy"Advanced Healthcare Materials, 2023, 10.1002/adhm.202301890



刘欣宇, 高卫平. "蛋白质定点原位可控聚合方法(SICP)的发展与应用"高分子学报, 2023, 10.11777/j.issn1000-3304.2023.23088



Sanke Zhang, Yuanzi Sun, Longshuai Zhang, Fan Zhang, Weiping Gao. "Thermoresponsive Polypeptide Fused L-Asparaginase with Mitigated Immunogenicity and Enhanced Efficacy in Treating Hematologic Malignancies"Advanced Science 2023



Jiawei Sun, Jianwen Guo, Longshuai Zhang, Like Gong, Yuanzi Sun, Xuliang Deng, Weiping Gao. "Active-targeting long-acting protein-glycopolymer conjugates for selective cancer therapy"Journal of Controlled Release 2023, 356, 175-184


Fei Duan, Wei Jin, Tong Zhang, Yuanzi Sun, Xuliang Deng, Weiping Gao. "Thermo-pH-Sensitive Polymer Conjugated Glucose Oxidase for Tumour-Selective Starvation-Oxidation-Immune Therapy" Adv. Mater. 2023, XXXX, XXX, XXX-XXX


Longshuai Zhang, Jiawei Sun, Wenchao Huang, Sanke Zhang, Xuliang Deng, Weiping Gao. "Hypoxia-Triggered Bioreduction of Poly(N-oxide)–Drug Conjugates Enhances Tumor Penetration and Antitumor Efficacy"J. Am. Chem. Soc. 2023, XXXX, XXX, XXX-XXX


Xiang Zhang, Fei Duan, Fan Zhang, Xuliang Deng, Weiping Gao. "Thermosensitive Polymer Conjugated Prodrug-Activating Enzyme with Enhanced Tumor Retention and Antitumor Efficacy"Biomacromolecules 2022, 23, 11, 4834–4840


Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang, Xuliang Deng, Cyrille Boyer, Weiping Gao. "N-Terminal Lysozyme Conjugation to a Cationic Polymer Enhances Antimicrobial Activity and Overcomes Antimicrobial Resistance"Nano Lett. 2022, XXXX, XXX, XXX-XXX


Like Gong, ZhaoyingYang, Fan Zhang, Weiping Gao. "Cytokine conjugates to elastin-like polypeptides"Advanced Drug Delivery Reviews 2022, 190, 114541


Fei Duan, Wei Jin, Tong Zhang, Fan Zhang, Like Gong, Xinyu Liu, Xuliang Deng, Weiping Gao. "Self-Activated Cascade Biocatalysis of Glucose Oxidase–Polycation–Iron Nanoconjugates Augments Cancer Immunotherapy"ACS Appl. Mater. Interfaces 2022, 14, 29, 32823–32835


WenHao Wu, Jianwen Guo, Longshuai Zhang, WenBin Zhang, Weiping Gao. "Peptide/protein-based macrocycles: from biological synthesis to biomedical applications"RSC Chem. Biol. 2022, 3, 815-829


Zhaoying Yang, Fan Zhang, Jianwen Guo, Weiping Gao. "Biosynthesis of Elastin-Like Polypeptides and their applications in drug delivery"Synthetic Biology Journal,1-19


Jiawei Sun, Xinyu Liu, Jianwen Guo, Wenguo Zhao, Weiping Gao. "Pyridine-2,6-dicarboxaldehyde-Enabled N-Terminal In Situ Growth of Polymer–Interferon α Conjugates with Significantly Improved Pharmacokinetics and In Vivo Bioactivity"ACS Appl. Mater. Interfaces 2021, 13, 88


Ping Liang, Guihuai Wang, Xinyu Liu, Zhuoran Wang, Jing Wang, Weiping Gao. "Spatiotemporal combination of thermosensitive polypeptide fused interferon and temozolomide for post-surgical glioblastoma immunochemotherapy"Biomaterials 2021, 264, 120447


Zhuoran Wang, Jianwen Guo, Xinyu Liu, Jiawei Sun, Weiping Gao. "Temperature-triggered micellization of interferon alpha-diblock copolypeptide conjugate with enhanced stability and pharmacology"J. Controlled Release 2020, 328, 444


Xinyu Liu, Weiping Gao. "Precision Conjugation: An Emerging Tool for Generating Protein‐Polymer Conjugates"Angew. Chem. Int. Ed. 2021, 60, 11024–11035



Jianwen Guo, Jiawei Sun, Xinyu Liu, Zhuoran Wang, Weiping Gao. "Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology"Biomaterials 2020, 250, 120073



Chi-Wei Chiang, Xinyu Liu, Jiawei Sun, Jianwen Guo, Lei Tao, Weiping Gao. "Polymerization-induced co-assembly of enzyme-polymer conjugates into co-micelles with tunable and enhanced cascade activity"Nano Lett. 2019, 20, 1383-1387



Rongzan Lin, Xinghui Yan, Hanjun Hao, Weiping Gao, Ran Liu. "Introducing Temperature-Controlled Phase Transition Elastin-like Polypeptides to Transient Electronics: Realization of Proactive Biotriggered Electronics with Local Transience"ACS Appl. Mater. Interfaces 2019, 11, 50, 46490



Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao. "Thermoresponsive and Protease-Cleavable Interferon-Polypeptide Conjugates with Spatiotemporally Programmed Two-Step Release Kinetics for Tumor Therapy"Adv. Sci., 2019, 1900586



Hanjun Hao, Mengmeng Sun, Pengyong Li, Jiawei Sun, Xinyu Liu, Weiping Gao. "In Situ Growth of a Cationic Polymer from the N-Terminus of Glucose Oxidase To Regulate H2O2 Generation for Cancer Starvation and H2O2 Therapy"ACS Appl. Mater. Interfaces, 2019, 11, 9756-9762



Xuyang Sun, Mengmeng Sun, Miaomiao Liu, Bo Yuan, Weiping Gao, Wei Rao, Jing Liu. "Shape tunable gallium nanorods mediated tumor enhanced ablation through near-infrared photothermal therapy"Nanoscale, 2019, 11, 2655


Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao. "One-Month Zero-Order Sustained Release and Tumor Eradication after a Single Subcutaneous Injection of Interferon Alpha Fused with a Body-Temperature-Responsive Polypeptide"Biomater. Sci., 2019, 7, 104-112



Pengyong Li, Mengmeng Sun, Zhikun Xu, Xinyu Liu, Wenguo Zhao, and Weiping Gao. "Site-Selective in Situ Growth-Induced Self-Assembly of Protein–Polymer Conjugates into pH-Responsive Micelles for Tumor Microenvironment Triggered Fluorescence Imaging"Biomacromolecules, 2018, 19, 4472–4479



Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, and Weiping Gao. "Polymerization Induced Self-Assembly of a Site-Specific Interferon α-Block Copolymer Conjugate into Micelles with Remarkably Enhanced Pharmacology"J. Am. Chem. Soc, 2018, 140, 10435–10438



Xinyu Liu, Jiawei Sun, Weiping Gao. "Site-selective protein modification with polymers for advanced biomedical applications"Biomaterials, 2018, 178, 413-434


Xuelin Wang, Wenhao Yao, Rui Guo, Xiaohu Yang, Jianbo Tang, Jie Zhang, Weiping Gao, Victoria Timchenko, Jing Liu. "Soft and Moldable Mg-Doped Liquid Metal for Conformable Skin Tumor Photothermal Therapy"Adv. Healthcare Mater., 2018, 7, 1800318


Weiping Gao, Mengmeng Sun. "Drug nanorods are potential new nanocarriers for intracellular protein delivery"Theranostics, 2018, 8, 3872-3873


Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang and Weiping Gao. "Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer"Theranostics, 2018, 8, 2634-2645



Xinyu Liu, Jin Hu, Jianwen Guo, Guilin Wang, Weiping Gao. "Temperature-responsive Polymer Conjugation of Interferon-alpha Enhances Antitumor Efficacy"ACTA POLYMERICA SINICA, 2018, 1, 90-98



Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo, Weiping Gao. "Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy"J. Control. Release, 2017, 264, 66-75



Wenguo Zhao, Jin Hu, Weiping Gao. "Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy"ACS Appl. Mater. Interfaces, 2017, 9, 23528–23535



Guilin Wang, Jin Hu, Weiping Gao. "Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy"SCIENCE CHINA Materials 2017, 60, 563-570.



Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao. "Thermally Triggered in Situ Assembly of Gold Nanoparticles for Cancer Multimodal Imaging and Photothermal Therapy"ACS Appl. Mater. Interfaces, 2017, 9, 10453–10460



Linjia Su, Song Hu, Li Zhang, Zhuoran Wang, Weiping Gao, Jing Yuan, Minghua Liu. "A fast and efficient replacement of CTAB with MUA on the surface of gold nanorods assisted by a water-immiscible ionic liquid"Small, 2017, 13, 1602809.



Xinyu Liu, Weiping Gao. "In Situ Growth of Self-Assembled Protein-Polymer Nanovesicles for Enhanced Intracellular Protein Delivery"ACS Appl. Mater. Interfaces, 2017, 9, 2023–2028.



Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao. "In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy". J. Control. Release 2016, 237, 71-77. Note: This paper has been highlighted by Tsinghua University News.



Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao. "Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy". Biomaterials 2016, 96, 84-92. Note: This paper has been highlighted by Tsinghua University News.



孙蒙蒙,王卓然,高卫平. "纳米材料在影像辅助的肿瘤光热治疗中的应用"中国医疗设备, 2016, 6, 24-28.



Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao. "Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer"Nanoscale 2016, 8, 4452-4457.



Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao. "Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha"Adv. Mater. 2015, 27, 320-7324.  Note: This paper has been highlighted by Science China Materials and Tsinghua University News.



Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao. "Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification". Biomaterials 2015, 64, 2-9. Note: This paper has been highlighted by Tsinghua University News.



Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao. "Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects". Chem. Commun. 2015, 51, 11405-11408.


Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao. "Synthesis of well-defined protein-polymer conjugates for biomedicine". Polymer 2015, 66, A1-A10. 



Liao Peng, Huijuan Zhang, Anchao Feng, Meng Huo, Zilin Wang, Jin Hu, Weiping Gao and Jinying Yuan. "Electrochemical redox responsive supramolecular self-healing hydrogels based on host-guest interaction". Polym. Chem. 2015, 6, 3652-3659.


Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao. "Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention". Biomaterials 2015, 47, 13-19.


Bo-wen Liu, Hang Zhou, Si-tong Zhou, Hui-juan Zhang, An-chao Feng, Chun-mei Jian, Jin Hu, Wei-ping Gao, Jin-ying Yuan. "Synthesis of Self-Assembly of CO2-Temperature Dual Stimuli-Responsive Triblock Copolymers”, Macromolecules 2014, 47, 2938-2946.


Liao Peng, Anchao Feng, Huijuan Zhang, Hong Wang, Chunmei Jian, Bowen Liu, Weiping Gao, Jinying Yuan. “Votage-responsive micelles based on the assembly of two biocompatible homopolymers”, Polym. Chem. 2014, 5, 1751-1759.


Yizhi Qi, Miriam Amiram, Weiping Gao, Dewey McCafferty, and Ashutosh Chilkoti. “Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein”, Macromol. Rapid Commun. 2013, 34, 1256-1260.

Before 2012

Weiping Gao, Donghua Xu, Dong Woo Lim, Stephen L. Craig, Ashutosh Chilkoti. “In situ growth of a thermoresponsive polymer of a genetically engineered elastin-like polypeptide”, Polym. Chem., 2011, 2, 1561-1566.


Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti. “In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation”, Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437. Note: This paper has been highlighted by Nature and Science-Business eXchange (SciBX).


Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti. “In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics”, Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236. Note: This paper has been highlighted by media and journals such as Nature, Science Daily, and Science-Business eXchange(SciBX).


Yoshinobu Tsujii, Akihiro Nomura, Kenji. Okayasu, Weiping Gao, Kohji Ohno, Takeshi Fukuda. “AFM studies on microtribology of concentrated polymer brushes in solvents” Journal of Physics: Conference Series 2009, 184, 012031.


Yu Bai, Weiping Gao, Jingjing Yan, Yuguo Ma, Dehai Liang, Zichen Li, Bingyong Han, Wantai Yang, Erqiang Chen. “Co-aggregation process of poly(ethylene oxide)-b-polybutadiene/poly(acrylic acid) based on evolution of interpolymer hydrogen bonding in solutions” Polymer 2008, 49, 2099-2106.


Weiping Gao, Yu Bai, Erqiang Chen, Zichen Li, Bingyong Han, Wantai Yang, Qifeng Zhou. “Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution” Macromolecules 2006, 39, 4894-4898.


Book Chapters

Xinyu Liu, Weiping Gao. “Antibody-Drug Conjugates” Chapter 6 in Biomedical Nanomaterials (eds Y. Zhao and Y. Shen)(2016), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.



Xinyu Liu, Jin Hu, Zhuoran Wang, Zhikun Xu, Weiping Gao. “Polypeptides and Engineered Proteins” Chapter 6 in Advances in Bioinspired and Biomedical Materials Volume 1 (2017), ACS Symposium Series; American Chemical Society: Washington, DC.

Patents

高卫平、胡瑾、王贵林,融合蛋白IFN-ELP及其应用,2016.07,中国,PCT/CN2016/089739

高卫平、孙蒙蒙,类弹性蛋白多肽温度响应性纳米材料及其制备方法与应用,2016.05,中国,201610318098.4

高卫平、胡瑾、王贵林,干扰素高分子结合体IFN-PMPC的制备及其应用, 2016.03,中国,201610169447.0

高卫平,胡瑾,王贵林. 一种制备干扰素高分子结合体IFN-POEGMA的方法, 2015.09,PCT/CN2015/097684

高卫平,胡瑾,王贵林. 一种制备干扰素高分子结合体IFN-POEGMA的方法,2015.10,中国,201510742013.0

高卫平,胡瑾,王贵林. 融合蛋白IFN-ELP及其应用,2015.10,中国,201510471041.3

高卫平,胡瑾,王贵林. 蛋白质-高分子结合体及其制备方法,2014.09,中国,201410478802.3

高卫平,张立彬. 抗体-高分子结合体、其荧光衍生物及它们的制备方法,2014.09,中国,201410480011.4 

Ashutosh Chilkoti, Weiping Gao. “Biomolecule polymer conjugates and methods for making the same”, Date of Patent: Jul. 30, 2013, Patent No.: US8497356B2