Gao lab:Publications

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BioMaterials and NanoMedicine Lab

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Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo, Weiping Gao. "Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy"J. Control. Release, 2017, ASAP


Wenguo Zhao, Jin Hu, Weiping Gao. "Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy"ACS Appl. Mater. Interfaces, 2017, 9, 23528–23535


Guilin Wang, Jin Hu, Weiping Gao. "Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy"SCIENCE CHINA Materials 2017, 60, 563-570.


Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao. "Thermally Triggered in Situ Assembly of Gold Nanoparticles for Cancer Multimodal Imaging and Photothermal Therapy"ACS Appl. Mater. Interfaces, 2017, 9, 10453–10460


Linjia Su, Song Hu, Li Zhang, Zhuoran Wang, Weiping Gao, Jing Yuan, Minghua Liu. "A fast and efficient replacement of CTAB with MUA on the surface of gold nanorods assisted by a water-immiscible ionic liquid"Small, 2017, 13, 1602809.


Xinyu Liu, Weiping Gao. "In Situ Growth of Self-Assembled Protein-Polymer Nanovesicles for Enhanced Intracellular Protein Delivery"ACS Appl. Mater. Interfaces, 2017, 9, 2023–2028.


Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao. "In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy". J. Control. Release 2016, 237, 71-77. Note: This paper has been highlighted by Tsinghua University News.


Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao. "Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy". Biomaterials 2016, 96, 84-92. Note: This paper has been highlighted by Tsinghua University News.


Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao. "Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer"Nanoscale 2016, 8, 4452-4457.

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Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao. "Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha"Adv. Mater. 2015, 27, 320-7324.  Note: This paper has been highlighted by Science China Materials and Tsinghua University News.


Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao. "Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification". Biomaterials 2015, 64, 2-9. Note: This paper has been highlighted by Tsinghua University News.

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Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao. "Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects". Chem. Commun. 2015, 51, 11405-11408.


Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao. "Synthesis of well-defined protein-polymer conjugates for biomedicine". Polymer 2015, 66, A1-A10. 


Liao Peng, Huijuan Zhang, Anchao Feng, Meng Huo, Zilin Wang, Jin Hu, Weiping Gao and Jinying Yuan. "Electrochemical redox responsive supramolecular self-healing hydrogels based on host-guest interaction". Polym. Chem. 2015, 6, 3652-3659.


Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao. "Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention". Biomaterials 2015, 47, 13-19.

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Bo-wen Liu, Hang Zhou, Si-tong Zhou, Hui-juan Zhang, An-chao Feng, Chun-mei Jian, Jin Hu, Wei-ping Gao, Jin-ying Yuan. "Synthesis of Self-Assembly of CO2-Temperature Dual Stimuli-Responsive Triblock Copolymers”, Macromolecules 2014, 47, 2938-2946.


Liao Peng, Anchao Feng, Huijuan Zhang, Hong Wang, Chunmei Jian, Bowen Liu, Weiping Gao, Jinying Yuan. “Votage-responsive micelles based on the assembly of two biocompatible homopolymers”, Polym. Chem. 2014, 5, 1751-1759.


Yizhi Qi, Miriam Amiram, Weiping Gao, Dewey McCafferty, and Ashutosh Chilkoti. “Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein”, Macromol. Rapid Commun. 2013, 34, 1256-1260.

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Before 2012

Weiping Gao, Donghua Xu, Dong Woo Lim, Stephen L. Craig, Ashutosh Chilkoti. “In situ growth of a thermoresponsive polymer of a genetically engineered elastin-like polypeptide”, Polym. Chem., 2011, 2, 1561-1566.


Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti. “In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation”, Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437. Note: This paper has been highlighted by Nature and Science-Business eXchange (SciBX).


Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti. “In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics”, Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236. Note: This paper has been highlighted by media and journals such as Nature, Science Daily, and Science-Business eXchange(SciBX).


Yoshinobu Tsujii, Akihiro Nomura, Kenji. Okayasu, Weiping Gao, Kohji Ohno, Takeshi Fukuda. “AFM studies on microtribology of concentrated polymer brushes in solvents” Journal of Physics: Conference Series 2009, 184, 012031.

Yu Bai, Weiping Gao, Jingjing Yan, Yuguo Ma, Dehai Liang, Zichen Li, Bingyong Han, Wantai Yang, Erqiang Chen. “Co-aggregation process of poly(ethylene oxide)-b-polybutadiene/poly(acrylic acid) based on evolution of interpolymer hydrogen bonding in solutions” Polymer 2008, 49, 2099-2106.


Weiping Gao, Yu Bai, Erqiang Chen, Zichen Li, Bingyong Han, Wantai Yang, Qifeng Zhou. “Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution” Macromolecules 2006, 39, 4894-4898.


Book Chapters

Xinyu Liu, Weiping Gao. “Antibody-Drug Conjugates” Chapter 6 in Biomedical Nanomaterials (eds Y. Zhao and Y. Shen)(2016), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.





高卫平、胡瑾、王贵林,干扰素高分子结合体IFN-PMPC的制备及其应用, 2016.03,中国,201610169447.0

高卫平,胡瑾,王贵林. 一种制备干扰素高分子结合体IFN-POEGMA的方法, 2015.09,PCT/CN2015/097684

高卫平,胡瑾,王贵林. 一种制备干扰素高分子结合体IFN-POEGMA的方法,2015.10,中国,201510742013.0

高卫平,胡瑾,王贵林. 融合蛋白IFN-ELP及其应用,2015.10,中国,201510471041.3

高卫平,胡瑾,王贵林. 蛋白质-高分子结合体及其制备方法,2014.09,中国,201410478802.3

高卫平,张立彬. 抗体-高分子结合体、其荧光衍生物及它们的制备方法,2014.09,中国,201410480011.4 

Ashutosh Chilkoti, Weiping Gao. “Biomolecule polymer conjugates and methods for making the same”, Date of Patent: Jul. 30, 2013, Patent No.: US8497356B2