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BIO254:Silent: Difference between revisions
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==Long-term potentiation== | ==Long-term potentiation== | ||
[[Long-term potentiation]] (LTP) describes the process wherein the synaptic efficacy of two neurons is strengthened over time, in a way that depends on the simultaneity of firing (spike timing dependent plasticity). The best-studied form of this is hippocampal CA3-CA1 LTP, demonstrated by Timothy Bliss and Terje Lomo (1973). Brief high-frequency (tetanic) stimulation of a presynaptic cell can result in long-term enhancement of synaptic transmission. LTP additionally exhibits the following properties: | [[Long-term potentiation|BIO254:LTP]] (LTP) describes the process wherein the synaptic efficacy of two neurons is strengthened over time, in a way that depends on the simultaneity of firing (spike timing dependent plasticity). The best-studied form of this is hippocampal CA3-CA1 LTP, demonstrated by Timothy Bliss and Terje Lomo (1973). Brief high-frequency (tetanic) stimulation of a presynaptic cell can result in long-term enhancement of synaptic transmission. LTP additionally exhibits the following properties: | ||
Cooperativity: The probability of inducing LTP increases with the number of stimulated afferents, and the strength of their stimulation. This reflects a postsynaptic depolarization threshold that must be exceeded in order to induce LTP. | Cooperativity: The probability of inducing LTP increases with the number of stimulated afferents, and the strength of their stimulation. This reflects a postsynaptic depolarization threshold that must be exceeded in order to induce LTP. | ||
