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BIO254:Silent: Difference between revisions
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→The iGluR channel
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Most excitatory synapses in the central nervous system are glutamatergic. In these synapses, glutamate released by the presynaptic cell acts on both metabotropic (mGluR) and ionotropic glutamate receptors (iGluR) in the postsynaptic membrane. Receptors in the iGluR channel can be classified as either NMDA (N-methyl-D-aspartate) or non-NMDA (kainate and AMPA). | Most excitatory synapses in the central nervous system are glutamatergic. In these synapses, glutamate released by the presynaptic cell acts on both metabotropic (mGluR) and ionotropic glutamate receptors (iGluR) in the postsynaptic membrane. Receptors in the iGluR channel can be classified as either NMDA (N-methyl-D-aspartate) or non-NMDA (kainate and AMPA). | ||
Non-NMDA receptors contribute to the early phase of the excitatory postsynaptic current (EPSC) and generate peak current, whereas NMDA receptors contribute to the late phase as a slower component. | Non-NMDA receptors contribute to the early phase of the excitatory postsynaptic current (EPSC) and generate peak current, whereas NMDA receptors contribute to the late phase as a slower component, as can be seen in the image below. This image also shows the effect of APV (see next section) on EPSC. | ||
<div style="margin-left: 60px;">[[Image:iGluR_phases.png]]</div> | <div style="margin-left: 60px;">[[Image:iGluR_phases.png]]</div> | ||
