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BIO254:Silent: Difference between revisions
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→Long-term potentiation
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Associativity: Weak stimulation on one pathway may be insufficient to induce LTP, though when coupled with strong stimulation on another, LTP can be induced on both pathways. | Associativity: Weak stimulation on one pathway may be insufficient to induce LTP, though when coupled with strong stimulation on another, LTP can be induced on both pathways. | ||
It was found that CA3-CA1 LTP requires both NMDAR and CA | It was found that CA3-CA1 LTP requires both NMDAR and CA<sup>2+</sup>. This involves the following steps: depolarization of the postsynaptic cell, activation of NMDA receptors in that cell, the resulting influx of Ca<sup>2+</sup>, and the activation of messengers by Ca<sup>2+</sup>. | ||
The specific expression mechanisms of CA3-CA1 LTP are highly controversial. However, we do know that the expression of LTP is likely to involve both pre- and postsynaptic mechanisms, and that the probability of presynaptic neurotransmitter release is increased after LTP induction. At the postsynaptic cell, AMPA receptors are inserted into the cell membrane, which increases the conductance of the AMPA channel and thereby converts silent synapses into functional ones. | The specific expression mechanisms of CA3-CA1 LTP are highly controversial. However, we do know that the expression of LTP is likely to involve both pre- and postsynaptic mechanisms, and that the probability of presynaptic neurotransmitter release is increased after LTP induction. At the postsynaptic cell, AMPA receptors are inserted into the cell membrane, which increases the conductance of the AMPA channel and thereby converts silent synapses into functional ones. | ||
