Hoatlin Lab

From OpenWetWare
Jump to navigationJump to search

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

Home        Projects        Team        Papers        Contact Us        Protocols        Collaborations        News        Reagent Requests        secret back door        Hoatlin Lab Twitter       



Lab News

For news, follow the Hoatlin lab Twitter


Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Bio for Maureen Hoatlin

Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU). After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers. She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002. Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway. Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds.

Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development.

Teaching Links

  • Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and by Millipore.

PMCB Conjoint Class 2018-2019

Genetic Mechanisms Class (CON662)

Med Students Fundamentals

Biochemistry Seminar Series

Biochemistry Seminar Series and Combined Series Working Draft

Classes of the past

CONJ606/PMCB 2017-2018

Advanced Topics in Molecular Biology(BMB625)

Advanced Topics in Cancer Biology (CANB 610)

OHSU DNA Replication, Recombination and Repair (R3) Club.

Basic Wiki/OWW Links

<wikionly>

Recent changes
List of abbreviations:
N
This edit created a new page (also see list of new pages)
m
This is a minor edit
b
This edit was performed by a bot
(±123)
The page size changed by this number of bytes

20 November 2019

 m   13:53  User:Korey Griffin‎‎ 6 changes history-93[Korey Griffin‎ (6×)]
 m   
13:53 (cur | prev) +4 Korey Griffin talk contribs →‎Genomics
 m   
13:52 (cur | prev) +47 Korey Griffin talk contribs →‎Genomics
 m   
13:52 (cur | prev) -47 Korey Griffin talk contribs →‎Molecular
 m   
13:52 (cur | prev) -2 Korey Griffin talk contribs →‎Methods & Techniques
 m   
13:50 (cur | prev) +30 Korey Griffin talk contribs →‎Methods & Techniques
 m   
12:42 (cur | prev) -125 Korey Griffin talk contribs →‎Empirical Resources
     11:24  Beauchamp:Publications‎‎ 3 changes history+72[Michael S Beauchamp‎ (3×)]
     
11:24 (cur | prev) +1 Michael S Beauchamp talk contribs
     
11:24 (cur | prev) +4 Michael S Beauchamp talk contribs
     
11:22 (cur | prev) +67 Michael S Beauchamp talk contribs
     11:23  (Upload log)[Michael S Beauchamp‎; Dilpreetraju‎ (10×)]
     
11:23 Michael S Beauchamp talk contribs uploaded File:Magnotti Beauchamp PLOS One 2018 InflatedEstimates.pdf
     
10:12 Dilpreetraju talk contribs uploaded File:800RDNew2.png
     
10:12 Dilpreetraju talk contribs uploaded File:RDNew2.png
     
10:09 Dilpreetraju talk contribs uploaded File:800RDNew.png
     
10:08 Dilpreetraju talk contribs uploaded File:RDNew.png
     
10:00 Dilpreetraju talk contribs uploaded File:800PurpleWaste.png
     
10:00 Dilpreetraju talk contribs uploaded File:PurpleWaste.png
     
09:57 Dilpreetraju talk contribs uploaded File:800OctahedralNew.png
     
09:57 Dilpreetraju talk contribs uploaded File:OctahedralNew.png
     
09:47 Dilpreetraju talk contribs uploaded File:800CubicNew.png
     
09:46 Dilpreetraju talk contribs uploaded File:CubicNew.png
N    10:16  User:Raithathar/Notebook/DBR Lab Notebook/2019/11/20‎‎ 2 changes history+982[Raithathar‎ (2×)]
     
10:16 (cur | prev) +32 Raithathar talk contribs →‎Entry title
N    
10:12 (cur | prev) +950 Raithathar talk contribs Autocreate 2019/11/20 Entry for User:Raithathar/Notebook/DBR_Lab_Notebook
N    10:16  User:Raithathar/Notebook/DBR Lab Notebook/2019/11/12‎‎ 2 changes history+1,699[Dilpreetraju‎ (2×)]
     
10:16 (cur | prev) +749 Dilpreetraju talk contribs →‎Entry title
N    
09:36 (cur | prev) +950 Dilpreetraju talk contribs Autocreate 2019/11/12 Entry for User:Raithathar/Notebook/DBR_Lab_Notebook
N    09:57  User:Raithathar/Notebook/DBR Lab Notebook/2019/11/06‎‎ 2 changes history+1,802[Raithathar‎ (2×)]
     
09:57 (cur | prev) +852 Raithathar talk contribs →‎Entry title
N    
09:39 (cur | prev) +950 Raithathar talk contribs Autocreate 2019/11/06 Entry for User:Raithathar/Notebook/DBR_Lab_Notebook
N    09:38  User:Raithathar/Notebook/DBR Lab Notebook/2019/11/05‎‎ 2 changes history+1,947[Raithathar‎ (2×)]
     
09:38 (cur | prev) +997 Raithathar talk contribs →‎Entry title
N    
09:22 (cur | prev) +950 Raithathar talk contribs Autocreate 2019/11/05 Entry for User:Raithathar/Notebook/DBR_Lab_Notebook
N    09:22  User:Raithathar/Notebook/DBR Lab Notebook/2019/11 diffhist +203 Raithathar talk contribs Autocreate Month 2019/11 Entry for User:Raithathar/Notebook/DBR_Lab_Notebook
N    09:21  User:Raithathar/Notebook/DBR Lab Notebook/2019/10/30‎‎ 3 changes history+1,685[Raithathar‎ (3×)]
     
09:21 (cur | prev) 0 Raithathar talk contribs →‎10/30 (Day 12)
     
09:20 (cur | prev) +735 Raithathar talk contribs →‎Entry title
N    
09:15 (cur | prev) +950 Raithathar talk contribs Autocreate 2019/10/30 Entry for User:Raithathar/Notebook/DBR_Lab_Notebook
     07:45  BioMicroCenter:Pricing‎‎ 2 changes history-14[Austin Hendricks‎ (2×)]
     
07:45 (cur | prev) -24 Austin Hendricks talk contribs →‎ILLUMINA LIBRARY - DNA
     
07:44 (cur | prev) +10 Austin Hendricks talk contribs →‎ILLUMINA LIBRARY - DNA

19 November 2019

     20:57  Renhao Li Lab:Publications diffhist +25 Renhao Li talk contribs →‎2019
     19:39  User:Korey Griffin‎‎ 7 changes history-78[Korey Griffin‎ (7×)]
 m   
19:39 (cur | prev) -62 Korey Griffin talk contribs →‎Genomics
 m   
17:38 (cur | prev) 0 Korey Griffin talk contribs →‎Epistemology
 m   
17:38 (cur | prev) -131 Korey Griffin talk contribs →‎Epistemology
 m   
13:32 (cur | prev) +43 Korey Griffin talk contribs →‎Morning Coffee
 m   
12:48 (cur | prev) +81 Korey Griffin talk contribs →‎Morning Coffee
     
12:21 (cur | prev) +2 Korey Griffin talk contribs →‎Coffee Break
 m   
12:20 (cur | prev) -11 Korey Griffin talk contribs →‎Scientific Epistemology
     12:23  Alyssa N Weisblatt Lab Notebook‎‎ 4 changes history+594[Alyssa N. Weisblatt‎ (4×)]
     
12:23 (cur | prev) +2 Alyssa N. Weisblatt talk contribs →‎November 19, 2019: edited position of pictures
     
12:17 (cur | prev) +157 Alyssa N. Weisblatt talk contribs →‎Finding Where the Amplicon and the Clone Sequence Align: added reverse t primer blast comparison
     
12:15 (cur | prev) +278 Alyssa N. Weisblatt talk contribs →‎Finding Where the Amplicon and the Clone Sequence Align: made mismatches underlined
     
11:43 (cur | prev) +157 Alyssa N. Weisblatt talk contribs →‎Finding Where the Amplicon and the Clone Sequence Align: added primer blast picture
     11:46  (Upload log)[Dilpreetraju‎; Alyssa N. Weisblatt‎ (2×)]
     
11:46 Alyssa N. Weisblatt talk contribs uploaded a new version of File:Primer BLAST of amplicon, forward primer, and reverse 1 cropped.png(uploaded smaller version of primer BLAST amplicon, forwards primer, and reverse 1)
     
11:42 Alyssa N. Weisblatt talk contribs uploaded File:Primer BLAST of amplicon, forward primer, and reverse 1 cropped.png(added picture of Primer BLAST results comparing amplicon, forward primer, and reverse 1 primer)
     
11:25 Dilpreetraju talk contribs uploaded File:800 RD2.png
     11:25  User:Raithathar/Notebook/DBR Lab Notebook/2019/10/23 diffhist +113 Dilpreetraju talk contribs →‎10/23-10/29 (Day 11)

</wikionly>