Hoatlin Lab

From OpenWetWare
Jump to navigationJump to search

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

Home        Projects        Team        Papers        Contact Us        Protocols        Collaborations        News        Reagent Requests        secret back door        Hoatlin Lab Twitter       



Lab News

For news, follow the Hoatlin lab Twitter


Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Bio for Maureen Hoatlin

Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU). After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers. She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002. Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway. Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds.

Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development.

Teaching Links

  • Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and by Millipore.

PMCB Conjoint Class 2018-2019

Genetic Mechanisms Class (CON662)

Med Students Fundamentals

Biochemistry Seminar Series

Biochemistry Seminar Series and Combined Series Working Draft

Classes of the past

CONJ606/PMCB 2017-2018

Advanced Topics in Molecular Biology(BMB625)

Advanced Topics in Cancer Biology (CANB 610)

OHSU DNA Replication, Recombination and Repair (R3) Club.

Basic Wiki/OWW Links

<wikionly>

Recent changes
List of abbreviations:
N
This edit created a new page (also see list of new pages)
m
This is a minor edit
b
This edit was performed by a bot
(±123)
The page size changed by this number of bytes

26 September 2020

     13:47  Nathan R Beshai Week 4‎‎ 4 changes history +1,237 [Nathan R. Beshai‎ (4×)]
     
13:47 (cur | prev) +1,074 Nathan R. Beshai talk contribs added what Genbank says about SARS coronavirus Urbani
     
13:30 (cur | prev) +90 Nathan R. Beshai talk contribs added sequence for chosen pdf
     
13:13 (cur | prev) 0 Nathan R. Beshai talk contribs changed formatting
     
13:13 (cur | prev) +73 Nathan R. Beshai talk contribs added rendered phylogenetic tree
     13:25  (Upload log) [Michael S Beauchamp‎; Nathan R. Beshai‎ (2×)]
     
13:25 Nathan R. Beshai talk contribs uploaded File:SARS coronavirus Urbani, complete genome.pdf(added chosen sequence)
     
13:11 Nathan R. Beshai talk contribs uploaded File:Nathan Week4Phylogenetictree.png(added phylogenetic tree)
     
11:30 Michael S Beauchamp talk contribs uploaded File:Metzger et al JNeurosci 2020 v2.pdf
     11:28  Beauchamp:Publications diffhist +3 Michael S Beauchamp talk contribs
     08:52  Ernesto-Perez-Rueda:Publications diffhist +74 Ernesto Perez-Rueda talk contribs
     07:57  Renhao Li Lab:Publications diffhist +66 Renhao Li talk contribs →‎2020
 m   05:43  Forster Lab diffhist +9 Anthony C. Forster talk contribs

25 September 2020

     16:51  Min-Ho Kim Lab:Publications diffhist +204 Min-Ho Kim talk contribs
     13:42  Qin:Lab Members diffhist +1 Yaning talk contribs →‎Hejian Xiong
     13:41  Qin:Research diffhist -10 Yaning talk contribs →‎Point-of-care diagnosis for infectious diseases
 m   13:20  Griffin:Nested RT-PCR‎‎ 11 changes history +2,286 [Korey Griffin‎ (11×)]
 m   
13:20 (cur | prev) +153 Korey Griffin talk contribs →‎PCR Optimization
 m   
13:17 (cur | prev) +224 Korey Griffin talk contribs →‎DNA Contamination
 m   
12:52 (cur | prev) 0 Korey Griffin talk contribs →‎PCR Optimization
 m   
12:52 (cur | prev) +102 Korey Griffin talk contribs →‎PCR Optimization
 m   
12:51 (cur | prev) +655 Korey Griffin talk contribs →‎-/+ Reverse Transcriptase
 m   
12:23 (cur | prev) +149 Korey Griffin talk contribs →‎DNA Contamination
 m   
12:06 (cur | prev) 0 Korey Griffin talk contribs →‎DNA Contamination
 m   
12:06 (cur | prev) +68 Korey Griffin talk contribs →‎DNA Contamination
 m   
12:03 (cur | prev) +56 Korey Griffin talk contribs →‎DNA Contamination
 m   
12:01 (cur | prev) +33 Korey Griffin talk contribs →‎DNA Contamination
 m   
12:00 (cur | prev) +846 Korey Griffin talk contribs →‎PCR Optimization
     11:13  CAMRI:SeminarSeries diffhist +63 Michael S Beauchamp talk contribs

24 September 2020

N    18:18  Ian R. Wright Week 4 diffhist +1,119 BallonaBuddy talk contribs starting references
     17:33  Yaniv Maddahi Journal Week 4‎‎ 6 changes history +28,212 [Yaniv Maddahi‎ (6×)]
     
17:33 (cur | prev) +9,015 Yaniv Maddahi talk contribs Added spaces and cluster sequence
     
17:23 (cur | prev) +57 Yaniv Maddahi talk contribs Added phylogenetic tree
     
17:18 (cur | prev) +12 Yaniv Maddahi talk contribs Added template header
     
17:17 (cur | prev) -1 Yaniv Maddahi talk contribs fixed a space for title
     
17:17 (cur | prev) +1 Yaniv Maddahi talk contribs Fixed a space in it
     
17:16 (cur | prev) +19,128 Yaniv Maddahi talk contribs Added all spike sequences
     17:32  Macie Duran Week 4‎‎ 2 changes history +29,518 [Macie Duran‎ (2×)]
     
17:32 (cur | prev) +3 Macie Duran talk contribs →‎Clustal Alignment of Spike Protein Sequences: fixed spacing errors in sequence alignment
     
17:30 (cur | prev) +29,515 Macie Duran talk contribs →‎Method & Results: added aligned sequences
     17:28  Nathan R Beshai Week 4 diffhist +29,552 Nathan R. Beshai talk contribs added sequences and spaces
     17:25  (Upload log) [Yaniv Maddahi‎; Jcorrey‎]
     
17:25 Jcorrey talk contribs uploaded File:CorreyPhyloTree.JPG
     
17:23 Yaniv Maddahi talk contribs uploaded File:Maddahi phylo tree.png
     17:25  Owen R. Dailey Week 4 diffhist -1,938 Owen R. Dailey talk contribs →‎Part 1: GenBank: Added more materials/results
N    17:21  BIOL368/S19 Week 4‎‎ 2 changes history +27,499 [Falghane‎ (2×)]
     
17:21 (cur | prev) +15 Falghane talk contribs space sequance 1
N    
17:05 (cur | prev) +27,484 Falghane talk contribs multiple sequence alignment added
N    17:21  JT Correy Journal Week 4‎‎ 3 changes history +29,549 [Jcorrey‎ (3×)]
     
17:21 (cur | prev) +24 Jcorrey talk contribs formatting
     
17:20 (cur | prev) +360 Jcorrey talk contribs formatting
N    
17:14 (cur | prev) +29,165 Jcorrey talk contribs added sequences
     17:11  BIOL368/F20:Week 4‎‎ 4 changes history +393 [Nathan R. Beshai‎; Macie Duran‎ (3×)]
     
17:11 (cur | prev) -1 Macie Duran talk contribs →‎Data & Tools
     
17:09 (cur | prev) +20 Macie Duran talk contribs →‎Data & Tools: Macie Duran added accession numbers to link labels
     
17:07 (cur | prev) +190 Macie Duran talk contribs →‎Data & Tools: Macie Duran added links to sequences
     
16:54 (cur | prev) +184 Nathan R. Beshai talk contribs added sequences
     17:09  Aiden Burnett Week 4 diffhist +1,072 Aiden Burnett talk contribs →‎Methods & Results: added text
     17:06  Talk:BIOL368/F20:Week 4 diffhist +1,355 Aiden Burnett talk contribs added text

</wikionly>