Hoatlin Lab

From OpenWetWare
(Redirected from Hoatlin)
Jump to navigationJump to search

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

Home        Projects        Team        Papers        Contact Us        Protocols        Collaborations        News        Reagent Requests        secret back door        Hoatlin Lab Twitter       

Lab News

For news, follow the Hoatlin lab Twitter

Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Bio for Maureen Hoatlin

Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU). After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers. She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002. Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway. Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds.

Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development.

Teaching Links

  • Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and by Millipore.

PMCB Conjoint Class 2018-2019

Genetic Mechanisms Class (CON662)

Med Students Fundamentals

Biochemistry Seminar Series

Biochemistry Seminar Series and Combined Series Working Draft

Classes of the past

CONJ606/PMCB 2017-2018

Advanced Topics in Molecular Biology(BMB625)

Advanced Topics in Cancer Biology (CANB 610)

OHSU DNA Replication, Recombination and Repair (R3) Club.

Basic Wiki/OWW Links


Recent changes
List of abbreviations:
This edit created a new page (also see list of new pages)
This is a minor edit
This edit was performed by a bot
The page size changed by this number of bytes

14 June 2024

N    12:55  UA Biophysics:Peptides and IA‎‎ 3 changes history +1,837 [Elizabeth Suesca‎ (3×)]
12:55 (cur | prev) +44 Elizabeth Suesca talk contribs
12:54 (cur | prev) −68 Elizabeth Suesca talk contribs
12:45 (cur | prev) +1,861 Elizabeth Suesca talk contribs (Created page with "Debido a la rápida aparición de mecanismos de resistencia a antibióticos en diferentes microorganismos patógenos potencialmente mortales a nivel mundial, existe un gran interés en la identificación de agentes antimicrobianos alternativos que puedan ayudar en el desarrollo de nuevas estrategias de tratamiento. Mediante la aplicación de una rutina de Deep Learning, desarrollada y publicada por el grupo de investigación proponente, se predecirá una lista de candida...")
     12:45  Biophysics‎‎ 3 changes history +204 [Elizabeth Suesca‎ (3×)]
12:45 (cur | prev) +4 Elizabeth Suesca talk contribs
12:44 (cur | prev) +1 Elizabeth Suesca talk contribs
12:29 (cur | prev) +199 Elizabeth Suesca talk contribs

13 June 2024

     14:39 User creation log User account Yannvrb talk contribs was created by Yar talk contribs and password was sent by email ‎
     13:57  Magni:Back Door‎‎ 2 changes history +199 [Lorenzo Pasotti‎ (2×)]
13:57 (cur | prev) +151 Lorenzo Pasotti talk contribs
13:54 (cur | prev) +48 Lorenzo Pasotti talk contribs (→‎E. coli strains)
     08:28  WAKNA:Basics‎‎ 3 changes history −73 [Berthold Drexler‎ (3×)]
08:28 (cur | prev) −204 Berthold Drexler talk contribs (→‎Hier finden Sie Literatur für Einsteiger:innen in das Gebiet der Neuroanästhesie)
08:26 (cur | prev) 0 Berthold Drexler talk contribs (→‎Hier finden Sie Literatur für Einsteiger:innen in das Gebiet der Neuroanästhesie)
08:26 (cur | prev) +131 Berthold Drexler talk contribs (→‎halbsitzende Lagerung und Luftembolie)

12 June 2024

N    13:10  Karas Lab:YAEL Electrode Localization‎‎ 2 changes history +859 [Aclesage‎ (2×)]
13:10 (cur | prev) +585 Aclesage talk contribs
13:08 (cur | prev) +274 Aclesage talk contribs (Created page with "<b>Y</b>our <b>A</b>dvanced <b>E</b>lectrode <b>L</b>ocalizer (YAEL) is free and open-source software for localizing and visualizing electrodes. YAEL is a sister package to the RAVE software toolbox for the analysis of intracranial electroencephalogram (iEEG) data.")
     13:04  Karas Lab:Lab Notebook‎‎ 2 changes history +48 [Aclesage‎ (2×)]
13:04 (cur | prev) 0 Aclesage talk contribs
13:00 (cur | prev) +48 Aclesage talk contribs
     06:13  Hu:Publications diffhist +33 Hugangqing talk contribs
     06:12  Hu diffhist +44 Hugangqing talk contribs

11 June 2024

N    19:16  BioMicroCenter:PricingFY2025 diffhist +28,119 Stuart S. Levine talk contribs (Created page with "''' PRICING UPDATE 7/1/2024 ''' == SEQUENCING == Please note that samples submitted from '''CORE LAB'''s will be given priority on all equipment. The BioMicro Center reserves the right to reject samples for any reason. <BR><BR> === NOVASEQ SEQUENCING === {| class="wikitable" border=1  ! NOVASEQ SEQUENCING !width=80| CORE LAB !width=80| MIT !width=80| Non-MIT !width=80| uni...")
     18:40  BioMicroCenter:Pricing diffhist +54 Stuart S. Levine talk contribs (→‎COMPUTATIONAL SERVICES)
     08:18  Forster Lab‎‎ 2 changes history +153 [Anthony C. Forster‎ (2×)]
08:18 (cur | prev) +4 Anthony C. Forster talk contribs (→‎The Boss!?)
08:16 (cur | prev) +149 Anthony C. Forster talk contribs (→‎The Boss!?)
     08:03  Pecreaux diffhist −1,628 Cedre-PecreauxLab talk contribs (→‎News!)