Hoatlin Lab

From OpenWetWare
(Redirected from Hoatlin)
Jump to navigationJump to search

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

Home        Projects        Team        Papers        Contact Us        Protocols        Collaborations        News        Reagent Requests        secret back door        Hoatlin Lab Twitter       



Lab News

For news, follow the Hoatlin lab Twitter


Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Bio for Maureen Hoatlin

Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU). After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers. She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002. Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway. Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds.

Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development.

Teaching Links

  • Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and by Millipore.

PMCB Conjoint Class 2018-2019

Genetic Mechanisms Class (CON662)

Med Students Fundamentals

Biochemistry Seminar Series

Biochemistry Seminar Series and Combined Series Working Draft

Classes of the past

CONJ606/PMCB 2017-2018

Advanced Topics in Molecular Biology(BMB625)

Advanced Topics in Cancer Biology (CANB 610)

OHSU DNA Replication, Recombination and Repair (R3) Club.

Basic Wiki/OWW Links

<wikionly>

Recent changes
List of abbreviations:
N
This edit created a new page (also see list of new pages)
m
This is a minor edit
b
This edit was performed by a bot
(±123)
The page size changed by this number of bytes

24 April 2019

     21:32 

3D Printing Techniques-Hanna Scher‎‎ (2 changes | history) . . (+62). . [Hscher‎ (2×)]

     

21:32

(cur | prev) . . (-1). . Hscher (talk | contribs) (Fused Deposition (Extrusion) Printing)

     

21:27

(cur | prev) . . (+63). . Hscher (talk | contribs) (Fused Deposition (Extrusion) Printing)

     21:31 (Upload log) . . Hscher (talk | contribs) uploaded File:Mechanical Characterization of PDMS Samples.JPG

     21:30 

3D Printing Materials-Hanna Scher‎‎ (6 changes | history) . . (+2,063). . [Hscher‎ (6×)]

     

21:30

(cur | prev) . . (-1). . Hscher (talk | contribs)

     

21:17

(cur | prev) . . (+2,064). . Hscher (talk | contribs)

     

21:09

(cur | prev) . . (-74). . Hscher (talk | contribs) (3D Printing of Polydimethylsiloxane)

     

21:09

(cur | prev) . . (+1). . Hscher (talk | contribs) (3D Printing of Polydimethylsiloxane)

     

21:08

(cur | prev) . . (+3). . Hscher (talk | contribs) (3D Printing of Polydimethylsiloxane)

     

21:07

(cur | prev) . . (+70). . Hscher (talk | contribs) (3D Printing of Polydimethylsiloxane)

     18:38  Lee:JC‎ (diff | hist) . . (-2). . Wooin Lee (talk | contribs) (Lab meeting schedule)

     16:04 

BIOL478/S19:Microarray Data Analysis‎‎ (10 changes | history) . . (+810). . [Kam D. Dahlquist‎ (10×)]

     

16:04

(cur | prev) . . (+79). . Kam D. Dahlquist (talk | contribs) (Modified t test for each timepoint: modify tdist equation)

     

15:48

(cur | prev) . . (+1). . Kam D. Dahlquist (talk | contribs) (Modified t test for each timepoint: add paren)

     

11:48

(cur | prev) . . (+65). . Kam D. Dahlquist (talk | contribs) (Summary list of files you need to turn in to your folder in Box: clarify steps)

     

11:46

(cur | prev) . . (+656). . Kam D. Dahlquist (talk | contribs) (Visualizing Your Gene Regulatory Network with GRNsight: add list of files)

     

11:41

(cur | prev) . . (-19). . Kam D. Dahlquist (talk | contribs) (Identifying regulatory transcription factors responsible for observed changes in gene expression (step 10): clarified a couple of things)

     

11:38

(cur | prev) . . (+32). . Kam D. Dahlquist (talk | contribs) (Visualizing Your Gene Regulatory Network with GRNsight: mention grid layout)

     

11:36

(cur | prev) . . (-2). . Kam D. Dahlquist (talk | contribs) (Comparing results with known data (step 7): elevating heading level)

     

11:36

(cur | prev) . . (0). . Kam D. Dahlquist (talk | contribs) (Clustering and GO Term Enrichment with stem (steps 7-8): changings step number)

     

11:35

(cur | prev) . . (+7). . Kam D. Dahlquist (talk | contribs) (Comparing results with known data: elevating level)

     

11:34

(cur | prev) . . (-9). . Kam D. Dahlquist (talk | contribs) (Clustering and GO Term Enrichment with stem (steps 7-8): change ASH1 to HMO1, uncomment YEASTRACT/GRNsight)

     15:49 

Austindias Week 12‎‎ (3 changes | history) . . (+112). . [Austindias‎ (3×)]

     

15:49

(cur | prev) . . (+73). . Austindias (talk | contribs) (Conclusion: saved initial conclusion)

     

15:46

(cur | prev) . . (-10). . Austindias (talk | contribs) (Results: deleted unnecessary line)

     

15:32

(cur | prev) . . (+49). . Austindias (talk | contribs) (saved parameters found in Tai paper)

     15:48  User:Hoang D. Lu‎ (diff | hist) . . (+7). . Hoang D. Lu (talk | contribs) (Select Publications)
     15:29  BIOL388/S19:Class Journal Week 12‎ (diff | hist) . . (+344). . Austindias (talk | contribs) (saved reflection)

     15:10 

Alison S King Week 12‎‎ (5 changes | history) . . (+912). . [Alison S King‎ (5×)]

     

15:10

(cur | prev) . . (+302). . Alison S King (talk | contribs) (References: referenc)

     

11:54

(cur | prev) . . (+67). . Alison S King (talk | contribs) (Answers from Literature: answered some)

     

11:27

(cur | prev) . . (+48). . Alison S King (talk | contribs) (Answers from Literature: wrote parameters)

     

11:25

(cur | prev) . . (+161). . Alison S King (talk | contribs) (Answers from Literature: answered some)

     

11:12

(cur | prev) . . (+334). . Alison S King (talk | contribs) (Answers from Literature: converted units)

     13:19 (User creation log) . . User account Zhengjia (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     12:30 

McClean:KS Amino Acid Supplement‎‎ (2 changes | history) . . (+360). . [Lauterjung‎ (2×)]

     

12:30

(cur | prev) . . (+183). . Lauterjung (talk | contribs)

     

12:23

(cur | prev) . . (+177). . Lauterjung (talk | contribs) (Final Composition in Liquid Media)

     10:56  Schumer lab: Commonly used workflows‎ (diff | hist) . . (+2). . Schumer (talk | contribs) (Ancestry tsv files to rQTL input)
     10:08  BioMicroCenter:BIG meeting‎ (diff | hist) . . (-1). . Huiming Ding (talk | contribs) (2018-2019 academic year)

23 April 2019

     21:20 

Alison S King Week 12‎‎ (2 changes | history) . . (+1,020). . [Alison S King‎ (2×)]

     

21:20

(cur | prev) . . (+541). . Alison S King (talk | contribs) (Answers from Literature: answered some)

     

16:40

(cur | prev) . . (+479). . Alison S King (talk | contribs) (References: reference for assignment page and Tai)

     17:48 

Nannochloropsis genetic elements‎‎ (3 changes | history) . . (+433). . [Poli‎ (3×)]

     

17:48

(cur | prev) . . (0). . Poli (talk | contribs) (Codon optimization)

     

17:48

(cur | prev) . . (+387). . Poli (talk | contribs) (Codon optimization)

     

17:24

(cur | prev) . . (+46). . Poli (talk | contribs) (Localization peptides)

     17:24 (User creation log) . . User account CoryCasikenquirm (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

N    16:53 

Angela C Abarquez Week 12‎‎ (6 changes | history) . . (+471). . [Angela C Abarquez‎ (6×)]

     

16:53

(cur | prev) . . (+58). . Angela C Abarquez (talk | contribs) (added second file)

     

16:51

(cur | prev) . . (0). . Angela C Abarquez (talk | contribs) (edit format)

     

16:51

(cur | prev) . . (+2). . Angela C Abarquez (talk | contribs) (edit file format)

     

16:50

(cur | prev) . . (+80). . Angela C Abarquez (talk | contribs) (added wiki file)

     

16:48

(cur | prev) . . (+105). . Angela C Abarquez (talk | contribs) (added link to box)

N    

16:44

(cur | prev) . . (+226). . Angela C Abarquez (talk | contribs) (added headers)

     16:52 

(Upload log). .

[Angela C Abarquez‎ (2×)]

     

16:52

. . Angela C Abarquez (talk | contribs) uploaded File:AA chemostat 2nutrient script.m.zip(script MATLAB file)

     

16:49

. . Angela C Abarquez (talk | contribs) uploaded File:AA chemostat 2nutrient dynamics.m.zip(Matlab dynamics file)

     16:42  Template:Angela C Abarquez‎ (diff | hist) . . (+156). . Angela C Abarquez (talk | contribs) (added week 12)

</wikionly>