Hoatlin Lab

From OpenWetWare
(Redirected from Hoatlin)
Jump to navigationJump to search

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

Home        Projects        Team        Papers        Contact Us        Protocols        Collaborations        News        Reagent Requests        secret back door        Hoatlin Lab Twitter       



Lab News

For news, follow the Hoatlin lab Twitter


Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Bio for Maureen Hoatlin

Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU). After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers. She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002. Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway. Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds.

Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development.

Teaching Links

  • Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and by Millipore.

PMCB Conjoint Class 2018-2019

Genetic Mechanisms Class (CON662)

Med Students Fundamentals

Biochemistry Seminar Series

Biochemistry Seminar Series and Combined Series Working Draft

Classes of the past

CONJ606/PMCB 2017-2018

Advanced Topics in Molecular Biology(BMB625)

Advanced Topics in Cancer Biology (CANB 610)

OHSU DNA Replication, Recombination and Repair (R3) Club.

Basic Wiki/OWW Links

<wikionly>

Recent changes
List of abbreviations:
N
This edit created a new page (also see list of new pages)
m
This is a minor edit
b
This edit was performed by a bot
(±123)
The page size changed by this number of bytes

3 December 2022

     12:46  Silver: 2023 Meeting Schedule‎‎ 6 changes history −417 [PamSilver‎ (6×)]
     
12:46 (cur | prev) −4 PamSilver talk contribs
     
12:41 (cur | prev) +9 PamSilver talk contribs
     
12:41 (cur | prev) +13 PamSilver talk contribs
     
12:38 (cur | prev) +17 PamSilver talk contribs
     
12:32 (cur | prev) −52 PamSilver talk contribs
     
12:29 (cur | prev) −400 PamSilver talk contribs
     11:58 Move log PamSilver talk contribs moved page Silver: 2022 Meeting Schedule to Silver: 2023 Meeting Schedule

2 December 2022

     10:12  Schumer lab:Lab Meetings‎‎ 6 changes history +2,616 [Tododge‎ (6×)]
     
10:12 (cur | prev) −2 Tododge talk contribs (→‎Lab meeting/coffee hour schedule winter quarter 2022)
     
09:57 (cur | prev) +648 Tododge talk contribs (→‎Lab meeting/coffee hour schedule fall quarter 2022)
     
09:47 (cur | prev) +1,642 Tododge talk contribs (→‎Lab meeting/coffee hour schedule summer quarter 2022 (biweekly-ish schedule))
     
09:21 (cur | prev) −2 Tododge talk contribs (→‎Lab meeting/coffee hour schedule summer quarter 2022 (biweekly-ish schedule))
     
09:21 (cur | prev) +110 Tododge talk contribs (→‎Lab meeting/coffee hour schedule summer quarter 2022 (biweekly-ish schedule))
     
09:18 (cur | prev) +220 Tododge talk contribs (→‎Lab meeting/coffee hour schedule summer quarter 2022 (biweekly-ish schedule))
     09:57  Schumer lab: Commonly used scripts‎‎ 3 changes history +975 [Schumer‎ (3×)]
     
09:57 (cur | prev) +313 Schumer talk contribs (→‎Scripts that manipulate or summarize fasta files)
     
09:43 (cur | prev) +343 Schumer talk contribs (→‎Scripts for managing fastq files)
     
09:35 (cur | prev) +319 Schumer talk contribs (→‎Scripts for managing fastq files)
N    09:14  RAVE:realtime‎‎ 3 changes history +358 [Michael S Beauchamp‎ (3×)]
     
09:14 (cur | prev) +20 Michael S Beauchamp talk contribs
     
08:58 (cur | prev) +315 Michael S Beauchamp talk contribs
N    
08:55 (cur | prev) +23 Michael S Beauchamp talk contribs (Created page with "{{RAVE_Navigation_Bar}}")
     08:55  RAVE:ravemodules‎‎ 2 changes history +84 [Michael S Beauchamp‎ (2×)]
     
08:55 (cur | prev) −6 Michael S Beauchamp talk contribs
     
08:54 (cur | prev) +90 Michael S Beauchamp talk contribs (→‎Typical workflow)

1 December 2022

 m   23:50  User:Shantanu Ghosh diffhist +17 Shantanu Ghosh talk contribs
     12:34  Chenlab:Publications diffhist −4 Kaifu Chen talk contribs
 m   08:29  Griffin:Immunofluorescence Cell Staining‎‎ 4 changes history +1,412 [Korey Griffin‎ (4×)]
 m   
08:29 (cur | prev) −1 Korey Griffin talk contribs (→‎Paraformaldehyde (PFA)=)
 m   
08:28 (cur | prev) 0 Korey Griffin talk contribs (→‎Formalin)
 m   
08:28 (cur | prev) +10 Korey Griffin talk contribs (→‎Paraformaldehyde (PFA)=)
 m   
08:27 (cur | prev) +1,403 Korey Griffin talk contribs (→‎Formaldehyde fixation)
 m   08:03  User:Korey Griffin‎‎ 2 changes history +9 [Korey Griffin‎ (2×)]
 m   
08:03 (cur | prev) −3 Korey Griffin talk contribs (→‎Procedure)
 m   
08:02 (cur | prev) +12 Korey Griffin talk contribs (→‎Procedure)

30 November 2022

     19:01  Eccles: Lab meeting schedule diffhist +316 MikeEccles talk contribs (→‎Lab meeting schedule)
     18:23  User:Gareth Trubl‎‎ 3 changes history +193 [Gtrubl‎ (3×)]
     
18:23 (cur | prev) +32 Gtrubl talk contribs (→‎About me & research interests)
     
18:21 (cur | prev) −1 Gtrubl talk contribs (→‎About me & research interests)
     
18:21 (cur | prev) +162 Gtrubl talk contribs (→‎About me & research interests)
 m   14:50  Griffin:Chromatin Immunoprecipitation‎‎ 6 changes history +1,274 [Korey Griffin‎ (6×)]
 m   
14:50 (cur | prev) +123 Korey Griffin talk contribs (→‎(NGS) Next Generation Sequencing)
 m   
14:34 (cur | prev) +77 Korey Griffin talk contribs (→‎(NGS) Next Generation Sequencing)
 m   
13:47 (cur | prev) +223 Korey Griffin talk contribs (→‎ChIP-Seq)
 m   
13:25 (cur | prev) +176 Korey Griffin talk contribs (→‎ChIP-Seq)
 m   
13:19 (cur | prev) 0 Korey Griffin talk contribs (→‎CHIP Terminology & Prep Summary)
 m   
13:19 (cur | prev) +675 Korey Griffin talk contribs (→‎CHIP)
 m   14:45  User:Korey Griffin diffhist +46 Korey Griffin talk contribs (→‎Literature)
     13:09  RAVE:LocalizeElectrodes‎‎ 9 changes history +395 [Michael S Beauchamp‎ (9×)]
     
13:09 (cur | prev) +112 Michael S Beauchamp talk contribs
     
13:07 (cur | prev) −57 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     
13:07 (cur | prev) +6 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     
13:06 (cur | prev) +3 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     
13:06 (cur | prev) +3 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     
13:06 (cur | prev) −2 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     
13:05 (cur | prev) −21 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     
13:05 (cur | prev) +151 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     
13:02 (cur | prev) +200 Michael S Beauchamp talk contribs (→‎Localizing electrodes in RAVE)
     13:07 Upload log Michael S Beauchamp talk contribs uploaded File:ELECTRODE LOCALIZATION SOP.pdf

</wikionly>