User:Mohammad H. Dezfulian

Contact Info Mohammad Dezfulian W: Harvard Scholar Patents Methods And Compositions for Identifying Epitopes. WO/2018/227091 Link This patent describes the development of TScan-I and TScan-II platforms, which are the core innovations at TScan Therapeutics. Publications Search Pubmed for an updated list of publications Peer Reviewed 1. Sardari, S. and Dezfulian, MH. (2005) Evaluation of SAR for Amphotericin B Derivatives by Artificial Neural Network. Tropical Journal of Pharmaceutical Research PDF 2. Sardari, S. and Dezfulian, MH. (2007) Cheminformatics in anti-infective agent discovery. Mini Review in Medicinal Chemistry PDF 3. Dezfulian, MH. Soulliere, DM. Dhaliwal, RK. Sareen, M. Crosby, WL. (2012) The SKP1-Like Gene Family of Arabidopsis Exhibits a High Degree of Differential Gene Expression and Gene Product Interaction during Development. Plos One, Link 4. Maleki, M. Dezfulian MH. Rueda, L. A Computational Domain-Based Feature Grouping Approach for Prediction of Stability of SCF Ligases. (2015) Bioinformatics and Biomedical Engineering Link 5. Khalili, S. Rahbar, MR. Dezfulian, MH. Jahangiri, A. In silico analyses of Wilms’ tumor protein to designing a novel multi-epitope DNA vaccine against cancer. (2015) Journal of Theoretical Biology Link PDF 6. Dezfulian, MH. Jalili, E. Roberto, D.K.A. Moss, B.M. Khoo, K. Nemhauser, J.L. Crosby W.L. Oligomerization of SCF TIR1 is essential for Aux/IAA degridation and Auxin signaling in Arabidopsis. (2016) PLoS Genetics Link 7. Dezfulian, MH. Foreman, C. Jalili, E. Pal, M. Dhaliwal, R. K. Roberto, D.K. Crosby, W.L. Acetolactate synthase regulatory subunits play divergent and overlapping roles in branched-chain amino acid synthesis and Arabidopsis development. (2017) BMC Plant Biology Link 8. Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ: T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. (2019) Cell Link Highlighted in Science Translational Medicine & Nature Methods Trends in Immunology 9. Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala DC,Ferrer E, Conahan C, Del Pino SP, Grossman J, Elledge S, Hidalgo M, Muthuswamy SK. Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids (2021) Journal for Immunotherapy of Cancer Link 10. Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian MH, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. (2021) Genes and Development Link 11.Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi A, Joachims ML, Chiorini JA, Lessard C, Farris AD, Muthuswamy S, Warner BA, Elledge SJ. TScan-II: A genome-scale platform for de novo identification of CD4+ T cell epitopes. (2023) Cell Highlighted in Nature Methods & Cell Reports Medicine & Cancer Immunology Research 12. Kohlgruber, A.C., Dezfulian, M.H., Sie, B.M., Wang, C.I., Kula, T., Laserson, U., Larman, H.B. and Elledge, S.J. High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits (2024) Nature Biotechnology Non Peer Reviewed 1. Sardari, S. and Dezfulian, MH. The Eastern Mediterranean Health Genomics and Biotechnology Network Critical for the Region. (2006) Genetic Engineering News Link Academic Honors 2023 Poster presentation award at Salivary Glands and Exocrine Biology Gordon Research Conference, CA, USA 2012 Conference Travel Award,University of Windsor, Department of Graduate Studies 2011-2012 Graduate Student Society Award University of Windsor, Graduate Student Society 2010-2011 International Student Society Award University of Windsor, International student of the year award 2009-2010 Department of Biological Sciences Graduate Excellence Award University of Windsor, Excellence in Research 2008-2012 Graduate Excellence Scholarship University of Windsor, Department of Graduate Studies 2008 Conference Travel Award University of Windsor, Department of Graduate Studies Fellowships 2012-2013 Queen Elizabeth II Graduate Scholarship in Science and Technology 2008-2012 Agriculture and Agri-Food Canada Graduate Student Scholarship 2006-2012 International Graduate Scholarship University of Windsor, Department of Graduate Studies Funding Systemic Profiling of SCF E3 Ligase Regulatory Attributes at Play in Cell Cycle Control and Cancer (Co-investigator) Seeds4Hope (2014-2016) Molecular Regulation of Auxin Signaling in Plant Development (Co-investigator) NSERC (2015-2020) Mapping the specificity of CD4+ lymphocytes in Sjögren’s disease (Principle Investigator) 2022-2024 Sjögren’s Foundation High Impact Research Grant Conference Presentations & Proceedings 1. Bioactivity and chemical informatics of modeled microtubule inhibitors: Identification of key features and design of new agents in the treatment of cancer. (2005) Sardari, S. Dezfulian, MH. TETRAHEDRON SYMPOSIUM 2005 Challenges in Organic Chemistry, Paris 2. Synthetic strategies in protecting group selection and compound library design by informatics modeled group chemistry and neural networking. (2005) Sardari, S. Zolfaghari Jooya, H. Dezfulian MH. Omidi, M. TETRAHEDRON SYMPOSIUM 2005 Challenges in Organic Chemistry, Paris 3. Molecular informatics, QSPR and computer modeling of microtubule inhibitors: Identification of key features and design of new agents in the treatment of tuberculosis. (2005) Dezfulian, MH. Sardari, S. 34th International Scientific Meeting of the Directors of Pasteur Institute, Tehran 4. QSPR modeling of Gyrase inhibitors of Trypanosoma: Identification of new agents. (2005) Dezfulian, MH. Jalili, E. Sardari, S. First National Congress on Molecular Microbiology Karaj 5. A computer based model for anti Topoisomearse II compounds, a novel approach for evaluation of anti-cancer drugs. (2005) Dezfulian, MH. Jalili, E. Sardari, S. First International Congress of Biology & 13th National Congress of Biology, Rasht 6. Artificial Neural Networks in Cheminformatics.* (2005) Dezfulian, MH. Research Day, Chamran, University of Ahvaz Invited Speaker 7. Molecular Modelling of Methionyl-tRNA Synthetase Inhibitors in Staphylococcus aureus. (2005) Jalili, E. Dezfulian MH. Sardari, S. 1st Student Conference of Biotechnology, Tehran 8. A screening study of hereditary nonpolyposis colorectal cancer (HNPCC), by Microsatellite marker analysis in Khorasan Province of Iran. (2006) Ahmadi, A. Galehdari, H. Dezfulian, MH. International Medical Genetic Conference, Kuwait 9. A Neural Network based model for evaluation of Anti-malarial Drugs. (2006) Sardari, S. Galehdari, H. Jalili, E. Dezfulian, MH. International Pharmaceutical Sciences Congress, Tehran 10. Functional Analysis of SKP1 genes in Arabidopsis thaliana. (2008) Dezfulian, MH. Crosby, WL. 19th International Conference on Arabidopsis Research , Montreal Abstract 11. From Protein Complex to Supra-Complex. (2011) Crosby, WL. Dezfulian, MH. Dinatale, C. International Conference on Biomedical Ontology (ICBO), Buffalo, NY PPT 12. E3-Ubiquitin Ligases as a Use-Case Scenario For Developing Quaternary Protein Complex Ontologies (2012) Crosby, WL. Dezfulian, MH. Dinatale, C. Plant and Animal Genome XX Conference, San Diego Abstract 13. Identification of Ubiquitinated proteins in Arabidopsis thaliana using Protein Microarrays (2012) Dezfulian MH, Roberto DKA, Popescu SC, Crosby WL ICSB-2012 - The 13th International Conference on Systems Biology, Toronto, Canada 14. Ab initio Assembly, Annotation and Analysis of the Phaseolus var. OAC-REX Genome (2012) Dinatale C, Platts A, Dezfulian MH, Perry G, Pauls KP, Crosby WL Phaseomics-The Genome conference, Guanajuato, Mexico Abstract 15. Computational Analysis of Domain Interactions in Stability of Protein-protein Interactions (2014) Maleki M., Dezfulian MH, Crosby WL, Rueda L. 18th Annual International Conference on Research in Computational Molecular Biology, Pittsburgh, Pennsylvania Poster 16. Computational Analysis of the Stability of SCF Ligases Employing Domain Information (2014) Maleki M.,Rueda L, Dezfulian MH., and Crosby WL, 5th ACM Conf. on Bioinformatics, Computational Biology and Health Informatics (ACMBCB), CA 17. A Computational Domain-based Feature Grouping Approach for Prediction of Stability of SCF Ligases (2015) Maleki, M. Dezfulian, MH and Rueda L, 3rd Interanational Work-conference on Bioinformatics and Biomedical Engineering (IWBBIO), Granada, Spain, 18. Computational modeling of the effect of amino acid substitutions on the formation of Ubiquitin-based complexes (2015) Maleki, M. Dezfulian, MH and Rueda L, 19th Annual International Conference on Research in Computational Molecular Biology, Warsaw, Poland Poster 19. Identification of cognate antigens for clonally expanded T cells in Sjogren's disease (2023) Dezfulian, MH and Elledge SE, Salivary Glands and Exocrine Biology Gordon Research Conference, CA, USA Link 20.Identification of CD4+ T cell antigens in Sjögren's disease.(2023)Dezfulian, MH and Elledge SE, CSHL Meeting: Systems Immunology, USA Talk Link