Harvard:Biophysics 242r/2011
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Course overview
- Graduate level seminar focusing on in-silico design pipelines for nucleic acid- and protein-based molecular machinery and programmable molecular systems. Students are mentored to produce substantial midterm and final group design projects.
- No formal prerequisites. Projects are tailored to each student's strengths and interests.
Example topics for final design project
- Artificial chemotactic swimmers
- Nonequilibrium networks of nano-machines mimicking dynamic instability in the cytoskeleton
- Nucleic acid logic automata responsive to microRNAs in serum
- Self-assembled solar energy harvester based on bio-inorganic nano-antennae for uv-vis
- Systematic debugging of DNA labeling chemistries by atomic-resolution TEM imaging of DNA origami
- Light-controlled transcriptional activation and repression through rational molecular design
- Directed evolution of tissue engineering scaffold nano-materials
- Programmable multistep chemical synthesis by templating on nanostructures
- Ultra-sensitive molecular signal processing for synthetic biology
- Synthetic nanostructure - virus conjugates
- Nano-breadboards for probing electron transport in proteins
- Replication of information in synthetic crystals
- Etc.
Logistics
- Meeting time: 2011 Spring Term, Mondays and Wednesdays, 100 pm — 230 pm, with optional sessions for working on projects from 230 pm to 330 pm, starting on Monday, February 7
- Form teams for midterm projects on Monday, February 7
- Form teams for final projects on Monday, March 21
- First class on Monday, January 24
- Location: CLSB521
- No exams
- Prerequisites: none
- Grading
- 33% Participation
- 33% Midterm project
- 33% Final project
- Harvard course site
- Harvard:Biophysics_242r/2011/Course Development Log
Background Info and previous class projects
Recent changes
List of abbreviations:
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