Jacobs: Difference between revisions

Welcome to the Cell and Molecular Biomechanics Lab at [http://www.columbia.edu Columbia University]! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation.  Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading.  This work has applications in developing new therapies to age-related bone loss and osteoporosis.  We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice.  Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.