User:Christopher Jacobs

Contact Info

• Christopher Jacobs
• Columbia University
• Department of Biomedical Engineering
• 351 Engineering Terrace, Mail Code 8904
• 1210 Amsterdam Avenue
• New York, NY 10027
• Email me through OpenWetWare

I am the director of the Cell and Molecular Biomechanics Lab at Columbia University. I learned about OpenWetWare from Ron Kwon, one of my grad students. Since I was in the midst of a move from Stanford to Columbia at the time, I decided to begin my new lab site here.

Education

• 1994, PhD, Mechanical Engineering, Stanford
• 1989, MS, Mechanical Engineering, Stanford
• 1988, BS, Systems Science and Mathematics, Washington University

Research interests

Molecular mechanisms of cellular mechanosensitivity in bone

Selected Publications

1. Kwon RY, Lew AJ, and Jacobs CR. A microstructurally informed model for the mechanical response of three-dimensional actin networks. Comput Methods Biomech Biomed Engin. 2008 Aug;11(4):407-18. DOI:10.1080/10255840801888686 |
2. Malone AM, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, and Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13325-30. DOI:10.1073/pnas.0700636104 |
3. You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, and Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone. 2008 Jan;42(1):172-9. DOI:10.1016/j.bone.2007.09.047 |
4. Kwon RY and Jacobs CR. Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling. J Biomech. 2007;40(14):3162-8. DOI:10.1016/j.jbiomech.2007.04.003 |
5. Malone AM, Batra NN, Shivaram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, and Jacobs CR. The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol. 2007 May;292(5):C1830-6. DOI:10.1152/ajpcell.00352.2005 |
6. Kim CH, You L, Yellowley CE, and Jacobs CR. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone. 2006 Nov;39(5):1043-1047. DOI:10.1016/j.bone.2006.05.017 |
7. Rubin J, Rubin C, and Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene. 2006 Feb 15;367:1-16. DOI:10.1016/j.gene.2005.10.028 |
8. Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, and Jacobs CR. Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech. 2005 Sep;38(9):1909-17. DOI:10.1016/j.jbiomech.2004.08.009 |
9. Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, and Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. 2004 Nov;22(6):1283-9. DOI:10.1016/j.orthres.2004.04.002 |
10. Malone AM, Batra NN, Shivaram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, and Jacobs CR. The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol. 2007 May;292(5):C1830-6. DOI:10.1152/ajpcell.00352.2005 |

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