Submissions to NCI Screening Program
The group can submit any compounds to the National Cancer Institute's Developmental Therapeutics Program. This involves a number of different assays including the NCI 60 cancer cell lines. Before submitting compounds: 1. Talk to Mat. Compounds ought to be submitted in groups (not one at a time) Note that this sequence needs to be completed each time we send compounds. Hence it's worth sending a few compounds (not one!) at a time. To submit compounds: The NCI site has guidelines for this. We have an account on the system - Username is TheToddLab, password you can get from Mat - use these to login to the system here. Structures submitted will be evaluated by NCI, and they will contact us if they want physical samples. Note the following: "After the DTP selection process is complete, the supplier will receive e-mail notification of a decision and if selected, instructions for mailing the physical sample(s) to the NCI Repository. Suppliers should not send in any samples until instructed. The sample size requirement is 10-15 mg, but for relatively inaccessible natural products, 5 mg is acceptable." |