Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies, M. Spain, J. K.-H. Wong, G. Nagalingam, J. M. Batten, E. Hortle, S. Oehlers, X.-F. Jiang, H. E. Murage, J. T. Orford, P. Crisologo, J. A. Triccas, P. J. Rutledge and M. H. Todd, J. Med. Chem. 2018, 61, in press.
Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands, Y. H. Lau, J. K. Clegg, J. R. Price, R. B. Marquart, M. H. Todd and P. J. Rutledge, Chem. Eur. J. 2017, in press. Paper
The C6H6 NMR Repository: an Integral Solution to Control the Flow of your Data from the Magnet to the Public, L. Patiny, M. Zasso, D. Kostro, A. Bernal, A. M. Castillo, A. Bolaños, M. A. Asencio, N. Pellet, M. H. Todd, N. Schloerer, S. Kuhn, E. Holmes, S. Javor and J. Wist, Mag. Res. Chem., 2017 in press. DOI: 10.1002/mrc.4669
N-Aryl Groups are Ubiquitous in Cross Dehydrogenative Couplings Because They Stabilize Reactive Intermediates, A. S.-K. Tsang, A. S. K. Hashmi, P. Comba, M. Kerscher, B. Chan and M. H. Todd, Chem. Eur. J 2017, 23, 9313–9318. Paper
An Open Source Pharma Roadmap, M. Balasegaram, P. Kolb, J. McKew, J. Menon, P. Olliaro, T. Sablinski, Z. Thomas, M. H. Todd, E. Torreele and J. Wilbanks, PLoS Med. 2017, 14(4): e1002276. Paper Explainer piece in the Guardian.
Recent Advances in Small-molecule Fluorescent Probes for Ion Sensing, J. K.-H. Wong, M. H. Todd and P. J. Rutledge, Molecules 2017, 22, 200. (Invited Contribution to Special Issue on Molecular Imaging Probes). Paper
Selective Displacement of a Scorpionand Triazole Ligand from Metallo-cyclam Complexes Visualised Using NMR Spectroscopy. J. K.-H. Wong, N. Proschogo, M. H. Todd and P. J. Rutledge, Eur. J. Inorg. Chem. 2017, 1075–1086. Highlighted as a Very Important Paper. Paper
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles, A. E. Williamson, P. M. Ylioja, M. N. Robertson, Y. Antonova-Koch, V. Avery, J. B. Baell, H. Batchu, S. Batra, J. N. Burrows, S. Bhattacharyya, F. Calderon, S. A. Charman, J. Clark, B. Crespo, M. Dean, S. L. Debbert, M. Delves, A. S. M. Dennis, F. Deroose, S. Duffy, S. Fletcher, G. Giaever, I. Hallyburton, F.-J. Gamo, M. Gebbia, R. K. Guy, Z. Hungerford, K. Kirk, M. J. Lafuente-Monasterio, A. Lee, S. Meister, C. Nislow, J. P. Overington, G. Papadatos, L. Patiny, J. Pham, S. A. Ralph, A. Ruecker, E. Ryan, C. Southan, K. Srivastava, C. Swain, M. J. Tarnowski, P. Thomson, P. Turner, I. M. Wallace, T. N. C. Wells, K. White, L. White, P. Willis, E. A. Winzeler, S. Wittlin, and M. H. Todd, ACS Cent. Sci. 2016, 2, 687–701. Paper Featured in the Sydney Morning Herald, El Mundo (Spanish language newspaper), IFL Science, Campus Review, ABC TV and Radio, Channel 10 television news, Radio Adelaide and an interview for the 2016 shareholder video for the pharmaceutical company GlaxoSmithKline (collaborators on the project); led to invited lay summary in The Conversation (Sept 14th 2016) and a Reddit Ask Me Anything online Q&A (published in The Winnower: DOI: 10.15200/winn.147558.85439).
A Direct Method for the N-Tetraalkylation of Azamacrocycles, A. J. Counsell, A. T. Jones, M. H. Todd and P. J. Rutledge, Beilstein J. Org. Chem. 2016, 12, 2457-2461. Paper
SCINDR - The SCience INtroDuction Robot that will Connect Open Scientists, C. Smith, M. H. Todd, L. Patiny, C. Swain, C. Southan, A. E. Williamson and A. Clark, Research Ideas and Outcomes 2016, 2:e9995. Paper
Synthesis and Evaluation of 1,8-Disubstituted-cyclam/naphthalimide Conjugates as Probes for Metal Ions, J. K.-H. Wong, S. Ast, M. Yu, R. Flehr, A. J. Counsell, P. Turner, P. Crisologo, M. H. Todd and P. J. Rutledge, ChemistryOpen 2016, 5, 375–385. Paper
Non-toxic Metal-cyclam Complexes, a New Class of Compounds with Potency Against Drug-resistant Mycobacterium tuberculosis, M. Yu, G. Nagalingam, S. Ellis, E. Martinez, V. Sintchenko, M. Spain, P. J. Rutledge, M. H. Todd and J. Triccas, J. Med. Chem. 2016, 59, 5917–5921. Paper.
Efficient Deprotection of F-BODIPY Derivatives: Removal of BF2 using Brønsted Acids, M. Yu, J. K.-H. Wong, C. Tang, P. Turner, M. H. Todd and P. J. Rutledge, Beilstein J. Org. Chem. 2015, 11, 37–41. Paper
Using Click Chemistry to Tune the Properties and the Fluorescence Response Mechanism of Structurally Similar Probes for Metal Ions, S. Ast, S. Kuke, P. J. Rutledge and M. H. Todd, Eur. J. Inorg. Chem. 2015, 58-66. Paper
Experiences with LabTrove, a Researcher-centric ELN, K. A. Badiola, C. Bird, W. S. Brocklesby, J. Casson, R. T. Chapman, S. J. Coles, J. R. Cronshaw, A. Fisher, J. G. Frey, D. Gloria, M. C. Grossel, D. B. Hibbert, L. K. Mapp, B. Matthews, A. Milsted, R. S. Minns, K. T. Mueller, K. Murphy, C. Neylon, T. Parkinson, R. Quinnell, J. S. Robinson, M. N. Robertson, M. Robins, E. Springate, G. Tizzard, M. H. Todd, A. E. Williamson, C. Willoughby, E. Yang and P. M. Ylioja, Chem. Sci. 2015, 6, 1614-1629. Paper
Efficient Synthesis and Anti-tubercular Activity of a Series of Spirocycles: An Exercise in Open Science, K. A. Badiola, D. H. Quan, J. A. Triccas and M. H. Todd, PLOS ONE 2014, 9(12): e111782 Paper
pH-Responsive Quantum Dots (RQDs) that Combine a Fluorescent Nanoparticle with a pH-Sensitive Dye, S. Ast, P. J. Rutledge and M. H. Todd, Phys. Chem. Chem. Phys. 2014, 16, 25255-25257 Paper
Neuroprotective Peptide-Macrocycle Conjugates Reveal Complex Structure-Activity Relationships in their Interactions with Amyloid ß, M. Yu, T. M. Ryan, S. Ellis, A. I. Bush, J. A. Triccas, P. J. Rutledge and M. H. Todd, Metallomics 2014, 6, 1931-1940 Paper
The Properties and Performance of a pH-responsive Functionalised Nanoparticle, S. Ast, P. J. Rutledge and M. H. Todd, Faraday Discuss. 2014, 175, 171-187. Paper Associated discussion: Faraday Discuss. 2014, 175, 215-227. Paper
Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni, I. Meister, K. Ingram-Sieber, N. Cowan, M. H. Todd, M. N. Robertson, C. Meli, M. Patra, G. Gasser and J. Keiser, Antimicrob. Ag. Chemother. 2014, 58, 5466-5472. Paper
Separation of Enantiomers: Synthetic Methods, M. H. Todd, Ed. Wiley-VCH, 2014. Includes:
Review by Richard Kellogg published in Angewandte Chemie described it as "a thoughtfully constructed, and well-written book full of useful information".
Mechanisms of CDC Reactions, A. S.-K. Tsang, S. J. Park and M. H. Todd, in From C–H to C–C Bonds: Cross Dehydrogenative Coupling, C.-J. Li, Ed., 2014, Royal Society of Chemistry, Cambridge. Chapter
Incorporating a Piperidinyl Group in the Fluorophore Extends the Fluorescence Lifetime of Click-derived Cyclam-naphthalimide Conjugates, M. Yu, S. Ast, Q. Yu, A. T. S. Lo, R. Flehr, M. H. Todd and P. J. Rutledge, PLoS ONE 2014, 9(7): e100761 Paper
Open Source Drug Discovery – A Limited Tutorial, M. N. Robertson, P. M. Ylioja, A. E. Williamson, M. Woelfle, M. Robins, K. A. Badiola, P. Willis, P. Olliaro, T. N. C. Wells and M. H. Todd, Parasitology 2014, 141, 148-157 Paper Altmetric Data
In Vitro Metabolic Profile and In Vivo Antischistosomal Activity Studies of (η6-Praziquantel)Cr(CO)3 Derivatives, M. Patra, K. Ingram, A. Leonidova, V. Pierroz, S. Ferrari, M. N. Robertson, M. H. Todd, J. Keiser and G. Gasser, J. Med. Chem. 2013, 56, 9192-9198 Paper
Synthesis of Elongated Cavitands via Click Reactions and their use as Chemosensors, Z. Csok, T. Kegl, Y. Li, R. Skoda-Foldes, L. Kiss, S. Kunsagi-Mate, M. H. Todd and L. Kollar, Tetrahedron 2013, 69, 8186-8190. Paper
Ten Simple Rules for Cultivating Open Science and Collaborative R&D, H. Masum, A. Rao, B. M. Good, M. H. Todd, A. M. Edwards, L. Chan, B. A. Bunin, A. I. Su, Z. Thomas and P. E. Bourne, PLoS Comp. Biol. 2013, 9, e1003244 Paper
Enhancing the Usefulness of Cross Dehydrogenative Coupling Reactions with a Removable Protecting Group, A. S.-K. Tsang, K. Ingram, J. Keiser, B. Hibbert and M. H. Todd, Org. Biomol. Chem. 2013, 11, 4921-4924. Paper
Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity Without Inducing Cytotoxicity, M. Yu, N. H. Lim, S. Ellis, H. Nagase, J. A. Triccas, P. J. Rutledge and M. H. Todd, ChemistryOpen 2013 2, 99-105. Paper
A Fluorescent "Allosteric Scorpionate" Complex Visualizes a Biological Recognition Event, M. Yu, P. J. Rutledge and M. H. Todd, ChemBioChem 2013, 14, 224-229. Paper
The Synaptic Leap: Open Science Combating Disease, P. Parker, B. Schwendimann, K. Thompson and M. H. Todd, in Architecture of Productive Learning Networks, L. Carvalho and P. Goodyear, Eds., 2013, Routledge (ISBN 978-0-415-81655-7)
Reversing the Triazole Topology in a Cyclam-triazole-dye Ligand Gives a 10-fold Brighter Signal Response to Zn(II) in Aqueous Solution, S. Ast, P. J. Rutledge and M. H. Todd, Eur. J. Inorg. Chem. 2012, 5611-5615. Paper
The Outcome of the Oxidations of Unusual Enediamide Motifs is Governed by the Stabilities of the Intermediate Iminium Ions, M. Ahamed, B. Chan and M. H. Todd, PLoS ONE, 2012, 7(10): e47224. Paper
The First Catalytic, Enantioselective Aza-Henry Reaction of an Unactivated Cyclic Imine, N. R. Amarasinghe, P. Turner and M. H. Todd, Adv. Synth. Catal. 2012, 354, 2954-2958. Paper.
Oxidative Arylation of Isochroman, S. J. Park, J. Price and M. H. Todd, J. Org. Chem. 2012, 77, 949-955. Paper
Copper, Nickel and Zinc Cyclam-amino Acid and Cyclam-peptide Complexes may be Synthesized with “Click” Chemistry and are Non-cytotoxic, M. Yu, J. Price, P. Jensen, T. Shelper, C. Lovitt, S. Duffy, L. Windus, V. Avery, P. J. Rutledge and M. H. Todd, Inorg. Chem. 2011, 50, 12823-12835. Paper
Open Science is a Research Accelerator, M. Woelfle, P. Olliaro and M. H. Todd, Nature Chemistry 2011, 3, 745-748. Paper (mentioned on the cover) Discussed here, in more detail here (mirrored on Faculty of 1000 site) and here. Apparently enjoyed by the Chief Executive of BBSRC! Altmetric Data
Resolution of Praziquantel, M. Woelfle, J.-P. Seerden, J. de Gooijer, K. Pouwer, P. Olliaro and M. H. Todd, PLoS Negl. Trop. Dis. 2011, 5(9): e1260. Paper Picked up on the WHO website and evaluated on the F1000 website. A thorough meta-analysis of the project was published.
Polyamide-scorpion Cyclam Lexitropsins Selectively Bind AT-rich DNA Independently of the Nature of the Coordinated Metal, A. T. S. Lo, N. K. Salam, D. E. Hibbs, P. J. Rutledge and M. H. Todd, PLoS One 2011 6(5): e17446. Paper
Chemical Sensors that Incorporate Click-Derived Triazoles, Y. H. Lau, P. J. Rutledge, M. Watkinson and M. H. Todd, Chem. Soc. Rev. 2011 40, 2848-2866. Paper
A DDQ-mediated Oxidative Carbon-carbon Bond Forming Reaction Proceeds via an Isolable Iminium Ion A. S.-K. Tsang, P. Jensen, J. M. Hook, A. S. K. Hashmi and M. H. Todd, Pure Appl. Chem. 2011, 83, 655-665. Paper
A Click Fluorophore Sensor that can Distinguish CuII and HgII via Selective Anion-Induced Demetallation, Y. H. Lau, J. Price, M. H. Todd and P. J. Rutledge, Chem. Eur. J. 2011, 17, 2850-2858. Paper Featured in Chemistry Views and selected as the journal frontispiece.
Gold Catalysis: Reactions of Organogold Compounds with Electrophiles, A. S. K. Hashmi, T. D. Ramamurthi, M. H. Todd, A. S.-K. Tsang and K. Graf, Aust, J. Chem. 2010, 63, 1619-1626. Paper
Aza-Henry Reactions of 3,4-Dihydroisoquinoline, M. Ahamed, T. Thirukkumaran, W. Y. Leung, P. Jensen, J. Schroers and M. H. Todd, Eur. J. Org. Chem. 2010, 5980-5988. Paper
Catalytic, Asymmetric Additions of Carbon-centered Nucleophiles to Nitrogen-containing Heterocycles, M. Ahamed and M. H. Todd, Eur. J. Org. Chem. 2010, 5935-5942. Paper
Cyclam-based "Clickates": Homogeneous and Heterogeneous Fluorescent Sensors for Zn(II), E. Tamanini, K. Flavin, M. Motevalli, S. Piperno, L. A. Gheber, M. H. Todd and M. Watkinson, Inorg. Chem. 2010, 49, 3789-3800. Paper
Can We Measure Catalyst Efficiency in Asymmetric Chemical Reactions? A Theoretical Approach, S. El-Fayyoumy, M. H. Todd and C. J. Richards, Beilstein J. Org. Chem. 2009, 5, No. 67. Paper The Jones group at the University of Sheffield have set up an ACES calculator.
Kernel for Tropical Disease Initiative, L. Orti, R. J. Carbajo, U. Pieper, N. Eswar, S. M. Maurer, A. K. Rai, G. Taylor, M. H. Todd, A. Pineda-Lucena, A. Sali and M. A. Marti-Renom, Nature Biotech. 2009, 27, 320-321. Paper or Link to pdf
Chemotherapeutic Development Strategies for Schistosomiasis, C. R. Caffrey, D. L. Williams, M. H. Todd, D. L. Nelson, J. Keiser and J. Utzinger, in Drug Discovery in Infectious Diseases: from Molecular Targets to Drug Candidates, P. M. Selzer, Ed., 2009, Wiley-VCH, Weinheim. Chapter
Responsive Metal Complexes: A Click-based "Allosteric Scorpionate" Complex Permits the Detection of a Biological Recognition Events by EPR/ENDOR Spectroscopy, E. Tamanini, S. E. J. Rigby, M. Motevalli, M. H. Todd and M. Watkinson, Chem. Eur. J. 2009, 15, 3720-3728. Paper
A Kernel for Open Source Drug Discovery in Tropical Diseases, L. Orti, R. J. Carbajo, U. Pieper, N. Eswar, S. M. Maurer, A. K. Rai, G. Taylor, M. H. Todd, A. Pineda-Lucena, A. Sali and M. A. Marti-Renom, PLoS Negl. Trop. Dis. 2009, 3(4): e418. Paper
Facile Synthesis of Vicinal Diamines via Oxidation of N-phenyltetrahydroisoquinolines with DDQ, A.-S. K. Tsang and M. H. Todd, Tetrahedron Lett. 2009, 50, 1199-1202. Paper
Synthesis and DNA Binding Ability of Cyclam-amino Acid Conjugates, A. V. Ramana, M. Watkinson and M. H. Todd, Bioorg. Med. Chem. Lett. 2008, 18, 3007-3010. Paper
Effective Methods for the Biotinylation of Azamacrocycles, S. Krivickas, E. Tamanini, M. H. Todd and M. Watkinson, J. Org. Chem. 2007, 72, 8280-8289. Paper
Is Actin the Praziquantel Receptor?, A. R. Troiani, L. Pica-Mattoccia, C. Valle, D. Cioli, G. Mignogna, F. Ronketti and M. H. Todd, Int. J. Antimicrob. Ag. 2007, 30, 280-281. Paper
Praziquantel Analogues. I. Modification of the Aromatic Ring, F. E. Ronketti, A. V. Ramana, X. Chao-Ming, L. Pica-Mattoccia, D. Cioli and M. H. Todd, Bioorg. Med. Chem. Lett. 2007, 17, 4154-4157. Paper
Open Access and Open Source in Chemistry, M. H. Todd, Chem. Central J. 2007, 1:3. Paper
The Effects of Drugs, Ions and Poly-L-lysine on the Excretory System of Schistosoma mansoni, J. R. Kusel, F. Oliveira, M. H. Todd, F. Ronketti, S. Lima, A. C.- de Mattos, K. Teixeira, P. M. Z. Coelho, J. A. Thornhill and F. Ribeiro, Mem. Inst. Oswaldo Cruz. 2006, 101 (Suppl 1), 293-298. Paper
Improved Synthesis of the Valuable Peptidomimetic Intermediate 3-Azido-4-hydroxy Cyclopentanoic Acid, E. Tamanini, M. Watkinson and M. H. Todd, Tetrahedron Asymmetry 2006, 17, 2235-2239. Paper
Open Source Research – the Power of “Us”, T. B. Kepler, M. A. Marti-Renom, S. M. Maurer, A. K. Rai, G. Taylor and M. H. Todd, Aust. J. Chem. 2006, 59, 291-294. Paper
Solid Phase Synthesis of Praziquantel, S. El-Fayoummy, W. Mansour and M. H. Todd, Tetrahedron Lett. 2006, 47, 1287-1290. Paper
(R)-4-Hydroxymethyl-2-ferrocenyloxazoline, M. H. Todd, S. El-Fayyoumy, M. E. Motevalli and C. J. Richards, Acta Cryst. E. 2006, E62, m719-m720. Paper
Design and Synthesis of New Tetrazolyl- and Carboxy-biphenylylmethyl Quinazoline Derivatives as Angiotensin II AT1 Receptor Antagonists, M. A. H. Ismail, S. Barker, D. A. Abou El Ella, K. A. M. Abouzid and R. A. Toubar and M. H. Todd, J. Med. Chem. 2006, 49, 1526-1535. Paper
Computer-Aided Organic Synthesis, M. H. Todd, Chem. Soc. Rev. 2005, 34, 247-266. Paper
Drugs for the Control of Parasitic Diseases: Current Status and Development. Schistosomiasis, A. Fenwick, L. Savioli, D. Engels, R. Bergquist and M. H. Todd, Trends Parasitol. 2003, 19, 509-515. Paper
Asymmetric Autocatalysis: Product Recruitment for the Increase in the Chiral Environment (PRICE), M. H. Todd, Chem. Soc. Rev. 2002, 31, 211-222. Paper
Use of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in the Tagging of a Combinatorial Library, M. H. Todd and C. Abell, Analyst 2002, 127, 1399-1406. Paper
Amino Acid-Derived Heterocycles: Lewis Acid-Catalyzed and Radical Cyclizations from Peptide Acetals, M. H. Todd, C. O. Ndubaku and P. A. Bartlett, J. Org. Chem. 2002, 67, 3985-3988. Paper
Novel Chemical Tagging Method for Combinatorial Synthesis Utilizing Suzuki Chemistry and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, M. H. Todd and C. Abell, J. Comb. Chem. 2001, 3, 319-327. Paper
The Attachment and Cleavage of Phenols from Solid Supports, and their Single-bead Mass Spectral Analysis, M. H. Todd and C. Abell, Tetrahedron Lett. 2000, 41, 8183-8187. Paper
Palladium-catalyzed Carbon-carbon Bond Formation on Solid Support, M. H. Todd and C. Abell, in Solid Phase Synthesis, Burgess, K. (Ed.), Wiley-Interscience (New York), 2000, 25-79.
A Novel Safety-Catch Linker for the Solid Phase Synthesis of Amides and Esters, M. H. Todd, S. F. Oliver and C. Abell, Org. Lett. 1999, 1, 1149-1151. Paper
Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids, M. H. Todd, S. Balasubramanian and C. Abell, Tetrahedron Lett. 1997, 38, 6781-6784. Paper