20.20:Advanced topics

<html> <style>#en2020 a {color:black;}</style> </html>

Biological Engineering Design
Advanced topics reading schedule
Wednesdays for 1 hour during 2-5 studio block
26-152

TOPIC	DATE	Discussion leader(s)	Discussion paper(s)	Related paper(s) to enjoy
A Voyage To Lilliput: How a small number of AA substitution change activity of a protein	Wed Feb 6	Natalie Kuldell and Drew Endy	Bushman FD, Ptashne M. Turning lambda Cro into a transcriptional activator Cell. 1988 Jul 15;54(2):191-7. PMID 2968842
Natural systems have modular components	Wed Feb 13	Ptashne “Two ‘What if” experiments” [1] Brent “Build Artificial” [2] Brent/Ptashne “LexA/Gal4” [3]
You can build devices from natural modules	Wed Feb 20	Collin’s toggle Elowitz’ repressilator
Natural systems are noisy	Wed Feb 27	Hysteresis and noise
	Wed Mar 5	NK and DE OoT
Natural systems can be intentionally changed to be useful	Wed Mar 12	Protein induction systems
Natural systems can offer improved chassis	Wed Mar 19	Metabolic engineering Minimal genomes Artificial cells [4]
Spring Break Mar 24-28			No class all week
Computational design of unnatural systems	Wed Apr 2	Dwyer, Looger, Hellinga “Computational design of active enzyme” Some ex of directed evolution Building Logic gates
Expanding Nature’s Genetic Programming Language	Wed Apr 9	Chin Schultz “expanded genetic code” [5] BK Davis commentary [6] Recoli Tx’l of polymers [7]
Programming artificial life	Wed Apr 16	2 genomes 1 cell 1 cell to new cell
Populations of cells communicate	Apr 23
Populations of cells make patterns	Wed Apr 30
Presentations 1	Wed Apr 30
Presentations 2	Wed May 7
Presentations 3	Wed May 14


Home	Lecture schedule	Studio schedule	Expectations

Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7
Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14

Navigation menu