- Oscillators are a fundamental building block in traditional engineering applications (i.e. computers, radio, clocks) , as well as a recurrent motif in many biological systems (i.e.circadian rhythm, menstrual cycle).
- We intend to build a generic and modular synthetic biological oscillator that can become a fundamental building block in future synthetic biological applications.
- Previous oscillators have been attempted (such as the Repressilator by Elowitz and Leibler in 2000) but they often share the following problems:
- Noisy and Unstable (due to stochastic molecular events at the single cell level, cell-cell variability, cell division)
- Damping (i.e.with cell-cell asynchrony)
- Inflexible (i.e. lack of control over amplitude and frequency)
- No easy connectivity (hard to integrate into larger systems)
- Based on these past limitations, we have defined the specifications for our oscillator.
||Oscillations should be stable for greater then 10 cycles. Stable in amplitude, frequency and output profile.
||Output signal should have a high signal to noise ratio.
||Amplitude and frequency should be controllable.
|| Large enough to have an easy detection.
| Frequency Range
||From a period of the order of the hour to several hours.
||The oscillator should be easily integrated into other more complicated systems. Modular and generic output.
|| Output signal
| Frequency tuning
| Amplitude tuning
- In electronic, the stability of the oscillations is a key factor, but the profile of the ouput signal is also an important property of an oscillator. There is an important variety of output profiles used in electronic (harmonic, square-wave, triangle-wave). Sometimes, for a given application a given profile is required. read more>>
- Due to biological variability, getting a stable behavior might be challenging.
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