Postdoctoral Associate in the Department of Medicine at Washington University
The Hughes Lab is located in the Division of Pulmonary and Critical Care Medicine at Washington University. We are seeking talented applicants for a postdoctoral position studying the effects of systemic inflammation on skeletal muscle.
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in the United States, and its extra-pulmonary manifestations are a shockingly under-studied contributor to morbidity and mortality. Our lab has recently published (Terry et al. (2018) eLife) the definitive resource of gene expression in skeletal muscle (http://muscledb.org). With these data as a foundation, we are now using functional genomics approaches to study how skeletal muscle reacts to pulmonary disease. We have established a pre-clinical mouse model that recapitulates muscle atrophy due to COPD. Our current projects focus on identifying the cells, genes, and signaling pathways that govern reciprocal interactions between the lungs and muscle. Our long-term goal is to manipulate skeletal muscle for the betterment of human COPD patients. These projects will require the effective use of pre-clinical mouse models, RNAseq, single-cell RNAseq, muscle physiology and histology, and the analysis of human clinical samples.
Salary will be commensurate with qualification and experience. The strongest candidates will have experience in some combination of skeletal muscle biology, bioinformatics, and mouse genetics. Candidates should apply by emailing their cover letter, curriculum vitae, and the names of three references to Dr. Michael Hughes: firstname.lastname@example.org.
• PhD or equivalent in Biomedical sciences
• Comfort and experience working with laboratory mice
Knowledge, Skills, and Abilities:
• Bioinformatics, R, SQL, Python, etc.
• Fluency in molecular biology and mouse genetics
• Ability to work well in a team of scientists from diverse backgrounds