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Our laboratory is interested in the function and mechanism of tissue-specific gene expression. This leads us to study many different biological phenomena, including circadian clock outputs, specialization of skeletal muscle, and pathological changes in pulmonary disease. We study the specialization of both mRNA and small ncRNA expression, as well as the functional consequences of their manipulation. We use a combination of functional genomics, bioinformatics, and molecular biology approaches.

Hughes Lab
Pulmonary and Critical Care Medicine
Washington University School of Medicine