From OpenWetWare
Jump to navigationJump to search

<html> <head>

  1. column-one { display:none; width:0px;}

.container{background-color: #f5f5f5; margin-top:50px} .OWWNBcpCurrentDateFilled {display: none;}

  1. content {width: 0px; margin: 0 auto auto 0; padding: 1em 1em 1em 1em; align: center;}
  2. column-content {width: 0px; float: left; margin: 0 0 0 0;padding: 0;}

.firstHeading {display:none; width:0px;}

  1. globalWrapper{width:1280px; margin:auto}

body {background: #F0F0F0 !important;}

  1. column-one {display:none; width:0px;background-color: #f0f0f0;}
  2. content{border:none;margin: 0 0 0 0; padding: 1em 1em 1em 1em; position: center; width: 800px;background-color: #f0f0f0; }

.container{ width: 800px; margin: auto; background-color: #f0f0f0; text-align:justify; font-family: helvetica, arial, sans-serif; color:#f0f0f0; margin-top:25px; }

  1. bodyContent{ width: 1267px; align: center; background-color: #f0f0f0;}
  2. column-content{width: 1280px;background-color: #f0f0f0;}

.firstHeading { display:none;width:0px;background-color: #f0f0f0;}

  1. header{position: center; width: 800px;background-color: #f0f0f0;}
  2. footer{position: center; width:1280px;}

</head> </html>

<html><center><a href=''><img src= width=800px></a></center></html>

Home              Mission              Process              Designs              Results              Resources              Team

Results Overview

We have accomplished the following:

  • With our original rectangular box design, we have developed a system that can trap, hold, and release nanocargo.
  • We have opened Han’s sphere in preparation for future nanocargo encapsulation.
  • We are now one step closer to achieving simpler signal amplification, more complex logic gates, and submarine-like drug delivery.

Box Container

Figure 1. A box with enclosed gold under a transmission electron microscope.
  • We designed and folded two robust origami structures: the lid and the barrel. These two structures are the components of our box.
  • We demonstrated that we can close and open the box with high efficiency.
  • We demonstrated that we can attach AuNP cargo to our lids and/or our barrels and then close the box, placing the AuNP cargo within the box.
  • We demonstrated that we can photocleave the AuNP cargo off of our lids, solubilizing the cargo.

Continue reading...

See also: Rectangular Box Design, Rectangular Box Methods

Spherical Container

Figure 2. Open spheres under an atomic force microscope.

With our sphere design, we were able to:

  • Fold and characterize through atomic force microscopy (AFM) the original Han et al. sphere, which we call the "closed" sphere.
  • Fold and characterize through AFM our "open" sphere in which we removed all equator staple strands.
  • Test various lock mechanisms to transition between the closed and open states of the sphere.
  • Analyze the scaffold-staple-lock system to find out why certain lock designs were unsuccessful at closing the sphere.

Continue reading...

See also: Sphere Design, Sphere Methods


Figure 3. Evidence of DNA conjugation to gold nanoparticles
  • We synthesized 5nm gold particles and conjugated DNA to their surfaces
  • We conjugated DNA to commercially available 5 nm gold nanoparticles
  • We integrated AuNP-DNA conjugates into our rectangular box design

Continue reading...
See also: Cargo Design


  • We demonstrated photo-cleavage of strands with internal photo-cleavable spacers
  • We outlined a process for the use of photo-cleavable spacers as a means to open our containers and solubilize our cargo

Continue reading...
See also: Cargo Design

Tools and Parts