Xulab:Publications

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Peer-reviewed journal articles (since 2004)

  • Ronald Xu*, "Multifunctional microbubbles and nanobubbles for photoacoustic imaging," Contrast Media Mol Imaging. Vol. 6, no. 5: 401-11 (2011).Read
  • Ronald Xu*, Jeff Xu, Tao Zuo, Rulong Shen, Tim Huang, and Michael Tweedle. Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy. Journal of Biomedical Optics. Vol. 16, no. 2: 020507 (2011). Read
  • Chulhong Kim, Ruogu Qin, Jeff Xu, Lihong Wang *, and Ronald Xu*. Ultrasound and photoacoustic dual-modal imaging of thick biological tissue with microbubble enhancement. Journal of Biomedical Optics. Vol. 15, no. 1: 010510 (2010). Read
  • Hamid El-Dahdah, Bei Wang, Guanglong He, Ronald X. Xu*. An Automatic Occlusion Device for Remote Control of Tumor Tissue Ischemia. Technology in Cancer Research and Treatment. Vol. 1, no. 9: 71-76 (2010).
  • Jeff Xu, Jiwei Huang, Ruogu Qin, Stephen Povoski, Edward Martin, Ronald Xu*. Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging. Biomaterials. Vol. 7, no. 31: 1716-1722 (2010). Read
  • Jiwei Huang, Jeff S. Xu, Ronald X. Xu*. Heat-sensitive microbubbles for intraoperative assessment of cancerablation margins. Biomaterials. Vol. 6, no. 31: 1278-1286 (2010). Read
  • Leilei Zhang, Jeff S. Xu, Virginia M. Sanders, Alan D. Letson, Cynthia J. Roberts, and Ronald X. Xu*, Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy, Journal of Biomedical Optics. Vol. 15, no. 3, p 030515. (2010). Read
  • Peng Zou, Stephen P. Povoski,*, Nathan C. Hall, Michelle M. Carlton, George H. Hinkle, Ronald X. Xu, Cathy M. Mojzisik, Morgan A. Johnson, Michael V. Knopp, Edward W. Martin, and Duxin Sun. 2010. 124I-HuCC49deltaCH2 for TAG-72 antigen-directed positron emission tomography (PET) imaging of LS174T colon adenocarcinoma tumor implants in xenograft mice: Preliminary results. World Journal of Surgical Oncology. Vol 8, p 65 (2010).Read
  • Ronald X. Xu, Kun Huang, Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Urmila S. Gnyawali, Gayle Gordillo, Surya C. Gnyawali, and Chandan K. Sen*. Dual-mode imaging of cutaneous tissue oxygenation and tissue vascular thermal reactivity. Journal of Visualized Experiments. doi: 10.3791/2095 (2010).Read
  • Ronald Xu*, Stephen Povoski, Edward Martin. Targeted delivery of microbubbles and nanobubbles for image-guided thermal ablation therapy of tumors. Expert Rev Med Devices. 7(3): p303-6. (2010). Read
  • Peng Zou, Songbo Xu, Stephen P. Povoski, Anna Wang, Morgan A. Johnson, Edward W. Martin, Jr., Vish Subramaniam, Ronald Xu*, and Duxin Sun*. Near-Infrared Fluo-rescence Labeled Anti-TAG-72 Monoclonal Antibodies for Tumor Imaging in Colorectal Cancer Xenograft Mice. Molecular Pharmaceutics. Vol. 6, no. 2: 428-440. (2009). Read
  • Ronald Xu*, Jiwei Huang, Jeff Xu, Duxin Sun, George Hinkle, Edward Martin and S. Povoski. Fabrication of indocyanine green encapsulated biodegradable micro－bubbles for structural and functional imaging of cancer. Journal of Biomedical Optics. Vol. 14, no. 3: 034020(2009). Read
  • Stephen P. Povoski*, Rafael E. Jimenez, Wenle P. Wang, Ronald X. Xu. Standardized and reproducible methodology for the comprehensive and systematic assessment of surgical resection margins during breast-conserving surgery for invasive breast cancer. BMC Cancer. Vol. 9, no. 1: 254. (2009). Read
  • Bei Wang, Stephen P. Povoski, Xianhua Cao, Duxin Sun, and Ronald X. Xu*. Dynamic schema for near infrared detection of pressure-induced changes in solid tumors. Applied Optics. Vol. 47, no. 16: 3053-3063. (2008). Read
  • Ronald X. Xu*, Joseph Ewing, Hamid El-Dhadah, Bei Wang, Stephen P. Povoski. Design and benchtop validation of a handheld integrated dynamic breast imaging system for noninvasive characterization of suspicious breast lesions. Technology in Cancer Research and Treatment. Vol. 6, no. 7: 471-482. (2008). Read
  • Ronald Xu*, Emanuel Sachs. Rapid Thermal Cycling with Low Thermal Inertia Tools. Polymer Engineering & Science. Vol. 2, no. 49: 305-316. (2008).
  • Ronald X. Xu* and Stephen P. Povoski. Optical imaging and spectroscopy for cancer. Expert Rev Med Devices. Vol. 4, no. 1. (January): 83-95. (2007). Read
  • Ronald X. Xu*, Bo Qiang, Jimmy J. Mao, and Stephen P. Povoski. Development of a handheld near infrared imager for dynamic characterization of in vivo biological tissue systems. Applied Optics. Vol. 46, no. 30: 7442-7451. (2007). Read
  • Ronald X. Xu*, Doung Young, Jimmy Mao, Stephen P. Povoski. A prospective pilot clinical trial evaluating the utility of a dynamic near infrared imaging device for characterizing suspicious breast lesions. Breast Cancer Research. Vol. 9: R88. (2007). Read
  • Xuefeng Cheng, Jimmy .M. Mao, Xiaorong Xu, Mohamed Elmandjra, Robin Bush, Linda Christenson, Bill OKeefe, and John Bry. Post-occlusive reactive hyperemia in patients with peripheral vascular disease. Clinical hemorheology and microcirculation. Vol. 1, no. 31: 11-21. (2004).

    Book chapters

    Ronald Xu. Chapter 17: Selected topics in biomedical engineering. In Intelligent Energy Field Manufacturing. Edited by Wenwu Zhang. Boca Raton, FL: CRC Press (2010).

    Published patents

  • Ronald Xu, Cynthia Roberts, Leilei Zhang, “Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders”. US utility patent filed January 10, 2011, published May 5, 2011. Patent No: 0104069.
  • Ronald Xu, Cynthia Roberts, Leilei Zhang, “Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders”. International patent filed December 29, 2010, published May 5, 2011. Patent No: WO2011/053803.
  • Chandan Sen, Ronald Xu, “Wound goggles”. European patent filed October 26, 2010, published May 11th, 2011. Patent No: EP2319414.
  • Chandan Sen, Ronald Xu, “Wound goggles”. US utility patent filed January 12, 2010, published May 6, 2010. Patent No: 0113940.
  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam, Claudia Turro, “Fluorescence Detection System”. US utility patent filed January 12, 2009, published September 17, 2009. Patent No: 0234227.
  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam, Claudia Turro, “Fluorescence Detection System”. International patent filed January 12, 2009, published July 2009. Patent No: WO2009/089543.

    Conference papers

  • Leilei Zhang, Jeff Xu, Jiwei Huang, Cynthia Roberts, Ronald Xu*. 2010. Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration. In: Proc. SPIE: 7550-61. [Peer Reviewed]
  • R. Qin, J. Xu, R. Xu*, C. Kim, and L. Wang*. 2010. Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging. In: Proc. SPIE: 7567-20. [Peer Reviewed]
  • R. Xu*, J.S. Xu, J. Huang, M.F. Tweedle, C. Schmidt, S.P. Povoski, and E.W. Martin. 2010. Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins. In: Proc. SPIE.: 7551-28. [Peer Reviewed]
  • Ronald X. Xu*, Jeff Xu, Ruogu Qin, Jiwei Huang. 2010. Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging. In: Proc. SPIE.: 7567-19. [Peer Reviewed]
  • Ruogu Qin, Jiwei Huang, Jeff Xu, Surya Gnyawali, Chandan Sen, Kun Huang, Ronald Xu*. 2010. Dual-modal quantitative imaging of wound tissue oxygenation and perfusion. In: Proc. SPIE: 7557-16. [Peer Reviewed]
  • Nasser Kashou*, Ronald Xu, Cynthia Roberts, Larwence Leguire. 2007. Using FMRI and FNIRS for localization and monitoring of visual cortex activities. In: 29th International Conference of the IEEE Engineering in Medicine and Biology Society: IEEE EMBS [Peer Reviewed]
  • R. Xu* and A. Rana. 2006. Dynamic Near Infrared Imaging with Ultrasound Guidance (dNIRUS): Analytical Model and Benchtop Validation on Multi-layer Tissue Simulating Phantoms. In: Proc. SPIE, Vol. 6086: 353-364. [Peer Reviewed]
  • R. Xu*, B. Qiang and C. Roberts. 2006. Retinal Tissue Oxygen Imaging by Near Infrared Lightand White Light Interferometry. In: Proc. SPIE, Vol. 6138: 363-371. [Peer Reviewed]
  • SPIE: 44-53. [Peer Reviewed]
  • B. Qiang, A. Rana, and R. Xu*. 2005. Reconstruction of tissue heterogeneity by near infraredimaging: a novel algorithm and benchtop validation. In: Conf Proc IEEE Eng Med Biol Soc, Vol. 3: 3137-3140. [Peer Reviewed]
  • R. Xu*, B. Qiang, and J. Mao. 2005. Near infrared imaging of tissue heterogeneity: probe designand sensitivity analysis. In: Conf Proc IEEE Eng Med Biol Soc, Vol. 1: 278-281. [Peer Reviewed]
  • R. Xu*, B. Qiang, J. Olsen, S. Povoski, L. Yee, and J. Mao. 2005. Localization and functionalparameter reconstruction of suspicious breast lesions by near infrared/ultrasound dualmodal imaging. In: Conf Proc IEEE Eng Med Biol Soc, Vol. 5: 4473-4476. [Peer Reviewed]
  • R. Xu*, R., B. Qiang, J. Liu. 2005. Ultrasound Guided Near Infrared Spectroscopy for BrainFunctional Study: Feasibility Analysis and Preliminary Work. In: Proc. SPIE, Vol. 5686: 464-472. [Peer Reviewed]

    Abstracts

  • Ronald Xu, Multifunctional microparticles and nanoparticles for breast cancer imaging and image-guided therapy. Department of Defense BCRP Era of Hope Meeting. Orlando, FA. (August 3, 2011) [Peer Reviewed]
  • Ronald Xu, Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins. Department of Defense BCRP Era of Hope Meeting. Orlando, FL. (August 3, 2010) [Peer Reviewed]
  • L. Zhang, J. Xu, A. Letson, C. Roberts, R. Xu*. 2010. Targeted delivery of multifunctional microbubbles for anti-VEGF therapy of age-related macular degeneration. ARVO 2010 Annual Meeting. Fort Lauderdale, FL, USA: The Association for Research in Vision and Ophthalmology. (May 2010) [Peer Reviewed]
  • Feng Wang*, Robert Lee, Ronald Xu. 2010. RF Ablation: A Numerical Model of Perfused Porcine Kidneys. URSI 2010 [Peer Reviewed]
  • J. Huang, J. Xu, R. Xu, S. Povoski, and E. Martin. 2010. Microfabrication of heat-sensitive microbubbles for ablation margin assessment. Journal of Endourology. Vol. 6, no. 23: p1055. [Peer Reviewed] 4. Jeff Xu, Jiwei Huang, Ruogu Qin, Michael Tweedle, Ronald Xu*. 2010. Gold Nanoparticle Assisted Light Activation of Microbubbles for Photothermal Therapy. Photonics West 2010: 7551-32. [Peer Reviewed]
  • Leilei Zhang, Jeff Xu, Ronald Xu, Cynthia Roberts. 2010. Targeted Delivery of Multifunctional Microbubbles for Anti-VEGF Therapy of NeovascularAge-related Macular Degeneration [Abstract]. ARVO 2010 [Peer Reviewed]
  • Ronald Xu. 2010. Innovations in Wound Imaging. Advances in Wound Care and HBO Update 2010 [Editor Reviewed]
  • Ronald Xu. 2010. Multi-Modal Wound Imaging: Prospects of the Future. Heal Ohio2009…Showcasing Emerging Wound Care Technologies and Treatments [Editor Reviewed]
  • Jeff S. Xu, Ronald X. Xu*, Edward W. Martin, Jr., Stephen P. Povosoki, George H. Hinkle, Jeff Schlom. 2009. Synthesizing multifunctional nanobubbles for cancer targeting and multimodal imaging. Biomedical Engineering Society 2009 Annual Fall Meeting [Peer Reviewed]
  • Jiwei Huang, Jeff Xu, Ronald Xu*. 2009. Development of heat-sensitive microbubbles for intraoperative assessment of cancer ablation margin. Biomedical Engineering Society 2009 Annual Fall Meeting [Peer Reviewed]
  • R.X. Xu*, F. Wang, N. Theyyunni, R. Lee, and V.R. Patel. 2009. Numerical simulation of radiofrequency ablation process for intraoperative assessment of tissue temperature and ablation margin. The Journal of Urology. Vol. 4, no. 181: p158. [Peer Reviewed]
  • Ronald X. Xu*, Jeff S. Xu, Jiwei Huang, Duxin Sun, Michelle Carlton, Stephen P. Povoski, Michael V. Knopp, Edward W. Martin, Jr. 2009. Multimodal intraoperative imaging of cancer. Biomedical Engineering Society 2009 Annual Fall Meeting. [Peer Reviewed]
  • Ronald Xu. 2009. Multimodal imaging for wound assessment and healing. Mathematical Biosciences Institute Wound Healing Workshop. Columbus, OH, USA [Editor Reviewed]
  • Ronald Xu, Jeff Xu, Jiwei Huang, Surya Gnyawali, Kun Huang, Gayle Gordillo, Chandan K. Sen*. 2009. Multi-modal quantitative imaging of wound tissue oxygenation and perfusion. Symposium on Advanced Wound Care 2009 [Peer Reviewed]
  • Ruogu Qin, Jeff Xu, Ronald Xu*, Chulhong Kim2, Lihong V. Wang*. 2009. Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging. Biomedical Engineering Society 2009 Annual Fall Meeting. [Peer Reviewed]
  • Jeff Xu, Jiwei Huang, Joseph Ewing, Joseph Agoston, Thomas Shives, Surya Gnyawali,Sabyasachi Biswas, Chandan K. Sen, Kun Huang, Ronald Xu*. 2008. Development of a Multimodal Image System for Noninvasive Assessment of Tissue Vascularization and Perfusion in Cutaneous Wounds. Biomedical Engineering Society 2008 Annual Fall Meeting. St. Louis, MO. [Peer Reviewed]
  • Joseph Ewing, Hamid El-Dah Dah, Bei Wang, Jeff Xu, Stephen Povoski, Ronald Xu*. 2008. Multimodal dynamic imaging of breast cancer. Biomedical Engineering Society 2008 Annual Fall Meeting. St. Louis, MO. [Peer Reviewed]
  • Ronald Xu*, Jeff Xu, Jiwei Huang, Peng Zou, Duxin Sun, Stephen Povoski, Edward Martin. 2008. Multimodal, intraoperative cancer imaging with microbubbles and antibody-fluorophore conjugates. Biomedical Engineering Society 2008 Annual Fall Meeting. St. Louis, MO.[Peer Reviewed]
  • R. Xu*, J. Xu, J. Ewing, B. Wang, D. Sun, S. Povoski, and E. Martin. 2008. Development of indocyanine green encapsulated microbubbles for dynamic imaging of breast cancer. Congressionally Directed Medical Research Programs Era of Hope 2008 Meeting [Peer Reviewed]
  • Bei Wang, Shaotang Zhou,Guanglong He, Ronald Xu*. 2007. Development of a remote vessel occluder for reversible blood flow occlusion on animal models. Biomedical Engineering Society 2007 Annual Fall Meeting. Los Angeles, CA. [Peer Reviewed]
  • Hamid Dahdah, Bei Wang, Ronald Xu*. 2007. Isolation of tissue mechanical and physiologic properties in dynamic near infrared imaging. Biomedical Engineering Society 2007 Annual Fall Meeting. Los Angeles, CA. [Peer Reviewed]
  • Nasser H. Kashou, Bei Wang, Hamid Dahdah, Cynthia J. Roberts, Lawrence E. Leguire, Ronald X. Xu*. 2007. Design of a near infrared sensor head for non-invasive detection of visual cortex activities. Biomedical Engineering Society 2007 Annual Fall Meeting. Los Angeles, CA. [Peer Reviewed]
  • Bo Qiang, Xuehai Zhu, Xianhua Cao, Guanglong He, Duxin Sun, Ronald Xu*. 2006. Development of a Multi-modal Sensor for in vivo Monitoring of Tumor Oxygen Dynamics. Joint 31st International Conference on Infrared and Millimeter Waves and 14th International Conference on Terahertz Electronics. Shanghai, China: IEEE. (August) [Peer Reviewed]
  • Ronald Xu*, Bo Qiang, Duxin Sun, Xianhua Cao, Guanglong He, Xuehai Zhu. 2006. Monitoring Oxygen Dynamics During Reversible Ischemia on Cancer Xenograft Models. Joint 31st International Conference on Infrared and Millimeter Waves and 14th International Conference on Terahertz Electronics. Shanghai, China: IEEE. (August) [Peer Reviewed]
  • Ronald Xu*, Abdul Rana, Bo Qiang, Jun Liu, Robert Lee, Cynthia Roberts. 2006. Multi-modality Imaging Platform to Characterize Mechanical and Physiological Characteristics of Ocular Tissue. SPIE Great Lakes Photonics Symposium. Dayton, OH. (June) [Peer Reviewed]
  • Ronald Xu*, Nasser Kashou, Bo Qiang, Lawrence Leguire, Cynthia Roberts. 2006. Non-invasive, Real Time Monitoring of Cortical and Retina Tissue Physiology During Visual Stimulation. ARVO 2006 annual meeting. Fort Lauderdale, FL, USA: The Association for Research in Vision and Ophthalmology. (May) [Peer Reviewed]
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