User:Torsten Waldminghaus

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Me after being productive

Hi, my name is Torsten Waldminghaus, and I'm PI of the Waldminghaus Lab. I was let to OpenWetWare by google years back, searching for certain protocols. I benefit a lot from people sharing their protocols on the internet and thought it might be a good idea to also let the world participate on my wisdom and experince. If you still want to you can email me through OpenWetWare. Below I'll describe a bit more about myself and the stuff I'm interested in.


  • 2007-2011: Postdoc at the Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo (Norway) in the lab of Kirsten Skarstad
  • 2004-2007: PhD at the Ruhr-University Bochum (Germany) PhD-thesis: ‘RNA-thermometers in bacteria’ in the lab of Franz Narberhaus
  • 2002-2004: Studies in bioinformatics at the University of applied science Berlin (Germany) Master-thesis: ‘In silico analysis and selection of RNA secondary structures’ at the Max Planck Institute for Infection Biology under supervision of Volker Patzel
  • 1999-2002: Studies in biology at the Ernst-Moritz-Arndt-University Greifswald (Germany) Diploma-thesis: ‘Investigations on the expression of clpX in Bacillus subtilis’ at the Division for Microbial Physiology and Molecular Biology in the lab of Michael Hecker
  • 1996-1999: Basic studies in biology at the University of Potsdam (Germany)

Grants and Awards

  • 2008-2010: Two year postdoc grant of the German Research Council (DFG)
  • 2008: Ruth Massenberg Prize of Ruhr-University Bochum (Germany) for outstanding PhD thesis
  • 2008: Travel grant of FEMS
  • 2006: Travel grant of Ruth und Gert Massenberg Stiftung

Research interests

In general I like bacteria and complex systems.

A bit more detailed I enjoy working on:

  • Regulation of replication in bacteria
  • Synthetic chromosomes
  • Searching funny patterns on chromosomes or in proteins [1]


  1. Johnsen L, Flåtten I, Morigen, Dalhus B, Bjørås M, Waldminghaus T, and Skarstad K. The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication. Mol Microbiol. 2011 Jan;79(2):433-46. DOI:10.1111/j.1365-2958.2010.07453.x | PubMed ID:21219462 | HubMed [Line-2011]
  2. Stokke C, Waldminghaus T, and Skarstad K. Replication patterns and organization of replication forks in Vibrio cholerae. Microbiology (Reading). 2011 Mar;157(Pt 3):695-708. DOI:10.1099/mic.0.045112-0 | PubMed ID:21163839 | HubMed [Stokke-2011]
  3. Waldminghaus T, Weigel C, and Skarstad K. Replication fork movement and methylation govern SeqA binding to the Escherichia coli chromosome. Nucleic Acids Res. 2012 Jul;40(12):5465-76. DOI:10.1093/nar/gks187 | PubMed ID:22373925 | HubMed [Waldminghaus-2012]
  4. Gaubig LC, Waldminghaus T, and Narberhaus F. Multiple layers of control govern expression of the Escherichia coli ibpAB heat-shock operon. Microbiology (Reading). 2011 Jan;157(Pt 1):66-76. DOI:10.1099/mic.0.043802-0 | PubMed ID:20864473 | HubMed [Waldminghaus-2010-Gaubig]
  5. Waldminghaus T and Skarstad K. ChIP on Chip: surprising results are often artifacts. BMC Genomics. 2010 Jul 5;11:414. DOI:10.1186/1471-2164-11-414 | PubMed ID:20602746 | HubMed [Waldminghaus-2010]
  6. Waldminghaus T, Gaubig LC, Klinkert B, and Narberhaus F. The Escherichia coli ibpA thermometer is comprised of stable and unstable structural elements. RNA Biol. 2009 Sep-Oct;6(4):455-63. DOI:10.4161/rna.6.4.9014 | PubMed ID:19535917 | HubMed [Waldminghaus-2009-RNAbiology]
  7. Waldminghaus T and Skarstad K. The Escherichia coli SeqA protein. Plasmid. 2009 May;61(3):141-50. DOI:10.1016/j.plasmid.2009.02.004 | PubMed ID:19254745 | HubMed [Waldminghaus-2009]
  8. Waldminghaus T, Kortmann J, Gesing S, and Narberhaus F. Generation of synthetic RNA-based thermosensors. Biol Chem. 2008 Oct;389(10):1319-26. DOI:10.1515/BC.2008.150 | PubMed ID:18713019 | HubMed [Waldminghaus-2008]
  9. Waldminghaus T, Gaubig LC, and Narberhaus F. Genome-wide bioinformatic prediction and experimental evaluation of potential RNA thermometers. Mol Genet Genomics. 2007 Nov;278(5):555-64. DOI:10.1007/s00438-007-0272-7 | PubMed ID:17647020 | HubMed [Waldminghaus-2007-MGG]
  10. Waldminghaus T, Heidrich N, Brantl S, and Narberhaus F. FourU: a novel type of RNA thermometer in Salmonella. Mol Microbiol. 2007 Jul;65(2):413-24. DOI:10.1111/j.1365-2958.2007.05794.x | PubMed ID:17630972 | HubMed [Waldminghaus-2007-MolMicro]
  11. Narberhaus F, Waldminghaus T, and Chowdhury S. RNA thermometers. FEMS Microbiol Rev. 2006 Jan;30(1):3-16. DOI:10.1111/j.1574-6976.2005.004.x | PubMed ID:16438677 | HubMed [Narberhaus-2006]
  12. Waldminghaus T, Fippinger A, Alfsmann J, and Narberhaus F. RNA thermometers are common in alpha- and gamma-proteobacteria. Biol Chem. 2005 Dec;386(12):1279-86. DOI:10.1515/BC.2005.145 | PubMed ID:16336122 | HubMed [Waldminghaus-2005]
  13. Gerth U, Kirstein J, Mostertz J, Waldminghaus T, Miethke M, Kock H, and Hecker M. Fine-tuning in regulation of Clp protein content in Bacillus subtilis. J Bacteriol. 2004 Jan;186(1):179-91. DOI:10.1128/JB.186.1.179-191.2004 | PubMed ID:14679237 | HubMed [Gerth-2004]

All Medline abstracts: PubMed | HubMed

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