Chenlab: Difference between revisions

'''We are a bioinformatics lab interested in computational modeling of cell identity regulation in development and diseases'''. Different cell types in a healthy body share the same genetic sequence. Difference in identity of these cell types is determined by epigenetic regulation of gene expression. Meanwhile, many genetic variations in germ line or somatic cells were found to affect epigenetic factors, and can cause disease due to cell identity dysregulation. To study cell identity regulation in development, we are focused on endothelial lineage specification, and further work with collaborators to apply our knowledge to other cell lineages such as embryonic stem cell, cardiomyocyte, and neuron cells. To study cell identity dysregulation in diseases, the lab is focused on heart failure, and further works with collaborators to apply our knowledge to other diseases such as cancers, Rett Syndrome, and Hutchinson-Gilford Progeria Syndrome.