Chenlab:Softwares

Chen Laboratory

Center for Bioinformatics and Computational Biology
Department of Cardiovascular Sciences, The Methodist Hospital Research Institute
Department of Cardiothoracic Surgery, Weill Cornell Medical College, Cornell University

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• DANPOS (Chen et al, Genome Research, 2013): a set of 8 bioinformatics tools, including:

1. Dpos: comparative analysis of MNase-Seq data between samples.
2. Dpeak: comparative analysis ChIP-Seq data between samples.
3. Dregion: analyzing broad epigenetic domains, e.g., super enhancers.
4. Stat: statistical analysis of positions, peaks, or regions defined by DANPOS.
5. Selector: mapping positions, peaks, or regions to any given genomic features such as genes.
6. Profile: analyzing epigenetic signal at any given genomic regions, e.g., genes, enhancers.
7. Wiq: a tool for genome wide quantile normalization of epigenetic data.
8. Wig2Wiq: a tool for converting wiggle format file to wiq format.

• SpikeSCN (Hu and Chen, et al, Genes & Development, 2013). Genome structure and copy number variation analysis based on genome sequencing with spike-in control.

• BarVar ( Huang and Chen, et al, Cell reports, 2013). A bioinformatics pipeline to screen for drug-resistant genetic variations from barcode sequencing data.

• NucHMM (Chen et al, genomics proteomics bioinformatics, 2010). A Hidden Markov Model for nucleosome positioning prediction based on DNA sequence feature.

• GenomePSD (Chen et al, Nucleic acids research. 2008). A Power Spectrum Density analysis tool for genome sequence.

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