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We are a system biology lab interested in the epigenetic mechanisms that drive the change in cell identity in normal differentiation and tumorigenesis.

  • Develop bioinformatics technologies to gain novel biomedical insight into genome, epigenome, and transcriptome data.
  • Study transcriptional regulation mechanisms on the basis of cutting-edge bioinformatics technologies, and in combination with molecular, cellular, and animal experiments.


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Recent news:

April, 2018:

  • Dongyu's paper with Shilpa et al got accepted to Molecular Cell, the 19th paper published by our new lab, cheers!

Dec, 2017:

  • Dongyu's paper in collaboration with Sen et al was accepted to Nature Communications, the 16th paper published by our new lab, Cheers!

May, 2017:

  • We are proud to see that Houston Methodist has been named one of “America’s Best Employers” by Forbes magazine for the second year in a row.
  • Dr. Lei La will be a visiting scholar in our lab for 1 year. Dr. La is an Associate Professor at the Southern Medical University Nanfang Hospital ( a top hospital in China). Welcome!

April, 2017:

  • Kaifu provided a talk in the EB / ASBMB annual meeting 2017.
  • Dongyu's first-authorship manuscript for prostate cancer research is submitted, fingers crossed!
  • Dongyu's first-authorship manuscript for brain cancer research is submitted, fingers crossed!

March, 2017:

  • We become a member of the NCI-Funded Interdisciplinary Approaches to Cancer Metastasis Workshop, and will work together with the workshop to develop highly innovative and collaborative projects on cancer metastasis.
  • A manuscript is accepted by Elife. Alin and Kaifu are proud to help our collaborator interpret the 17 sets of RNA-Seq data. Cheers!

February, 2017:

  • A manuscript is accepted by the Nature Chemical Biology journal, Jie conducted the RNA-Seq analysis for this project. Cheers!

January, 2017:

  • Dr. Guangyu Wang from Beijing Institute of Genomiocs will join us as a postdoc soon, welcome!
  • Ms. Karen Lai from UT Austin will be an undergraduate intern in our lab this summer, welcome!

December, 2016:

  • A manuscript is accepted by the Science journal, Kaifu helps supervising the MNase-Seq and ChIP-Seq analysis and is a co-author. Cheers!

November, 2016:

  • Alin will start his tenure-track faculty position (assistant professor of statistics) at the Manhattan College. Congratulations!
  • Bo has joined the lab. Welcome onboard!

September, 2016

  • A manuscript is accepted to the Journal of the American Heart Association, Jie and Kaifu are co-authors, cheers!
  • A manuscript is accepted to the Nucleic Acids Research, Kaifu is a co-author, cheers!
  • Dr. Qingshu Meng will be visiting us for 1 year. Dr. Meng has outstanding background in Genomics research, and is a group leader at Beijing Institute of Genomics. Welcome!

August, 2016

  • Kaifu will be an adjunt assistant professor of Texas A&M.
  • Dr. Bo Xia from Georgia Tech will join us as a fresh postdoc soon. Dr. Xia is a PhD of biology and Master of computer science. Welcome!

April, 2016

  • Jie's paper was accepted by Molecular Cell, congratulations!

April, 2016

  • New postdoc position opening.
  • Jie's co-first authorship manuscript is under revision at Molecular Cell (IF 14), fingers crossed!

December, 2015

  • Kaifu's new manuscript was accepted to the Nucleic Acids Research, thank Alin for his help with the revision work!
  • A manuscript was accepted to the Molecular and Cellular Biology, thank Dongyu for his help with the revision work!

November, 2015

  • Dr. Jie Lu has joined us as postdoctoral Fellow, welcome onboard!

October, 2015

  • Dr. Dongyu Zhao has joined us as postdoctoral Fellow, welcome onboard!

September, 2015

August, 2015

  • Kaifu's data-revisiting paper is accepted to Nature Genetics, we find that conserved broad H3K4me3 uniquely marks tumor suppressor in normal cell types.
  • Kaifu's new manuscript is under the 3rd round review at Nature Genetics now.
  • Kaifu's MeCP2 mCH-binding paper (with Dr. Zoghbi lab) has been accepted to PNAS.





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