IGEM:Harvard/2006/DNA nanostructures

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Project Overview

  • Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
  • The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
  • As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
  • We expect that molecular containers could have several interesting scientific and clinical applications, such as
    • Drug and gene delivery
    • Bio-marker scavenging (early detection of biomarkers)
    • Directed evolution (compartmentalized selections)
    • Using multiplexing for combinatorial chemical synthesis
    • Capture and stabilization of multiprotein complexes
    • Protein folding (chaperones)
    • Cell sorting

Working Team Members

Recent Changes

16 July 2018

     07:43  McClean:YPG‎ (diff | hist) . . (+1). . Jidapas An-Adirekkun (talk | contribs) (Protocol)
     07:06  Chenlab:Recruiting‎ (diff | hist) . . (+2). . Kaifu Chen (talk | contribs)

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Endy:Stanford Lab Meetings‎‎ (3 changes | history) . . (+24). . [Kaisha Nekesa Benjamin‎ (3×)]

     

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(cur | prev) . . (+6). . Kaisha Nekesa Benjamin (talk | contribs) (Endy Lab Meetings Summer 2018)

     

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(cur | prev) . . (+19). . Kaisha Nekesa Benjamin (talk | contribs) (Endy Lab Meetings Summer 2018)

15 July 2018

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Chenlab:Recruiting‎‎ (8 changes | history) . . (-150). . [Kaifu Chen‎ (8×)]

     

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     12:02  Chenlab:Lab Members‎ (diff | hist) . . (+7). . Kaifu Chen (talk | contribs)
     00:45  Park Lab :Lab Members‎ (diff | hist) . . (+229). . Jeewoong Lee (talk | contribs) (Undergraduate Student)

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Park Lab :Publications‎‎ (2 changes | history) . . (+308). . [Jeewoong Lee‎ (2×)]

     

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(cur | prev) . . (+18). . Jeewoong Lee (talk | contribs) (Publications (*†equal contribution))

     

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13 July 2018

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(User creation log). .

[Yar‎ (2×)]

     

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. . User account Luca.ro20 (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

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. . User account Cecilyryan (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     17:13  BioMicroCenter:BioinfoClasses‎ (diff | hist) . . (-59). . Duanduan Ma (talk | contribs)

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Barnes:Contact‎‎ (2 changes | history) . . (+4). . [Jack R‎ (2×)]

     

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Barnes:Protocols‎‎ (12 changes | history) . . (+544). . [Jack R‎ (12×)]

     

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(cur | prev) . . (-52). . Jack R (talk | contribs) (General Molecular and Cell Biology Techniques)

     

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(Upload log). .

[Jack R‎ (6×)]

     

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. . Jack R (talk | contribs) uploaded File:Glycerol Stocks.pdf(Protocol for setting up glycerol stocks. Used for long-term storage of bacterial strains.)

     

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. . Jack R (talk | contribs) uploaded File:Syphonstat.pdf(Operating instructions for the syphonstat.)

     

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. . Jack R (talk | contribs) uploaded File:Electrocompetent Cells.pdf(Protocol for preparing electrocompetent cells, using a glycerol-manitol step.)

     

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. . Jack R (talk | contribs) uploaded File:Electroporation.pdf(Protocol for electroporation transformation of cells.)

     

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. . Jack R (talk | contribs) uploaded File:Flow-SOP.pdf(Instructions for starting up and running flow cytometer.)

     

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. . Jack R (talk | contribs) uploaded File:Gel electrophoresis.pdf(Protocol for carrying out an agarose gel electrophoresis.)

     06:18  Lee:Publications‎ (diff | hist) . . (+213). . Wooin Lee (talk | contribs) (2018)
     01:34  Barnes:Lab Members‎ (diff | hist) . . (+6). . Jack R (talk | contribs) (Alumni)

12 July 2018

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(Upload log). .

[ChanEngr‎ (2×)]

     

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     16:23 (User creation log) . . User account Alexagarcia (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎
     14:16  Beauchamp:ROIanalysis‎ (diff | hist) . . (+298). . Meghanr (talk | contribs) (What if the FreeSurfer parcellation doesn't work)

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Beauchamp:Unwarping‎‎ (2 changes | history) . . (+6,477). . [Meghanr‎ (2×)]

     

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(cur | prev) . . (+2,172). . Meghanr (talk | contribs) (Two EPIs with different phase encode directions)

     

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