IGEM:Harvard/2006/DNA nanostructures

• Project Overview
• Designs
• Notebook
• Protocols
• Presentations
• Literature

Project Overview

• Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
• The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
• As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
• We expect that molecular containers could have several interesting scientific and clinical applications, such as
  • Drug and gene delivery
  • Bio-marker scavenging (early detection of biomarkers)
  • Directed evolution (compartmentalized selections)
  • Using multiplexing for combinatorial chemical synthesis
  • Capture and stabilization of multiprotein complexes
  • Protein folding (chaperones)
  • Cell sorting

Working Team Members

• Tiffany Chan (talk, edits)
• Katherine Fifer (talk, edits)
• Valerie Lau (talk, edits)
• Matthew Meisel (talk, edits)
• Lewis Hahn (talk, edits)
• TA: Shawn Douglas (talk, edits)

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