Byrn lab:Publications

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Recent Publications

  1. Song, Yang; Yang, Xinghao; Chen, Xin; Nie, Haichen; Byrn, Stephen; Lubach, Joseph W., Investigation of Drug-Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy, Molecular Pharmaceutics (2015), Ahead of Print. DOI:10.1021/mp500692a
  2. Byrn, Stephen; Futran, Maricio; Thomas, Hayden; Jayjock, Eric; Maron, Nicola; Meyer, Robert F.; Myerson, Allan S.; Thien, Michael P.; Trout, Bernhardt L., Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them. 2014 Continuous Symposium, May 20-21, Journal of Pharmaceutical Sciences (2015), 104(3), 792-802.
  3. Fortunak, J.; Byrn, S.R.; Dyson, B.; Ekeocha, Z.; Ellison, T.; King, C.L.; Kulkarni, A.A.; Lee, M.; Conrad, C.; Thompson, K., An efficient, green chemical synthesis of the malaria drug, piperaquine, Tropical Journal of Pharmaceutical Research (2013), 12(5), 791-798.
  4. Lee, J.; Boerrigter, S.X.M.; Jung, Y.W.; Byun, Y.; Yuk, S.H.; Byrn, S.R.; Lee, E.H, Organic vapor sorption method of isostructural solvates and polymorph of tenofovir disoproxil fumarate, European Journal of Pharmaceutical Sciences (2013), 50(3-4), 253-262.
  5. Weber, J.K.R.; Benmore, C.J.; Tailor, A.N.; Tumber, S.K.; Neuefeind, J.; Cherry, B.; Yarger, J.L.; Mou, Q.; Weber, W.; Byrn, S.R. A neutron-X-ray, NMR and calorimetric study of glassy Probucol synthesized using containerless techniques, Chemical Physics (2013), 424, 89-92.
  6. Benmore, C.J.; Weber, J.K.R.; Tailor, A.N.; Cherry, B.R.; Yarger, J.L.; Mou, Q.; Weber, W.; Neuefeind, J.; Byrn, S.R., Structural characterization and aging of glassy pharmaceuticals made using acoustic levitation, Journal of Pharmaceutical Sciences (2013), 102(4), 1290-1300.
  7. Gurvich, V.J; Byrn, S.R., NIPTE: a multi-university partnership supporting academic drug development, Drug Discovery Today (2013), 18(19-20), 916-21. <li>Byrn, Stephen R, and Henck, Jan-Olav. Optimizing Physical Form – opportunities and limitations. Drug Discovery Today: Technologies 2012; 9(2): e73-e78.
  8. Lee EH, Byrn SR, Pinal R. The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments. J Pharm Sci 2012 Dec;101(12):4529-39. doi: 10.1002/jps.23316. Epub 2012 Sep 12.
  9. Trasi NS, Byrn SR. Mechanically induced amorphization of drugs: a study of the thermal behavior of cryomilled compounds. AAPS PharmSciTech 2012 Sep;13(3):772-84. doi: 10.1208/s12249-012-9801-8. Epub 2012 May 15. [PubMed - in process]
  10. Weber RJ, Benmore CJ, Tumber SK, Tailor AN, Rey CA, Taylor LS, Byrn SR. Acoustic levitation: recent developments and emerging opportunities in biomaterials research. Eur Biophys J 2012 Apr;41(4):397-403. doi: 10.1007/s00249-011-0767-3. Epub 2011 Oct 30.
  11. Su Z, Luthra S, Krzyzaniak JF, Agra-Kooijman DM, Kumar S, Byrn SR, Shalaev EY. Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water. J Pharm Sci 2011 Nov;100(11):4836-44. doi: 10.1002/jps.22690. Epub 2011 Jun 30.
  12. Byrn SR, Tishmack PA, Milton MJ, van de Velde H. Analysis of two commercially available bortezomib products: differences in assay of active agent and impurity profile. AAPS PharmSciTech 2011 Jun;12(2):461-7. Epub 2011 Apr 1.
  13. Lee, Eun Hee; Boerrigter, Stephan X. M.; Byrn, Stephen R. Epitaxy of a Structurally Related Compound on the (100) Faces of Flufenamic Acid Form I and III Single Crystals. Crystal Growth & Design 2010;10(2):518–527. doi: 10.1021/cg900549h. Epub January 8, 2010.
  14. Ito, Takanori; Byrn, Stephen; Chen, Xin; Carvajal, M. Teresa. Thermal insight of mechanically activated bile acid powders. Int J Pharm. 2011 Nov 25;420(1), 68-75.
  15. Emeje, Martins; Isimi, Christiana; Byrn, Stephen; Fortunak, Joseph; Kunle, Olobayo; Ofoefule, Sabinus. Extraction and physicochemical characterization of a new polysaccharide obtained from the fresh fruits of Abelmoschus esculentus. Iranian Journal of Pharmaceutical Research 2011; 10(2):237-246.
  16. Byrn, Stephen R.; Tishmack, Patrick A.; Milton, Mark J.; Velde, Helgi. Analysis of Two Commercially Available Bortezomib Products: Differences in Assay of Active Agent and Impurity Profile. AAPS PharmSciTech 2011 Jun;12(2):461-7. Epub 2011 Apr 1.
  17. Yamauchi, Masahiro; Lee, Eun Hee; Otte, Andrew; Byrn, Stephen R.; Carvajal, M. Teresa. Contrasting the Surface and Bulk Properties of Anhydrate and Dehydrated Hydrate Materials. Crystal Growth & Design 2011;11(3):692-698.
  18. Trasi, Niraj S.; Boerrigter, Stephan X. M.; Byrn, Stephen R.; Carvajal, Teresa M. Investigating the effect of dehydration conditions on the compactibility of glucose. Int J Pharm 2011;406(1-2):55-61.
  19. Mao, Chen; Prasanth Chamarthy, Sai; Byrn, Stephen R.; Pinal, Rodolfo. Theoretical and Experimental Considerations on the Enthalpic Relaxation of Organic Glasses using Differential Scanning Calorimetry. Journal of Physical Chemistry B 2010;114(1):269-279.
  20. Emeje, Martins; Olaleye, Olajide; Isimi, Christiana; Fortunak, Joseph; Byrn, Stephen; Kunle, Olobayo; Ofoefule, Sabinus. Oral sustained release tablets of zidovudine using binary blends of natural and synthetic polymers. Biological & Pharmaceutical Bulletin 2010;33(9):1561-157.
  21. Ripin, David H. Brown; Teager, David S.; Fortunak, Joseph; Basha, Shaik Mahaboob; Bivins, Nylea; Boddy, Christopher N.; Byrn, Stephen; Catlin, Kelly K.; Houghton, Stephen R.; Jagadeesh, S. Tirumala; et al. Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale. Organic Process Research & Development 2010;14(5):1194-1201.
  22. Lee, Eun Hee; Byrn, Stephen R. Stabilization of metastable flufenamic acid by inclusion of mefenamic acid: solid solution or epilayer? J Pharm Sci 2010;99(9):4013-4022.
  23. Engers, David; Teng, Jing; Jimenez-Novoa, Jonathan; Gent, Philip; Hossack, Stuart; Campbell, Cheryl; Thomson, John; Ivanisevic, Igor; Templeton, Alison; Byrn, Stephen; et al. A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion. J Pharm Sci 2010;99(9):3901-3922.

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