BYU iGEM/Notebook/12 January 2011

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12 January 2011

Continued Brainstorming

  • Caffeine synthesis (Starbacts :)
  • Creating a psychrophile (cold-loving) E. coli (E. skimocoli :) using phychrophilic proteins, chaperonins and UCP1
  • Pathogenic plasmid-sharing bacteria (shares lactase-encoding plasmid with other flora in gut)
  • Fabric (long bacteria that interlace ... create polymer within cell then allow to die ... when cell dies, long polymers are already interlaced)
  • Paper (decompose plant matter and create pulp that can be made into paper)
  • Sound detection (TRP proteins, MSCL + MSCS proteins in bacteria)
  • Organic nanowires
  • Electron sharing between species
  • Cell migration

We settled on Cancer detection, when all was said and done...

Colon Cancer Detection Mechanism Proposals for Continued Research

The idea is to detect various inputs and create unique reporters or levels of reporters according to inputs. To detect colon cancer we would focus on two or more of the following:

  • Unique metabolic products (Fermentation - lactic acids)
  • Reactive Oxygen Species (ROS)
  • Heat Detection (Riboswitch)
  • Collagen cutting enzymes (detect the byproducts)

Unique parts will include: ROS sensor (fine-tune those existing in nature), Riboswitch sensitive to specific temperature, and multi-input switch (creating our own).

Sample AND switch

Pamphlet Design

Trifold Pamphlet:

  • Who we are
  • What is iGEM
  • Our Goals within iGEM
  • What we need
  • How you can help

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