BME100 s2018:Group8 W1030 L1

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OUR TEAM

Name: Blake Hansen
Name: Bhavya Sharma
Name: Valeria Arvizu
Name: Ahmed Amer

LAB 1 WRITE-UP

Health Care Issue

Alzheimer’s Disease

Alzheimer's has been ranked as the 6th leading cause of death in the US. It affects 5.5 million Americans today. “Alzheimer's disease (AD) is the seventh leading cause of all deaths in the United States and is virtually tied with the sixth leading cause of death—diabetes. AD is the fifth leading cause of death in Americans aged 65 and older” (Alzheimer’s ASsociation, 2010). Alzheimer’s is a disease that affects the brain, specifically the Hippocampus, the part of the brain that helps form memories. The brain starts to lose neurons as they die off, eventually spreading the damage and shrinking the brain significantly. This makes it hard for those affected by Alzheimer’s to remember people, past memories, and day to day functions. Takin care of someone with alzheimer’s takes a lot of work and money, “In 2009, nearly 11 million family and other unpaid caregivers provided an estimated 12.5 billion hours of care to persons with AD and other dementias; this care is valued at nearly $144 billion” (Alzheimer’s Association, 2010). Our medical device would help those with Alzheimer’s to be more comfortable in their environment and help them complete daily activities and at the same time, helping caregivers and costs. The user would wear glasses that would provide: reminders, GPS tracking, facial recognition, audio and visual recording, and potentially work with other company devices (Apple, Google, Samsung, etc.)

Alzheimer' Association. “2010 Alzheimer's Disease Facts and Figures.” Alzheimer's & Dementia, vol. 6, no. 2, 2010, pp. 158–194., doi:10.1016/j.jalz.2010.01.009.

https://www.alz.org/alzheimers_disease_what_is_alzheimers.asp




Customer Validation

1. Alzheimer's Patients

     -Barnes, R. F., Raskind, M. A., Scott, M. and Murphy, C. (1981), Problems of Families Caring for Alzheimer Patients: Use of a Support Group. Journal of the American Geriatrics Society, 29: 80–85. doi:10.1111/j.1532-5415.1981.tb01233.x

2. Neurologists (Melinda Martin, MD, Homan Hajbandeh, MD)

3. Researchers (BrightFocus Foundation, Arizona Alzheimer's Consortium)

    -Moyer, Melinda Wenner. “Alzheimer's Researchers Call for Clinical Revamp.” Nature Medicine 17, 7 Mar. 2011, doi:10.1038/nm0311-235a.
    
    -https://www.alz.org/

4.Doctors specializing in Alzheimer's (Gary H. Salzman, Carol W. McMullin, Eric M Ossowski)

    -https://www.medicinenet.com/alzheimers_disease_causes_stages_and_symptoms/phoenix-az_city.htm

5. Apple

6. Google

7. Family Members

    -Barnes, R. F., Raskind, M. A., Scott, M. and Murphy, C. (1981), Problems of Families Caring for Alzheimer Patients: Use of a Support Group. Journal of the American Geriatrics Society, 29: 80–85. doi:10.1111/j.1532-5415.1981.tb01233.x

8. Alzheimer’s Association: Alzheimer’s Breakthrough Act (government research funding)

    -“Alzheimer's Breakthrough Act.” Alzheimner's Association, 2018, act.alz.org/site/PageServer?pagename=AlzheimersBreakthroughAct.

9. Universities

    -"Intellect Neurosciences Inks Collaboration Deal with Alzheimer's Research Group at University of California, Irvine." Professional Services Close-Up 24 Apr. 2012. Business Insights: Global. Web. 29 Jan. 2018.

10. Smart glass companies: Vue, Google glasses-“GLASS”

    -“Vue: Your Everyday Smart Glasses.” Vue: Your Everyday Smart Glasses, www.enjoyvue.com/
    -“Glass – Glass.” Glass, x.company/glass/

11. Occupational Therapists

    -Catherine Verrier Piersol, Lou Jensen, Deborah Lieberman, Marian Arbesman; Occupational Therapy Interventions for People With Alzheimer’s Disease. Am J Occup Ther 2017;72(1):7201390010p1-7201390010p6. doi: 10.5014/ajot.2018.721001.

12. World Health Organization

13. Local and National Hospitals (Banner Health, Mayo Clinic)

    -https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/care-at-mayo-clinic/mac-20350458
    -https://www.bannerhealth.com/search-results?keyword=Alzheimer%27s

14. Nursing Homes/Assisted Care Facilities

    -Barnes, R. F., Raskind, M. A., Scott, M. and Murphy, C. (1981), Problems of Families Caring for Alzheimer Patients: Use of a Support Group. Journal of the American Geriatrics Society, 29: 80–85. doi:10.1111/j.1532-5415.1981.tb01233.x

15. NIH (National Institutes of Health)

    -“Alzheimer's Disease and Related Dementias.” National Institutes of Health, 2018, www.nia.nih.gov/health/alzheimers.

16. National Institute on Aging

    -“Alzheimer's Disease and Related Dementias.” National Institutes of Health, 2018, www.nia.nih.gov/health/alzheimers.

17. Cure Alzheimer's Fund

    -“Cure Alzheimer's Fund.” Cure Alzheimer's Fund, 2018, curealz.org/.

18. Investors (i.e. Bill Gates)

    -Jefferson, Robin Seaton. “Bill Gates Gives $100 Million To Alzheimer's Research. Move Called Game Changer By Advocates.” Forbes, 13 Nov. 2017, www.forbes.com/sites/robinseatonjefferson/2017/11/13/bill-gates-gives-100-million-to-alzheimers-research-move-called-game-changer-by-advocates/#5334b1c22403.

19. Speech Language Pathologist

    -Cera, Maysa Luchesi, et al. “Phonetic and Phonological Aspects of Speech in Alzheimer’s Disease.”Aphasiology, vol. 32, no. 1, 4 Aug. 2017, doi:https://doi-org.ezproxy1.lib.asu.edu/10.1080/02687038.2017.1362687.

20. Biomedical Engineers

'




Competition

Solutions for Alzheimer's

Advantages

Disadvantages

Baidu Eye Glasses Records video and audio and connects to mobile devices. No GPS tracking, Bluetooth, facial recognition
Vue: Glasses (More for everyday use, users don’t normally have Alzheimer’s) Compatible w/ IOS and Android devices and apps

Bluetooth

Water resistant

Audio speakers that come from the glasses (gives info: weather, connects to phone for GPS instructions, siri, etc.)

Good battery life (2-3 days no charge)

Different sizes and shapes

Aesthetically pleasing

Financially Reasonable: $229

Consumers are appreciative of the design-not bulky

Lacks GPS tracking

No facial recognition

No integrated display

No reminders ( unless an app comes out with the ability to do so)

Not specifically for alzheimer’s or as a medical device Still under testing

Med-Minder (pill dispensing device) Pill dispenser that:

Reminds the user to take medication

Locks pills that are not supposed to be taken that day

Auto dispensers that refill empty pill slots

Custom greetings

Connects to mobile device

Medical alert

No audio or visual recording

User must remember or be near to the device to know what they need to do/hear it

Doesn’t remind them to do other activities throughout the day

Not financially reasonable: more than $60/month

S911 Bracelet Locator HC Locates where the user is at

Two way voice communication

Medical alert

Easy to use

Financially affordable: $185

Lacks visual and audio recording

No reminders

No facial recognition

Brain Simulation Along with recognition, it is also important to remember the feelings or emotions invoked for specific people. Johns Hopkins University has suggested an alternative to drugs, which is to “use of the low-voltage electrical charges delivered directly to the brain.” The device has been used previously, and it “provides deep brain stimulation… used in thousands of people with Parkinson’s disease, is seen as a possible means of boosting memory and reversing cognitive decline.” Like the research suggests, we can use EEGs to record the latest activity of the brain (specifically emotions and memory) upon recognizing an individual. Later on, when that face of voice is recognized again, similar simulations are invoked in the brain. Still under research

Surgical process

Class III Approval required

How would the design unfold?

Caution of targeting the correct region in the brain


Describe why your device product is more remarkable than other solutions presented:

Our device has a lot of similar qualities as the other solutions presented but ours brings all of the qualities together in a simple easy to use device. The glasses worn by the user will have GPS tracking, bluetooth, audio and visual recording, vital monitoring, integrated application systems (IOS, Android, mobile device connection) and it will all be monitored by a device the user owns or a device owned by a user’s relative. The glasses will be connected to a home station that allows charging and like the glasses, it gives direction through audio as well. The glasses will also have an integrated display that visually shows reminders, faces and the users relation to that person as well as the capability to show instructions on how to do daily activities (using the restroom, opening a can, folding laundry). Loved ones or caregivers that want to check on them will be able to do so by an app on their mobile device, allowing them to see past and live audio and visual recording. The glasses we have come up with take the amazing qualities of other devices and our own ideas, all into one.

Lee, Emma. “Chinese Search Engine Baidu Showcases Google Glass-like Baidu Eye.” TechNode, 3 Sept. 2014, technode.com/2014/09/03/chinese-search-engine-baidu-showcases-google-glass-like-baidu-eye/.

“Glass – Glass.” Glass, x.company/glass/

“Vue: Your Everyday Smart Glasses.” Vue: Your Everyday Smart Glasses, www.enjoyvue.com/

“Pill Dispenser.” MedMinder, 2017, www.medminder.com/ . Personal Locator. 2017, www.laipac.com/personal-locators.html.

“Johns Hopkins Surgeons Implant Brain ‘Pacemaker’ for Alzheimer’s Disease in United States as Part of a Clinical Trial Designed to Slow Memory Loss.” John Hopkins Medicine, 5 Dec. 2012, www.hopkinsmedicine.org/news/media/releases/johns_hopkins_surgeons_implant_brain_pacemaker_for_alzheimers_disease_in_united_states_as_part_of_a_clinical_trial_designed_to_slow_memory_loss.



IP Position

"Although there are no eyeglasses out there that are specifically focusing on Alzheimer's, there are some “smart glasses” available. One of the patented products is the Baidu Eye and VUE Glasses:

Baidu Eye This device is a wraparound headset with no screen or optical display. The glasses are able to sync information from the surroundings and then the information is stored on an application in the person’s phone. It claims to be able to watch movements in the hands and fingers and stores information on what you “circle” or touch/grab. The glasses schematics include many small gadgets including: micro projectors, memory modules and sensor modules. The device is claims to be able to respond to head nods, winking, blinking, and other gestures as well, all specifically assigned to do different actions or commands based on the user’s liking. The glasses are also meant to capture an image and come up with a solution to the problem captured. The glasses will connect to the internet through 3G, 4G and WIFI and will help aid in solving problems.

Assignee: Shangai Polytechnic School File date for patent: 2014-12-18

Baidu-eye1.jpg

Lee, Emma. “Chinese Search Engine Baidu Showcases Google Glass-like Baidu Eye.” TechNode, 3 Sept. 2014,technode.com/2014/09/03/chinese-search-engine-baidu-showcases-google-glass-like-baidu-eye/. https://www.google.com/patents/CN105759420A?cl=en&dq=Baidu+eye&hl=en&sa=X&ved=0ahUKEwjXybLZ3_7YAhUX8GMKHWO2DPkQ6AEIKTAA


VUE Glasses VUE glasses are for everyday use they include audio, bluetooth, app compatibility, and water resistance. They function as real glasses with the capability to work as a personal assistant through audio speakers in the glasses. The glasses connect with personal assistants (Siri) to help the user with everyday activities. With speakers on both sides of the glasses, you can listen to music, follow map directions, and a lot more. The glasses lack any visual aid in the lenses. They come in two different styles and connect with an app from Android or Apple stores.

Patent File Date: Work in Progress

Vueglasses.jpg

“Vue: Your Everyday Smart Glasses.” Vue: Your Everyday Smart Glasses, www.enjoyvue.com/ No note of a patent on Google Patents or other data bases

VUZIX VUZIX glasses are considered a “wearable computer” with the ability to connect to a broad spectrum of enterprise applications. The glasses have pre-installed apps that can be used to take video, pictures, track timed events and it will all connect to the user’s phone. The glasses are able to connect to the Android OS system.

The glasses are mostly used in telemedicine, remote assistance and warehousing at the moment, but plans to be expanded further.

Patent File Date: Work in Progress

Vuzixglasses.jpg

https://patents.google.com/patent/US20150338915A1/en?q=VUZIX&q=glasses&oq=VUZIX+glasses

Vuzix. “Vuzix M100 Smart Glasses.” Vuzix M100 Smart Glasses | Hands-Free Digital Data | Smart Glasses, www.vuzix.com/Products/m100-smart-glasses.




Fundability Worksheet

"Customer Validation (use a value of 1): 2

Masses have expressed interest in purchase: Big investors such as Bill Gates and the government have raised the funding amount for research. Universities, other companies and healthcare are constantly researching how to slow or stop Alzheimer’s, as well as provide help for Alzheimer’s patients. The number of people diagnosed with Alzheimer’s is constantly rising, causing a higher interest in buying devices to help those with Alzheimer’s.

Competitors: 2

Competitors exist but clinical improvements are still being sought: There are several companies (i.e. Google, Baidu) that are coming up with solutions for Alzheimer's. There are also companies that have made smart glasses that provide similar functions but is for a broader consumer range. They don’t provide specific help towards Alzheimer’s disease. Improvements are still being made to smart glasses and the specifications don’t collide with our ideas.

IP Position: 2

Non-provisional(s) filed and pending or Issued patents, but weak: A lot of the patents we have researched are either pending or have finally gotten patents approved after a longer period of time. But there are not that many patents out for this product. So we can’t say that getting a patent will be easy or fast, therefore it is weak. "