Karenliu

From OpenWetWare
Revision as of 04:28, 6 August 2013 by James Barrell (talk | contribs)
Jump to: navigation, search
The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links

Welcome to the Liu lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


<wikionly>

Recent updates to the lab wiki

23 May 2018

     14:01  Tomlinson:Birthdays‎ (diff | hist) . . (+9). . Ryan E. Tomlinson (talk | contribs) (Birthdays!)

     14:00 

Tomlinson:NewPeople‎‎ (3 changes | history) . . (+194). . [Ryan E. Tomlinson‎ (3×)]

     

14:00

(cur | prev) . . (+95). . Ryan E. Tomlinson (talk | contribs) (Mandatory)

     

14:00

(cur | prev) . . (+76). . Ryan E. Tomlinson (talk | contribs) (Mandatory)

     

14:00

(cur | prev) . . (+23). . Ryan E. Tomlinson (talk | contribs) (Mandatory)

     11:37  Xu lab:Lab Members‎ (diff | hist) . . (+191). . Peisheng Xu (talk | contribs)

     11:24 

Beauchamp:RestingState‎‎ (5 changes | history) . . (+4,890). . [Meghanr‎ (5×)]

     

11:24

(cur | prev) . . (0). . Meghanr (talk | contribs)

     

11:17

(cur | prev) . . (+744). . Meghanr (talk | contribs) (ICA using melodic)

     

08:51

(cur | prev) . . (+1,594). . Meghanr (talk | contribs) (ICA using melodic)

     

08:43

(cur | prev) . . (+993). . Meghanr (talk | contribs) (ICA using melodic)

     

08:31

(cur | prev) . . (+1,559). . Meghanr (talk | contribs) (ICA using melodic)

     11:22  Xu lab:Publications‎ (diff | hist) . . (+241). . Peisheng Xu (talk | contribs)

     11:22 

(Upload log). .

[Meghanr‎ (6×)]

     

11:22

. . Meghanr (talk | contribs) uploaded File:Melodic screenshot 06.jpg

     

11:22

. . Meghanr (talk | contribs) uploaded File:Melodic screenshot 05.jpg

     

11:21

. . Meghanr (talk | contribs) uploaded File:Melodic screenshot 04.jpg

     

11:21

. . Meghanr (talk | contribs) uploaded File:Melodic screenshot 03.jpg

     

11:21

. . Meghanr (talk | contribs) uploaded File:Melodic screenshot 02.jpg

     

11:21

. . Meghanr (talk | contribs) uploaded File:Melodic screenshot 01.jpg

N    07:42 

McClean:YPG‎‎ (4 changes | history) . . (+449). . [Jidapas An-Adirekkun‎ (4×)]

     

07:42

(cur | prev) . . (0). . Jidapas An-Adirekkun (talk | contribs) (Protocol)

     

07:42

(cur | prev) . . (+21). . Jidapas An-Adirekkun (talk | contribs) (Reagents)

     

07:40

(cur | prev) . . (+300). . Jidapas An-Adirekkun (talk | contribs)

N    

07:36

(cur | prev) . . (+128). . Jidapas An-Adirekkun (talk | contribs) (Created page with "YPG is a complex medium containing a nonfermentable carbon source (glycerol) that does not support the growth of petite mutants.")

     07:33  McClean:Protocols‎ (diff | hist) . . (+17). . Jidapas An-Adirekkun (talk | contribs) (Media)

N    06:36 

JiXu:Research‎‎ (2 changes | history) . . (+366). . [Ji Xu‎ (2×)]

     

06:36

(cur | prev) . . (+354). . Ji Xu (talk | contribs)

N    

00:23

(cur | prev) . . (+12). . Ji Xu (talk | contribs) (Created page with "To be edited")

N    06:25 

JiXu:Lab Members‎‎ (7 changes | history) . . (+1,317). . [Ji Xu‎ (7×)]

     

06:25

(cur | prev) . . (+1). . Ji Xu (talk | contribs)

     

06:23

(cur | prev) . . (+1). . Ji Xu (talk | contribs)

     

06:23

(cur | prev) . . (+2). . Ji Xu (talk | contribs)

     

06:22

(cur | prev) . . (+76). . Ji Xu (talk | contribs)

     

06:20

(cur | prev) . . (+8). . Ji Xu (talk | contribs)

     

06:20

(cur | prev) . . (+16). . Ji Xu (talk | contribs)

N    

06:19

(cur | prev) . . (+1,213). . Ji Xu (talk | contribs) (Created page with "Postdoc Fellowship 2011 to 2016 Department of Physiology, University of California Los Angeles, CA Areas of research: P2X receptors, glia cells, feedinng circuit...")

     00:21  JiXu:Contact‎ (diff | hist) . . (+27). . Ji Xu (talk | contribs)

22 May 2018

     19:41 (User creation log) . . User account Mariam50411 (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     17:59 

User:Margaret J. Oneil‎‎ (2 changes | history) . . (+119). . [Margaret J. Oneil‎ (2×)]

     

17:59

(cur | prev) . . (+107). . Margaret J. Oneil (talk | contribs) (Education: edited education)

     

17:57

(cur | prev) . . (+12). . Margaret J. Oneil (talk | contribs) (Contact Info: edited contact info)

     15:05  Yeo lab:Reprints‎ (diff | hist) . . (+59). . Yoonyeo (talk | contribs) (2018)

     10:08 

Beauchamp:UsingTORTOISE‎‎ (5 changes | history) . . (+2,048). . [Meghanr‎ (5×)]

     

10:08

(cur | prev) . . (+1). . Meghanr (talk | contribs)

     

10:07

(cur | prev) . . (+75). . Meghanr (talk | contribs)

     

10:07

(cur | prev) . . (-15). . Meghanr (talk | contribs)

     

09:46

(cur | prev) . . (+1,788). . Meghanr (talk | contribs)

     

08:15

(cur | prev) . . (+199). . Meghanr (talk | contribs)

     09:45 

(Upload log). .

[Meghanr‎ (4×)]

     

09:45

. . Meghanr (talk | contribs) uploaded File:Tortoise screenshot 05.jpg

     

09:41

. . Meghanr (talk | contribs) uploaded File:Tortoise screenshot 02.jpg

     

09:41

. . Meghanr (talk | contribs) uploaded File:Tortoise screenshot 04.jpg

     

09:41

. . Meghanr (talk | contribs) uploaded File:Tortoise screenshot 01.jpg

N    09:41 

Tomlinson:OneOnOne‎‎ (2 changes | history) . . (+153). . [Ryan E. Tomlinson‎ (2×)]

     

09:41

(cur | prev) . . (+2). . Ryan E. Tomlinson (talk | contribs)

N    

09:41

(cur | prev) . . (+151). . Ryan E. Tomlinson (talk | contribs) (Created page with "{{Tomlinson}} '''One on One Meeting Schedule:''' Emily - Wednesday at 10a Manisha - Wednesday at 1p Kim - Wednesday at 1:15p ''Updated: 5/22/2018''")

     09:40  Tomlinson:Internal‎ (diff | hist) . . (+52). . Ryan E. Tomlinson (talk | contribs) (Internal Stuff)
     09:23  OHSU Knight Cancer Institute Research Groups:OCI Cancer Journal Club‎ (diff | hist) . . (+29). . Mushui Dai (talk | contribs)
</wikionly>

<nonwikionly> This page was created using Open Wetware.</nonwikionly>