Jacobs

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Welcome to the Cell and Molecular Biomechanics Lab at Columbia University! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation. Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading. This work has applications in developing new therapies to age-related bone loss and osteoporosis. We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice. Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.

Recent updates to the lab wiki

22 October 2017

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     00:03 (Upload log) . . Joseph M Gurule (talk | contribs) uploaded File:Gradpic.jpg

21 October 2017

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. . Nicholas Y. Lee (talk | contribs) uploaded a new version of File:Jackie chan animated.gif

     

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     09:20  User:Dominique Brager/Notebook/481 Notebook/2017/10/10‎ (diff | hist) . . (+67). . Dominique Brager (talk | contribs) (Description)
     08:55  BME100 f2017:Group9 W1030 L4‎ (diff | hist) . . (-48). . Nicholas Y. Lee (talk | contribs) (OUR TEAM)
     08:44  Biomod/2017/StJohns‎ (diff | hist) . . (+90). . Alexkk15 (talk | contribs) (XXXNear and Future goalsXXX)