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Christopher Severyn

Sev WikiCover.jpg


Professional Appointments

Education & Training

Berkeley 2006 Sather Tower.JPG

Science & Medicine Twitter Feed

follow me on Twitter for a discussion on Science and Pediatric Medicine


Pediatric Medicine Links

  • Ways to focus and cope during hospitalizations and challenging times ImaginAction self-guided mindfulness / hypnosis.
  • Perspectives in patient care video, and children with autism video when they grow up.
  • Calculators:
  • NICHD Neonatal Research Network (NRN): Extremely Preterm Birth Outcome Data Neonate Calculator
  • Kawasaki Disease Calculator and the original paper in The Journal of Pediatrics.
  • The Newborn Weight Tool NEWT from Pen State Medical Center

Organizations and links to Pediatric Health Care

  • Packard Kids Connection @ LPCH, a great interactive site explaining select medical procedures to children and their parents (in English or Spanish), along with the “Power Penguin.”
  • Dual-Career Kit from the Stanford Clayman Institute for advancing equality through gender research

Hematology & Oncology Links


  • 2005-2010 Graduate Student at OHSU
  • 2018-Current: Research Fellow & Instructor in Pediatrics Hematology/Oncology/SCTRM at Stanford Univ.

Research Interests:

The Microbiome My current research focuses on understanding how the microbiome affects the pediatric hematology & oncology populations (including those individuals undergoing transplantation). Want to learn more about the basics of the Microbiome? Click here: The Invisible Universe

RGMc (Hemojuvelin) I previously studied the regulation of a gene called RGMc (also called Hemojuvelin (HJV) in humans). RGMc/HJV plays a critical role in iron metabolism, as inactivating mutations cause juvenile hemochromatosis, a severe iron overload disorder.

The long-range goals of this research are to enhance understanding of the molecular mechanisms by which evolution has shaped the regulation of gene expression in a family of genes, and apply this knowledge to understand select human diseases.

The primary focus of my research is three-fold:

(1) to understand the genomic structure of the Repulsive Guidance Molecule (RGM) family,

(2) to understand the mechanisms of transcriptional regulation of RGMc,

(3) to understand the basics of the molecular evolution of the RGM family.

An interactive Molecular Model of the RGM-family at the protein level

For the Transcriptional Regulation of RGMc, see this 2010 article in Genomics.

More Coming soon!

General Scientific Links (a.k.a., Teaching Science in the Community):

  • "Mini Med-School" lecture by Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the damage caused by sugary foods. He argues that (too much) fructose and (not enough) fiber appear to be cornerstones of the obesity epidemic through their effects on insulin. Series: UCSF Mini Medical School for the Public (7/2009; Health and Medicine, Show ID: 16717)
  • Learn about RNAi and gene regulation, with "a petunia, Pirate Ships, little Chefs, and 'the Cop'." (Intrigued? Click on the link and watch the video)
  • Want to know what Nanotechnology is? Find out in three minutes with the Nanosong by students at Cal.
  • The Powers of 10 expolores the range of sizes in our world, and our perspective in it. “We find that we inhabit an insignificant planet of a hum-drum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.” -Carl Sagan

More soon!


All Publications for C.J. Severyn on NCBI-PubMed

ResearcherID Link for C. Severyn

1. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family.

C. J. Severyn, U. Shinde and P. Rotwein, Biochem. J. (2009) v422:393-403 [1]

2. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle.

C. J. Severyn and P. Rotwein, Genomics (2010) v96:342–351 [2]

3. PhD Dissertation: Regulation and evolutionary origins of repulsive guidance molecule C / hemojuvelin expression : a muscle-enriched gene involved in iron metabolism

C. J. Severyn, OHSU Digital Commons (July 2010)[3]

4. In Translation: With Probiotics, Resistance Is Not Always Futile.

C. J. Severyn, A.S. Bhatt, Cell Host & Microbe (2018) v24:334–336 [4]

5. Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)

L. Spees, ...C. J. Severyn..., M.S. Kelly, et al., Biology of Bone Marrow Transplantation (BBMT) (2019) v25:756-763 [5]

6. Microbiota modification in hematology: still at the bench or ready for the bedside?

Severyn C.J., Brewster R., Andermann T.M. Blood Adv. (2019) v3(21):3461-3472 [6]

7. Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation.

Severyn C.J., Siranosian BA, Kong ST, Moreno A, Li MM, Chen N, Duncan CN, Margossian SP, Lehmann LE, Sun S, Andermann TM, Birbrayer O, Silverstein S, Kim S, Banaei N, Ritz J, Fodor AA, London WB, Bhatt AS, Whangbo JS. JCI Insight. (2022) Mar 3:e154344. doi: 10.1172/jci.insight.154344. Online ahead of print [7].




See some of my photographs including this image of Mount Hood in Oregon:

Mount Hood Alpenglow.JPG

WebCams and other links

  • Or the eastern side of the Sierra Nevada with Mono Lake
  • An archive of the development of the 1960 Master Plan for Higher Education in California and how Public Education & Health should be at the forefront of our society. It begins with providing access to a world-class education for students of all means, and then moving forward to improve our society at the level of the State, the Nation, and the World.

Course Web Pages

OHSU 2007 Course: Adv. Topics in Molecular Biology

BMCB625 Advanced Topics in Molecular Biology


Home        People        Materials        Schedule        Help        Discussion       

Discussion Questions and Presentations: Chris

DNA Replication Discussion Qsts
Exon Junction Complex BMCB625:Exon_Jxn_Complex
Link to Universal Template BMCB625:Discussion_Univ_template
Mathematics in Biology BMCB625:Mathematics_in_Biology