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Complete List of PublicationsTomlinson Pubmed Recent Highlighted PublicationsThe TrkA agonist gambogic amide augments skeletal adaptation to mechanical loading The Role of Nerves in Skeletal Development, Adaptation, and Aging Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion Fracture repair requires TrkA signaling by skeletal sensory nerves. Naproxen impairs load-induced bone formation, reduces bone toughness, and diminishes woven bone formation following stress fracture in mice. NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice. NGF-TrkA signaling by sensory nerves coordinates the vascularization and ossification of developing endochondral bone. |