34
edits
Harvard:SysBio 204/2016: Difference between revisions
From OpenWetWare
Jump to navigationJump to search
no edit summary
(New page: Josie test) |
Weidong Xu (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
Josie | {{Template:Harvard:SysBio_204_blue|2015}} | ||
==Course overview== | |||
*A course focusing on the rational design, construction, and applications of nucleic acid and protein-based synthetic molecular and cellular machinery and systems. Students are mentored to produce substantial term projects. | |||
*Intended for graduate students in Systems Biology, Biophysics, Engineering, Biology and related disciplines. No formal prerequisites. Projects are tailored to each student's strengths and interests. | |||
*Website: http://sb204.net | |||
*Poster: http://openwetware.org/images/e/e0/Sb204.2015.pdf | |||
==Midterm and Final== | |||
*There will be two midterms and one final project for this class | |||
**Policy: strict submission deadline, we encourage you to submit your work the night before | |||
**Midterm #1 due: 12pm Monday Oct. 5th (slides, video), and 12pm Monday Oct. 12th (report, sequences) | |||
**Midterm #2 due: 12pm Monday Nov. 2nd (slides, video), and 12pm Monday Nov. 9th (report, sequences) | |||
**Final project due: 12pm Monday Nov. 30th (slides), and 12pm Monday Dec. 7th (report, sequences) | |||
**Method of submission: email slides and presentations to TA and submit them to Dropbox folder shared by TF | |||
*[http://openwetware.org/images/5/5c/SB204_2015-Project-reformat.pdf Midterm and Final Projects (may be updated)] | |||
==Logistics== | |||
*Instructors: George Church, William Shih, Pamela Silver, Peng Yin | |||
*Teaching Fellow: Josie Kishi (jkishi@g.harvard.edu) | |||
*Meeting time: 2:30 - 4:00 PM, Mon/Wed, Fall 2015 | |||
*Location: Room 521, Wyss Institute, 3 Blackfan circle, Boston, 02115 | |||
*First class on Wednesday Sep 2nd. | |||
*No exams | |||
*Prerequisites: none | |||
*Grading | |||
**20% Participation | |||
**40% Midterm projects | |||
**40% Final project | |||
* [https://canvas.harvard.edu/courses/6474 Harvard course site] | |||
==Example topics for final design project== | |||
*'''miRNA pattern recognition in eukaryotic cells''' | |||
*'''Directed evolution of chemical sensors''' | |||
*'''Nano-breadboards for probing electron transport in proteins''' | |||
*'''Altered genetic codes and amino acid alphabets''' | |||
*'''Modification of proteins for function in harsh environments''' | |||
*'''Automatable assembly of large synthetic genes and circuits''' | |||
*'''Synthetic biology of stem cells and epigenetic reprogramming pathways''' | |||
*'''Structural re-engineering of adenoviruses''' | |||
*'''Artificial chemotactic swimmers''' | |||
*'''Nonequilibrium networks of nano-machines mimicking dynamic instability in the cytoskeleton''' | |||
*'''Recombinase-based multi-state memory in bacteria''' | |||
*'''Exosome manufacturing''' | |||
*'''Self-assembled solar energy harvester based on bio-inorganic nano-antennae for uv-vis''' | |||
*'''Systematic debugging of DNA labeling chemistries by atomic-resolution TEM imaging of DNA origami''' | |||
*'''Transcriptional activation and repression through rational molecular design''' | |||
*'''Tissue engineering scaffold nano-materials''' | |||
*'''Programmable multistep chemical synthesis by templating on catalytic nanostructures''' | |||
*'''Ultra-sensitive signal processing for synthetic biology''' | |||
*'''Antibody 2.0''' | |||
*'''Synthetic nanostructure - virus conjugates''' | |||
*'''Replication of information in synthetic crystals''' | |||
*'''Cheap large-scale production of protein or DNA-based materials''' | |||
*'''Etc. Etc. Etc.''' | |||
==Background Info and previous class projects== | |||
*'''BPH242r 2008-2009''' http://openwetware.org/wiki/Biophysics_242r/2009 (Synthetic Biology) | |||
*'''BPH242r 2010-2011''' http://openwetware.org/wiki/Harvard:Biophysics_242r/2011 (Biologically Inspired Molecular Engineering) | |||
*'''SB204 2011-2012''' http://openwetware.org/wiki/Harvard:SysBio_204/2011 | |||
**[http://isites.harvard.edu/icb/icb.do?keyword=k83102 Harvard Course Site] | |||
*'''SB204 2012-2013''' http://openwetware.org/wiki/Harvard:SysBio_204/2012 | |||
**[http://isites.harvard.edu/icb/icb.do?keyword=k87016 Harvard Course Site] | |||
*'''SB204 2013-2014''' http://openwetware.org/wiki/Harvard:SysBio_204/2013 | |||
**[http://isites.harvard.edu/icb/icb.do?keyword=k98865 Harvard Course Site] | |||
*'''SB204 2013-2014''' http://openwetware.org/wiki/Harvard:SysBio_204/2014 | |||
**[http://isites.harvard.edu/icb/icb.do?keyword=k106678 Harvard Course Site] | |||
