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Tony Atala: Artificial Bladder by Krishnendu Saha: Difference between revisions
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Tony Atala: Artificial Bladder by Krishnendu Saha (view source)
Revision as of 07:03, 10 April 2013
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A very small piece of the bladder is cut off from the patient usually smaller than the size of a postage stamp. It is very important that the biopsied bladder piece be free from disease. A biodegradable scaffold is molded in the shape of a bladder, this is after a CT scan has been performed on the patient to check the precise dimensions. The cells obtained from the bladder piece are grown outside the body for 7 to 10 days. These cells are urothelial cells. After that are seeded or 'painted' onto the scaffold. This is now put into and oven like device at body temperature and 95% oxygen for about 6 weeks. After this time the organ is ready to be implanted into the patient. | A very small piece of the bladder is cut off from the patient usually smaller than the size of a postage stamp. It is very important that the biopsied bladder piece be free from disease. A biodegradable scaffold is molded in the shape of a bladder, this is after a CT scan has been performed on the patient to check the precise dimensions. The cells obtained from the bladder piece are grown outside the body for 7 to 10 days. These cells are urothelial cells. After that are seeded or 'painted' onto the scaffold. This is now put into and oven like device at body temperature and 95% oxygen for about 6 weeks. After this time the organ is ready to be implanted into the patient. | ||
===Advantages and Limitations=== | |||
*Current gold standard for bladder replacements involve the use of tissue grafts from bowel. However, the intestine is designed to absorb nutrients and the bladder is designed to excrete, patients who have this procedure are plagued with many problems including reabsorption of toxins, formation of stones and kidney damage. | |||
Eliminate the risk of organ rejection because the patient is using cells obtained from their own body | Eliminate the risk of organ rejection because the patient is using cells obtained from their own body | ||
Reduce or eliminate other adverse effects of existing procedures such as osteoporosis. Currently the orthotopic neobladder procedure which makes use of intestinal cells causes the body to absorb calcium and other substances that the bladder would originally get rid of (causing osteoporosis). | Reduce or eliminate other adverse effects of existing procedures such as osteoporosis. Currently the orthotopic neobladder procedure which makes use of intestinal cells causes the body to absorb calcium and other substances that the bladder would originally get rid of (causing osteoporosis). | ||
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In 2000, he was awarded the $100,000 Christopher Columbus Foundation Award given to a living American who is currently working on a discovery that will significantly affect society | In 2000, he was awarded the $100,000 Christopher Columbus Foundation Award given to a living American who is currently working on a discovery that will significantly affect society | ||
Tengion received $50 million dollars in series B financing for the Neo-Bladder Augment clinical trials and development | Tengion received $50 million dollars in series B financing for the Neo-Bladder Augment clinical trials and development | ||
==References== | ==References== | ||
*[1] http://www.nature.com/nbt/journal/v17/n2/full/nbt0299_149.html | *[1] http://www.nature.com/nbt/journal/v17/n2/full/nbt0299_149.html | ||
