94
edits
Tony Atala: Artificial Bladder by Krishnendu Saha: Difference between revisions
From OpenWetWare
Jump to navigationJump to search
Tony Atala: Artificial Bladder by Krishnendu Saha (view source)
Revision as of 12:26, 10 April 2013
, 10 April 2013→Advantages and Limitations
| Line 42: | Line 42: | ||
===Advantages and Limitations=== | ===Advantages and Limitations=== | ||
*Current gold standard for bladder replacements involve the use of tissue grafts from bowel. However, the intestine is designed to absorb nutrients and the bladder is designed to excrete, patients who have this procedure are plagued with many problems including reabsorption of toxins, formation of stones and kidney damage. | *Current gold standard for bladder replacements involve the use of tissue grafts from bowel. However, the intestine is designed to absorb nutrients and the bladder is designed to excrete, patients who have this procedure are plagued with many problems including reabsorption of toxins, formation of stones and kidney damage. Moreover, intestinal cells causes the body to absorb calcium, leading to osteoporesis. | ||
*It eliminates the risk of organ rejection because the patient is using cells obtained from their own body. | |||
However, the scientists arose concern that the technology can be challenging to the elderly people who have limited regenerative capacity to obtain sufficient amount cells for the transplantation. One more question remains that for the bladder cancer patients who have malignant urothelial cells. Harvesting and culturing the malignant cells can increase the possibility of malignant cell transplantation back to the body. Steve Chung of Advanced urology Institute of Illionis commented that "Atala and his colleagues should be praised for the milestone they have reached, but further multi-institutional studies are needed with longer follow-up. Until then surgery using intestinal tissue to repair the bladder remians the gold standard." [ | |||
Right now, the biggest hurdle faced by Tengion is getting the artificial bladder approved by the Food and Drug Administration | Right now, the biggest hurdle faced by Tengion is getting the artificial bladder approved by the Food and Drug Administration | ||
