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The human immunoglobulin and T-cell receptors are constantly undergoing evolutionary selection and amplification. As such, they can monitor and remember the antigenic history throughout one's life. The aim of VDJ-ome is to capture and sequence a large pool of heavy and light Ig chains, in addition to T-cell receptors at a single cell level. We will attempt to correlate the VJD-ome sequence variation with a table of antigens and exposure in humans. Reading the status of the immunoglobulin complexity in real-time may help us to understand the molecular basis for autoimmune disorders, environmental allegens, and tissue and organ engraftment at an individual patient level in real time.