Maureen Hoatlin

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Official description from OHSU Faculty Page Welcome My name is Maureen Hoatlin, and I'm currently at Oregon Health and Science University in Portland, Oregon. My lab joined OpenWetWare in 2006. We use OWW almost every day for our lab website, sharing our reagents and protocols, and organizing courses and seminars series. You can email me through OpenWetWare or contact me by: Phone: 503-494-1123 OWW users: Post a message on my talk page LinkedIn Profile Research Interests We are interested in understanding how cells maintain genomic stability. One of the mechanisms that regulates this critical process is defective in Fanconi anemia (FA), a genetic model for human susceptibility to cancer. FA is a rare but devastating multi-gene disease thought to have an underlying defect in DNA interstrand crosslink repair. Our lab pioneered the use of cell-free assays for FA proteins in extracts from Xenopus eggs. These extracts allow analysis of FA protein function and post-translational modifications in a context that is permissive for naturally-regulated DNA synthesis. The recruitment of Fanconi proteins to chromatin in S-phase is providing us with a biochemical platform for elucidating the molecular function of the Fanconi proteins during the DNA damage response. OWW Links and Pages in Progress Research Hoatlin Lab Courses and Educational Activities Course Directed using OWW: Advanced Biochemistry Course In Progress: Description/Paper about the Advanced Biochemistry Course hosted on OWW Cross-Departmental Focus Group wiki 2006-2007 OHSU DNA Replication, Recombination and Repair (R3) Club. Administration/Service Seminar Series Organized on OWW OHSU Biochemistry Seminar Series Development of BMB Writing Class for credit BMB Current Course Descriptions BMB training Grant Ideas Outreach Scientific American article on OWW Waldrop MM. Science 2.0. Sci Am. 2008 May;298(5):68-73. DOI:10.1038/scientificamerican0508-68 | Teaching/Mentoring Medical Students, here are your movies: DNA wrapping Replication Fork Other teaching resources Link to my teaching reference suggestions on Amazon My Amazon List of References for Lab Management DNAGearheads, Lab Citeulike site for DNA related articles Roton Intro Form Roton Evaluation Form see section above for links to class web sites More Early Factoids, in chronological order, with some fun links B.S. in Chemistry from Old Dominion University Analytical Chemist SRI International in Menlo Park. Analysis of natural products and nucleoside anti-tumor agents (my favorite compound) Research associate at Genentech, Inc, starting in nucleoside chemistry but defecting quickly to molecular biology to clone and express proteins of clinical interest, including work on recombinant subunit vaccines for treatment of Rabies, Polio, HIV, and Foot and Mouth Disease. We went to Plum Island to get FMDV cloned. The picture of us (see me in circle) in the Plum Island containment facility has a life of its own. Graduate research at OHSU with David Kabat, focusing on retroviral mediated pathogenesis in hematopoiesis and genes that control host susceptibility to cancer Postgraduate work in Hematology and Oncology, Founding Director of the OHSU Cancer Center Cell Culture Facility Visiting scientist at the Free University of Amsterdam in 1998-1999 Joined Molecular Medicine as an Assistant Professor in 2000 Biochemistry and Molecular Biology absorbed components of Mol Med (including me) in 2005 Hoatlin:Archives Back to Main Page Hoatlin Lab