Imperial College/Courses/Spring2008/Synthetic Biology/Computer Modelling Practicals/Practical 2/Report

From OpenWetWare
Jump to navigationJump to search
Synthetic Biology (Spring2008): Computer Modelling Practicals


Home        CellDesigner Tutorial        Practical 1        Practical 2        Practical 3        Schedule        Back to Synthetic Biology Course       

<html> <body> <!-- Start of StatCounter Code --> <script type="text/javascript"> var sc_project=3315875; var sc_invisible=0; var sc_partition=36; var sc_security="779debd0"; </script> <script type="text/javascript" src=""></script><noscript><div class="statcounter"><a class="statcounter" href=""><img class="statcounter" src="" alt="web metrics" /></a></div></noscript> <!-- End of StatCounter Code --> </body> </html>

Practical 2: Report Structure

  • Name:
  • Department:

Part I: Constitutive Gene Expression

  1. [mRNA] expression when at steady state, [Protein] expression when at steady state
  2. average transcription rate, average translation rate
  3. Simulation output
  4. Sensitivity Analysis on the protein steady state with regards to the 4 parameters (parameter scan outputs)
  5. under quasi-steady-state assumption on [mRNA], expression of 's' and 'd'
  6. model comparison: illustration + comments.

Part II: Activated and Repressed Gene Expression

  1. transfer function graph for the repressor circuit
  2. possible application of the repressor circuit
  3. transfer function graph for the activator circuit
  4. possible application of the activator circuit

Part III: Feedback Gene Expression

  1. Provide ODEs system for the 3 circuits
  2. Model comparison with illustrations + comments