Imperial College/Courses/Fall2008/Synthetic Biology (MRes class)

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Fall 2008 - Synthetic Biology (MRes class)

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Fall 2008

Instructor: Vincent Rouilly


Synthetic Biology Foundations Prism


  • The lecture for the Synthetic Biology MRes will take place on Tuesday 2nd December between 10.00am-12.00pm, in Room B213, Biochemistry Building.
  • Registration to OpenWetWare required ( join OWW ).

Scope of the lecture

Part I: The Synthetic Biology landscape

  • What are the current biotechnologies around ?
  • Driving concepts and technologies in Synthetic Biology.
  • Current Synthetic Biology activities (how to get involved?).

Part II: Journal club (teams of 2)

  1. Canton B, Labno A, and Endy D. Refinement and standardization of synthetic biological parts and devices. Nat Biotechnol. 2008 Jul;26(7):787-93. DOI:10.1038/nbt1413 | PubMed ID:18612302 | HubMed [paper1]
  2. Arkin A. Setting the standard in synthetic biology. Nat Biotechnol. 2008 Jul;26(7):771-4. DOI:10.1038/nbt0708-771 | PubMed ID:18612298 | HubMed [paper2]
  3. Lucks JB, Qi L, Whitaker WR, and Arkin AP. Toward scalable parts families for predictable design of biological circuits. Curr Opin Microbiol. 2008 Dec;11(6):567-73. DOI:10.1016/j.mib.2008.10.002 | PubMed ID:18983935 | HubMed [paper3]
  4. Beisel CL, Bayer TS, Hoff KG, and Smolke CD. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Mol Syst Biol. 2008;4:224. DOI:10.1038/msb.2008.62 | PubMed ID:18956013 | HubMed [paper4]
All Medline abstracts: PubMed | HubMed

Register here to present one of the papers during the class (15-20min presentation with slides between 2 people).

  • Team 1 (Chris / Tom): Arkin A. Setting the standard in synthetic biology. Nat Biotechnol 2008 Jul; 26(7) 771-4. doi:10.1038/nbt0708-771 pmid:18612298.
  • Team 2 (Name 1 / Name 2): ...specify paper...

Part III: Case study (teams of 2)

  • Congratulations ! You have just won a 3 year seed funding to produce some Synthetic Biology work.
  • You have unlimited access to a wet lab and dry lab
  • What do you do next ? How do you do it ? What do you plan to deliver ? What will be your contribution to Synthetic Biology ?

Register here your team:

  • Team 1 (Name 1 / Name 2)
  • Team 2 (Name 1 / Name 2)