Graduate work was focused on variant non-catalytic RNA polymerase subunits and their surprising role for the functional specification of RNA silencing RNA Polymerases IV and V in the small RNA directed DNA methylation pathway, as well as the role of DNA demethylation in multi-megabase epigenetic silencing in the laboratory of Craig Pikaard.
Undergraduate research project included map-based cloning and characterization of mutants from a forward genetics screen for genes regulating Innate Immunity in the laboratory of Xinnian Dong.
Tan, E.H., Ream, T.S., Blevins, T. and Pikaard, C.S. (2012) Functional consequences of subunit diversity in RNA Polymerase II and V. Cell Reports 1, 208–214, March 29, 2012.
Mosher, A. R., Tan, E.H., Shin, J., Fischer, R.L., Pikaard, C.S., Baulcombe, D.C. (2011) An atypical epigenetic mechanism affects uniparental expression of Pol IV-dependent siRNAs. PloS ONE 6(10): e25756.
Song, J., Durrant, W.E., Wang, S., Yan, S., Tan, E.H., Dong, X. (2011) DNA repair proteins are directly involved in regulation of gene expression during plant Immune Response. Cell Host & Microbe, 9(2): 115-124.