Our main interest is to better understand the cellular and molecular basis for generation and maintenance of regulatory T cells (Tregs) in the suppression of autoimmunities and/or allergies in mouse models. We have been using intravital microscopy as the starting point for the in vivo imaging of Tregs. We are evaluating what and where the important cell-cell contacts for Tregs generation/function happen. For that, we are using multi-photon microscopy, developing new intravital surgical tecniques and tools, and using animal models that develop autoimmune and allergic diseases. We hope that a better comprehension of generation and function of Tregs will be crucial for the development of new therapies against human autoimmune and allergic diseases. Our lab is located at the Unit of Cell Imaging, IGC, Portugal.
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- Kim JV, Jiang N, Tadokoro CE, Liu L, Ransohoff RM, Lafaille JJ, and Dustin ML. Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods. 2010 Jan 31;352(1-2):89-100. DOI:10.1016/j.jim.2009.09.007 |
- Maraver A, Tadokoro CE, Badura ML, Shen J, Serrano M, and Lafaille JJ. Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood. 2007 Nov 1;110(9):3218-25. DOI:10.1182/blood-2007-01-070359 |
- Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, and Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006 Sep 22;126(6):1121-33. DOI:10.1016/j.cell.2006.07.035 |