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Our main interest is to better understand the cellular and molecular basis for generation and maintenance of regulatory T cells (Tregs) in the suppression of autoimmunities and/or allergies in mouse models. We have been using intravital microscopy as the starting point for the in vivo imaging of Tregs. The use of a multi-photon microscope, the development of new intravital surgical tecniques and tools, and use of animal models that develop autoimmune and allergic diseases, we are evaluating what and where the important cell-cell contacts for Tregs generation/function happen. We hope that a better comprehension of generation and function of these Tregs will be crucial for the development of new therapies against human autoimmune and allergic diseases. Our lab is located at the Unit of Cell Imaging, IGC, Portugal.

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  1. Maraver A, Tadokoro CE, Badura ML, Shen J, Serrano M, and Lafaille JJ. Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood. 2007 Nov 1;110(9):3218-25. DOI:10.1182/blood-2007-01-070359 | PubMed ID:17626841 | HubMed [Paper1]
  2. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, and Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006 Sep 22;126(6):1121-33. DOI:10.1016/j.cell.2006.07.035 | PubMed ID:16990136 | HubMed [Paper2]
  3. Tadokoro CE, Shakhar G, Shen S, Ding Y, Lino AC, Maraver A, Lafaille JJ, and Dustin ML. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med. 2006 Mar 20;203(3):505-11. DOI:10.1084/jem.20050783 | PubMed ID:16533880 | HubMed [Paper3]
  4. Shen S, Ding Y, Tadokoro CE, Olivares-Villagómez D, Camps-Ramírez M, Curotto de Lafaille MA, and Lafaille JJ. Control of homeostatic proliferation by regulatory T cells. J Clin Invest. 2005 Dec;115(12):3517-26. DOI:10.1172/JCI25463 | PubMed ID:16294223 | HubMed [Paper4]
  5. Martín AP, de Moraes LV, Tadokoro CE, Commodaro AG, Urrets-Zavalia E, Rabinovich GA, Urrets-Zavalia J, Rizzo LV, and Serra HM. Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2056-63. DOI:10.1167/iovs.04-0418 | PubMed ID:15914623 | HubMed [Paper5]
  6. Oliveira MA, Tadokoro CE, Lima GM, Mosca T, Vieira LQ, Leenen PJ, and Abrahamsohn IA. Macrophages at intermediate stage of maturation produce high levels of IL-12 p40 upon stimulation with Leishmania. Microbes Infect. 2005 Feb;7(2):213-23. DOI:10.1016/j.micinf.2004.10.013 | PubMed ID:15725387 | HubMed [Paper6]
  7. Pinge-Filho P, Peron JP, de Moura TR, Menolli RA, Graça VK, Estevão D, Tadokoro CE, Jankevicius JV, and Rizzo LV. Protective immunity against Trypanosoma cruzi provided by oral immunization with Phytomonas serpens: role of nitric oxide. Immunol Lett. 2005 Jan 31;96(2):283-90. DOI:10.1016/j.imlet.2004.09.010 | PubMed ID:15585334 | HubMed [Paper7]
  8. Martins GA, Campanelli AP, Silva RB, Tadokoro CE, Russo M, Cunha FQ, Rizzo LV, and Silva JS. CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection. Microbes Infect. 2004 Nov;6(13):1133-44. DOI:10.1016/j.micinf.2004.07.002 | PubMed ID:15488732 | HubMed [Paper8]
  9. Eckley CA, Michelsohn N, Rizzo LV, Tadokoro CE, and Costa HO. Salivary epidermal growth factor concentration in adults with reflux laryngitis. Otolaryngol Head Neck Surg. 2004 Oct;131(4):401-6. DOI:10.1016/j.otohns.2004.01.020 | PubMed ID:15467608 | HubMed [Paper9]
  10. Tadokoro CE, Vallochi AL, Rios LS, Martins GA, Schlesinger D, Mosca T, Kuchroo VK, Rizzo LV, and Abrahamsohn IA. Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi. J Autoimmun. 2004 Sep;23(2):103-15. DOI:10.1016/j.jaut.2004.05.003 | PubMed ID:15324929 | HubMed [Paper10]
  11. Malvezi AD, Cecchini R, de Souza F, Tadokoro CE, Rizzo LV, and Pinge-Filho P. Involvement of nitric oxide (NO) and TNF-alpha in the oxidative stress associated with anemia in experimental Trypanosoma cruzi infection. FEMS Immunol Med Microbiol. 2004 May 1;41(1):69-77. DOI:10.1016/j.femsim.2004.01.005 | PubMed ID:15094169 | HubMed [Paper11]
  12. Martins GA, Tadokoro CE, Silva RB, Silva JS, and Rizzo LV. CTLA-4 blockage increases resistance to infection with the intracellular protozoan Trypanosoma cruzi. J Immunol. 2004 Apr 15;172(8):4893-901. DOI:10.4049/jimmunol.172.8.4893 | PubMed ID:15067068 | HubMed [Paper12]
  13. Tadokoro CE and de Almeida Abrahamsohn I. Bone marrow-derived macrophages grown in GM-CSF or M-CSF differ in their ability to produce IL-12 and to induce IFN-gamma production after stimulation with Trypanosoma cruzi antigens. Immunol Lett. 2001 May 1;77(1):31-8. DOI:10.1016/s0165-2478(01)00197-3 | PubMed ID:11348667 | HubMed [Paper13]
  14. Grisotto MG, D'Império Lima MR, Marinho CR, Tadokoro CE, Abrahamsohn IA, and Alvarez JM. Most parasite-specific CD8+ cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-alphabeta and CD8 molecules. Immunology. 2001 Feb;102(2):209-17. DOI:10.1046/j.1365-2567.2001.01170.x | PubMed ID:11260326 | HubMed [Paper14]
  15. Pinge-Filho P, Tadokoro CE, and Abrahamsohn IA. Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection. Cell Immunol. 1999 Apr 10;193(1):90-8. DOI:10.1006/cimm.1999.1463 | PubMed ID:10202116 | HubMed [Paper15]
  16. Borges MM, Kloetzel JK, Andrade HF Jr, Tadokoro CE, Pinge-Filho P, and Abrahamsohn I. Prostaglandin and nitric oxide regulate TNF-alpha production during Trypanosoma cruzi infection. Immunol Lett. 1998 Aug;63(1):1-8. DOI:10.1016/s0165-2478(98)00034-0 | PubMed ID:9719432 | HubMed [Paper16]
  17. Tadokoro CE, Macedo MS, and Abrahamsohn IA. Saponin adjuvant primes for a dominant interleukin-10 production to ovalbumin and to Trypanosoma cruzi antigen. Immunology. 1996 Nov;89(3):368-74. DOI:10.1046/j.1365-2567.1996.d01-767.x | PubMed ID:8958049 | HubMed [Paper17]
All Medline abstracts: PubMed | HubMed

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