CONJ606:Materials

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CONJ606.PMCB

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Class Focus, Fall 2017

  1. Organization Meeting and Rules of Engagement
  2. Genomic instability
  3. Data Science
  4. Drug Discovery

Organizational Meeting: Introduction and Scheduling

Evaluation Forms

Week 1: Data Science & Cancer Biology

Papers

Bonus Materials

Lecture Slides

Bad Luck and Cancer: R as a Third Variable

Week 2: Me Myself and I-dentifiers, The Key To Immortality (Persistence)

Papers

Bonus Materials

Lecture Slides


What should we, as life science researchers, pay attention to with identifier use?

Every lesson of the paper will apply to all of us at one point or another, except perhaps for lesson 10. The point is that even though identifier use may be minimal for some individuals, good identifier practice should be observed. Examples of how life scientists use identifiers include citing sources and generating papers and figures. Good identifier practice could be as simple as using DOI to create an identifier for you paper, or could be as complex as using all of the lessons to generate a database that many people can easily use and add to. It depends on what people are doing.

Week 3: TZAP, The Tonsorial Telomere Protein

Papers

Bonus Materials

Lecture Slides

Week 4: Moonshiner drives piRNA transcription

Papers

Bonus Materials

Lecture Slides

Revealing transcription in heterochromatin via PIWI RNA

Week 5

Bonus Materials

“We don’t know which human variations will be advantages and which will be disadvantages in the long arc of our struggle to prevail in an ever-changing environment.”

CTCF Binding Polarity Determines Chromatin Looping*[1]

Gene expression: The coherent Mediator*[2]

Cell division errors: infertility, disorders, and cancers*[3]

Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes*[4]

Cohesin Codes*[5]

Three-Dimensional Genome Organization and Function in Drosophila*[6]

Regulation of disease-associated gene expression in the 3D genome*[7]

Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture*[8]


Lecture Slides

Part 1: *https://ohsu.app.box.com/file/256478474798

Part 2: *https://ohsu.app.box.com/file/247445475386

Week 8: Mitogens and p53 battle for cell cycle control entry

Papers

Bonus Materials

Lecture Slides

The story of inherited molecular “memories” in cells